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Erschienen in:
Orthogonal Protein Translation Using Pyrrolysyl-tRNA Synthetases for Single- and Multiple-Noncanonical Amino Acid Mutagenesis Kapitel lesen Erstes Kapitel lesen

2018 | OriginalPaper | Buchkapitel

Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals

verfasst von : Timothy L. Turner, Heejin Kim, In Iok Kong, Jing-Jing Liu, Guo-Chang Zhang, Yong-Su Jin

Erschienen in: Synthetic Biology – Metabolic Engineering

Verlag: Springer International Publishing

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Abstract

To mitigate global climate change caused partly by the use of fossil fuels, the production of fuels and chemicals from renewable biomass has been attempted. The conversion of various sugars from renewable biomass into biofuels by engineered baker’s yeast (Saccharomyces cerevisiae) is one major direction which has grown dramatically in recent years. As well as shifting away from fossil fuels, the production of commodity chemicals by engineered S. cerevisiae has also increased significantly. The traditional approaches of biochemical and metabolic engineering to develop economic bioconversion processes in laboratory and industrial settings have been accelerated by rapid advancements in the areas of yeast genomics, synthetic biology, and systems biology. Together, these innovations have resulted in rapid and efficient manipulation of S. cerevisiae to expand fermentable substrates and diversify value-added products. Here, we discuss recent and major advances in rational (relying on prior experimentally-derived knowledge) and combinatorial (relying on high-throughput screening and genomics) approaches to engineer S. cerevisiae for producing ethanol, butanol, 2,3-butanediol, fatty acid ethyl esters, isoprenoids, organic acids, rare sugars, antioxidants, and sugar alcohols from glucose, xylose, cellobiose, galactose, acetate, alginate, mannitol, arabinose, and lactose.

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Vorheriges Kapitel Synthetic Biology of Polyhydroxyalkanoates (PHA)
Nächstes Kapitel Corynebacterium glutamicum for Sustainable Bioproduction: From Metabolic Physiology to Systems Metabolic Engineering
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Metadaten
Titel
Engineering and Evolution of Saccharomyces cerevisiae to Produce Biofuels and Chemicals
verfasst von
Timothy L. Turner
Heejin Kim
In Iok Kong
Jing-Jing Liu
Guo-Chang Zhang
Yong-Su Jin
Copyright-Jahr
2018
Buch
Synthetic Biology – Metabolic Engineering

Print ISBN: 978-3-319-55317-7

Electronic ISBN: 978-3-319-55318-4

Copyright-Jahr: 2018

DOI
https://doi.org/10.1007/10_2016_22