The existence of different types of tachykinin receptors in the central nervous system has been shown in binding studies, as well as by using immunohistochemical or autoradiographic techniques. In the present study the electrophysiological effects of various tachykinins were investigated in the isolated hemisected spinal cord preparation of the neonatal rat. Earlier studies with this preparation had shown that tachykinin antagonists, characterized in peripheral tissues, were neither selective nor potent enough to antagonize responses to tachykinin agonists [1, 2]. We, therefore, investigated the possibility that desensitization experiments could reveal different tachykinin receptors in the mammalian spinal cord. In addition, desensitization experiments were carried out with the same goal in a peripheral organ preparation, the guinea-pig ileum.
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- Evidence for at Least Two Tachykinin Receptor Subtypes in the Mammalian Spinal Cord
B. E. B. Sandberg
- Springer New York
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