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Erschienen in: Microsystem Technologies 1/2018

14.02.2017 | Technical Paper

Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles

verfasst von: Md. Abdur Rahman, Bungo Ochiai

Erschienen in: Microsystem Technologies | Ausgabe 1/2018

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Abstract

This paper describes fabrication of a new hemocompatible, magnetic nanoparticles based on magnetite and naturally occurring chitosan, potentially applicable as biomaterials to nanobiomedicine. We fabricated carboxy-functionalized magnetite–chitosan (Fe3O4–CS–BTCDA) nanocomposite particles by a simple two-stage protocol. Magnetite–chitosan (Fe3O4–CS) nanocomposite particles were first prepared via in situ chemical coprecipitation reactions using Fe2+ and Fe3+ salts in an alkaline aqueous solution of CS. Fe3O4–CS nanocomposite particles were then reacted with butanetetracarboxylic dianhydride (BTCDA) to obtain the Fe3O4–CS–BTCDA nanocomposite particles dispersible under physiological conditions. The obtained nanoparticles are superparamagnetic. The hemolytic activity of the Fe3O4–CS–BTCDA nanocomposite particles is very low and essential for practical bio-related applications.

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Metadaten
Titel
Fabrication and hemocompatibility of carboxy-chitosan stabilized magnetite nanoparticles
verfasst von
Md. Abdur Rahman
Bungo Ochiai
Publikationsdatum
14.02.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Microsystem Technologies / Ausgabe 1/2018
Print ISSN: 0946-7076
Elektronische ISSN: 1432-1858
DOI
https://doi.org/10.1007/s00542-017-3318-8

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