Substance P, eledoisin and physalaemin are undecapeptides that share a common C terminus amino acid sequence and therefore belong to the tachykinin family. The rat hippocampus contains scattered substance P immunoreactive fibres , as well as binding sites for radiolabelled physalaemin . The hippocampus also contains numerous bombesin binding sites  and densely staining ranatens in immunoreactive fibres . All these observations suggest that tachykinins and bombesin may act in the hippocampus. However, Dodd and Kelly  reported that rat hippocampal pyramidal neurones were not responsive to substance P, and although some were excited by bombesin, their response was modest and desensitized rapidly. We have thus re-examined the actions of tachykinins and of bombesin in the hippocampus by assessing their effects on non-pyramidal neurones . Amongst these cells are inhibitory interneurones , which respond to neurohypophysial peptides by increased firing [8,9] and to opioid peptides by a decrease in firing rate .
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- Excitatory Effects of Substance P and Related Peptides on Oxytocin-Sensitive Non-Pyramidal Neurones in Rat Hippocampus
J. J. Dreifuss
- Springer New York
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