The serotonin transporters are target-sites for commonly used antidepressants. [
I] ADAM is a novel radiotracer that selectively binds the serotonin transporters (SERTs) of the central nervous system. The aim for this study was to evaluate a non-invasive reference tissue model for SERTs quantification using the cerebellum as the indirect input function. The four-parameter model (FPM) was compared with the three-parameter model (TPM) using [
I] ADAM dynamic brain SPECT images. The binding potential values derived from both models were the same, but the ratio of delivery (R
) in TPM had a smaller standard deviation than the FPM model. In conclusion, the simplified reference tissue model (TPM) was the better choice because of its stability (small standard deviation) and convenient implementation for non-invasive quantification of brain SPECT studies.
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