Weitere Kapitel dieses Buchs durch Wischen aufrufen
In this chapter, through exploiting recent advances in the integration of sensing system in a digital microfluidics biochip, we present a “physical-aware” system reconfiguration technique that uses sensor data at intermediate checkpoints to reconfigure the biochip dynamically. A cyberphysical re-synthesis technique is used to recompute electrode-actuation sequences, thereby deriving new results for module placement, droplet routing pathways, and operation schedules, with minimum impact on the time-to-response.
Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten
Sie möchten Zugang zu diesem Inhalt erhalten? Dann informieren Sie sich jetzt über unsere Produkte:
K. Chakrabarty and F. Su, Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques, Boca Raton, FL: CRC Press, 2006. CrossRef
T.-W. Huang, C.-H. Lin, and T.-Y. Ho, “A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 29, no. 11, pp. 1682–1695, 2010. CrossRef
E. Maftei, P. Pop, and J. Madsen, “Routing-based synthesis of digital microfluidic biochips”, Proceedings of the 2010 International conference on Compilers, Architectures and Synthesis for Embedded Systems, pp. 41–50, 2010.
T.-W. Huang and T.-Y. Ho, “A two-stage ILP-based droplet routing algorithm for pin-constrained digital microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol 30, no. 2, pp. 215–228, 2011. CrossRef
M. Iyengar and M. McGuire, “Imprecise and qualitative probability in systems biology”, International Conference on Systems Biology, 2007.
O. Levenspiel, Chemical Reaction Engineering, New York: Wiley, 1999.
J. Verheijen and M. Prins, “Reversible electrowetting and trapping of charge: model and experiments”, ACS J. Langmuir, No. 15, pp. 6616–620, 1999.
J. Park, S. Lee, and L. Kanga, “Fast and reliable droplet transport on single-plate electrowetting on dielectrics using nonfloating switching method”, Biomicrofluidics, vol. 4, Issue. 2, pp. 1–8, 2010. CrossRef
E. Welch, Y.-Y. Lin, A. Madison, and R. Fair, “Picoliter DNA sequencing chemistry on an electrowetting-based digital microfluidic platform”, Biotech. J., vol. 6, pp. 165–176, 2011. CrossRef
S. Kotchoni, E. Gachomo, E. Betiku, and O. Shonukan, “A home made kit for plasmid DNA mini-preparation”, African J. Biotech., vol. 2, pp. 88–90, 2003.
Y. Zhao, T. Xu, and K. Chakrabarty, “Integrated control-path design and error recovery in digital microfluidic lab-on-chip”, ACM JETC, vol. 3, no. 11, 2010.
C. Mein, B. Barratt, M. Dunn, T. Siegmund, A. Smith, L. Esposito, S. Nutland, H. Stevens, A. Wilson, M. Phillips, N. Jarvis, S. Law, M. Arruda, and J. Todd, “Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation”, Genome Res., vol. 10, pp. 330–343, 2000. CrossRef
R. Fair, “Digital microfluidics: Is a true lab-on-a-chip possible?”, Microfluidics and Nanofluidics, vol. 3, pp. 245–281, 2007. CrossRef
W. Bialek and J. Onuchic, “Protein dynamics and reaction rates: mode-specific chemistry in large molecules?”, Proceedings of the National Academy of Sciences of the United States of America, vol. 85, pp. 5908–5912, 1988. MathSciNet
N. Jokerst, L. Luan, S. Palit, M. Royal, S. Dhar, M. Brooke, and T. Tyler II, “Progress in chip-scale photonic sensing”, IEEE Trans. Biomedical Circuits and Sys., vol. 3, pp. 202–211, 2009. CrossRef
R. Evans et. al., “Optical detection heterogeneously integrated with a coplanar digital microfluidic lab-on-a-chip platform”, Proc. IEEE Sensors Conf., pp. 423–426, Oct. 2007.
Y. Luo, K. Chakrabarty, and T.-Y. Ho, “A cyberphysical synthesis approach for error recovery in digital microfluidic biochips”, Proc. DATE, pp. 1239–1244, 2012.
Y. Zhao and K. Chakrabarty, “Digital microfluidic logic gates and their application to built-in self-test of lab-on-chip”, IEEE Transactions on Biomedical Circuits and Systems, vol. 4, pp. 250–262, 2010. CrossRef
B. Hadwen, G. Broder, D. Morganti, A. Jacobs, C. Brown, J. Hector, Y. Kubota, and H. Morgan, “Programmable large area digital microfluidic array with integrated droplet sensing for bioassays”, Lab on a Chip, pp. 3305–3313, 2012.
M. Jebrail and A. Wheeler, “Let’s get digital: digitizing chemical biology with microfluidics”, Current Opinion in Chemical Biology, vol. 14, pp. 574–581, 2010. CrossRef
U. Resch-Genger et. al., “Quantum dots versus organic dyes as fluorescent labels”, Nature Methods, pp. 763–775, 2008
R. Sedgewick, Algorithms in C: Graph Algorithms, Boston, MA: Addison-Wesley, Chapter 23, 2001.
S. Kirkpatrick, C. Gelatt and M. Vecchi, “Optimization by simulated annealing”, Science, vol. 220 (4598), pp. 671–680, May 1983.
Y.-L. Hsieh, T.-Y. Ho and K. Chakrabarty, “A reagent-saving mixing algorithm for preparing multiple-target biochemical samples using digital microfluidics”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 31, pp. 1656–1669, 2012. CrossRef
- Error-Recovery in Cyberphysical Biochips
- Chapter 2