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Erschienen in:
2020 | OriginalPaper | Buchkapitel
Estimating the Rate of Cell Type Degeneration from Epigenetic Sequencing of Cell-Free DNA
verfasst von : Christa Caggiano, Barbara Celona, Fleur Garton, Joel Mefford, Brian Black, Catherine Lomen-Hoerth, Andrew Dahl, Noah Zaitlen
Erschienen in: Research in Computational Molecular Biology
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Abstract
Cells die at different rates as a function of disease state, age, environmental exposure, and behavior [8, 10]. Knowing the rate at which cells die is a fundamental scientific question, with direct translational applicability. A quantifiable indication of cell death could facilitate disease diagnosis and prognosis, prioritize patients for admission into clinical trials, and improve evaluations of treatment efficacy and disease progression [1, 4, 14, 16]. Circulating cell-free DNA (cfDNA) in the bloodstream originates from dying cells and is a promising non-invasive biomarker for cell death.