Most available artificial intelligence models for bubble-point pressure (
Pb) and oil formation volume factor (
Bob) are multiple-input single-output models that are not reproducible or with complex topology. In this study, a multiple-input multiple-output genetically optimized neural network to predict oil
Pb and
Bob was developed using solution gas–oil ratio, API-oil gravity, gas gravity and reservoir temperature from 781 published datasets. The overall performance of the developed neural network resulted in a correlation coefficient (
R) of 0.99918 and a mean square error (MSE) of 5.9941 × 10
–4. The developed
Pb and
Bob models predictions resulted in a coefficient of determination (
R2) of 0.9985 and
R-value of 0.99423 for
Pb, then
R2 of 0.9842 and
R-value of 0.99207 for
Bob. Also, the
Pb model had MSE of 2.0 × 10
–4, root mean square error (RMSE) of 4.45 × 10
–3 and average absolute percent relative error (AAPRE) of 0.4447, while
Bob had 1.0 × 10
–4, 3.9 × 10
–3 and 0.0391 for MSE, RMSE and AAPRE, respectively. Furthermore, the generalization capacity of the developed models with new datasets resulted in
R2,
R, MSE, RMSE and AAPRE of 0.9613, 0.98046, 0.03713, 0.1927 and 19.2698, respectively, for
Pb, as the
Bob model had
R2 of 0.9499,
R of 0.97463, MSE of 0.0218, RMSE of 0.14763 and AAPRE of 8.20211. Again, the developed
Pb and
Bob models' generality performance showed that they outperformed some published correlations: Standing [
1], Glaso [
2], Al-Marhoun [
3], Dokla and Osman [
4], Almehaideb [
5], Al-Shammasi [
6], etc. Thus, these developed explicit
Pb and
Bob models for oil reservoir PVT prediction can be applied.