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Microsystem Technologies
Erschienen in: Microsystem Technologies 3/2020

08.08.2019 | Technical Paper

Fabrication method with high-density, high-height microneedle using microindentation method for drug delivery system

verfasst von: Yoshihiro Hasegawa, Yuka Yasuda, Kazuhiro Taniguchi, Mitsuhiro Shikida

Erschienen in: Microsystem Technologies | Ausgabe 3/2020

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Abstract

We have developed a microneedle formation method that has high needle height and density by forming indentations on a metal plate using a micro-machined silicon microneedle, called the “microindentation method.” When a silicon microneedle is used as an indenter that is stamped onto a metal plate and the formed indentation has the same shape as the Si microneedle formed by plastic deformation of metal plate, it is possible to fabricate a microneedle mold arranged in an array by repeating indentation formation while changing the position using a single silicon microneedle. In this research, we developed an indentation apparatus that repeatedly forms indentations on lead plates to successfully fabricate a high-density microneedle array that has the height of the silicon microneedle as the indenter.
Vorheriger Artikel Dielectrophoresis-based microfluidic platform to sort micro-particles in continuous flow
Nächster Artikel Comparative study of tuning of microfabrication parameters for improving electrochemical performance of platinum and glassy carbon microelectrodes in neural prosthetics

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Literatur
Amarlall J, Pinto V, Costa T, Gaspar J, Ferreira R, Paz E, Cardoso S, Freitas PP (2013) Integration of TMR sensors in silicon microneedles for magnetic measurements of neurons. IEEE Trans Magn 49(7):3512–3515CrossRef
Bos JD, Meinardi MM (2000) The 500 Dalton rule for the skin penetration of chemical compounds and drugs. J Exp Dermatol 9(3):165–169CrossRef
Chandrasekaran S, Brazzle JD, Frazier AB (2003) Surface micromachined metallic microneedles. J Microelectromech Syst 12(3):281–288CrossRef
Chiaranairungroj M, Pimpin A, Srituravanich W (2018) Fabrication of high-density microneedle masters towards the commercialisation of dissolving microneedles. Micro Nano Lett 13(3):284–288CrossRef
Davis SP, Martanto W, Allen MG, Prausnitz MR (2005) Hollow metal microneedles for insulin delivery to diabetic rats. IEEE Trans Biomed Eng 52(5):909–915CrossRef
Gardeniers HJGE, Luttge R, Berenschot EJW, de Boer MJ, Yeshurun SY, Hefetz M, van’t Oever R, van den Berg A (2003) Silicon micromachined hollow microneedles for transdermal liquid transport. J Microelectromech Syst 12(6):855–862CrossRef
Gehl J (2003) Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol Scand 177(4):437–447CrossRef
Gerste MS, Place VA (1976) Drug delivery device. US Patent 3,964,482
Griss P, Stemme G (2003) Side-opened out-of-plane microneedles for microfluidic transdermal liquid transfer. J Microelectromech Syst 12(3):296–301CrossRef
Hasegawa Y, Yasuda Y, Taniguchi K, Shikida M (2018) Metal plastic forming by mechanical Si structure indentation for producing metal mold master applied for high density needle fabrication. In: Technical digest of Asia-Pacific conference of transducers and micro-nano technology 2018
Henry S, McAllister DV, Allen MG, Prausnitz MR (1998) Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 87(8):922–925CrossRef
Imaeda K, Bessho K, Shikida M (2015) Sharp tip-separable microneedle device for trans-dermal drug delivery systems. In: Technical digest of 2015 transducers—2015 18th international conference on solid-state sensors, actuators and microsystems (TRANSDUCERS)
Kitamura N, Chim J, Miki N (2013) Micro-needle electrode array for electro tactile display. In: Technical digest of 2013 transducers and eurosensors XXVII: the 17th international conference on solid-state sensors, actuators and microsystems
Kwon KY, Khomenko A, Haq M, Li W (2013) Integrated slanted microneedle-LED array for optogenetics. In: Technical digest of 2013 35th annual international conference of the IEEE engineering in medicine and biology society (EMBC)
Lin L, Pisano AP (1999) Silicon-processed microneedles. IEEE J Microelectromech Syst 8(1):78–84CrossRef
Park J-H, Yoon Y-K, Choi S-O, Prausnitz MR, Allen MG (2007) Tapered conical polymer microneedles fabricated using an integrated lens technique for transdermal drug delivery. IEEE Trans Biomed Eng 54(5):903–913CrossRef
Rawat S, Vengurlekar S, Rakesh B, Jain S, Srikarti G (2008) Transdermal delivery by iontophoresis. Indian J Pharm Sci 70(1):5–10CrossRef
Roxhed N, Gasser TC, Griss P, Holzapfel GA, Stemme G (2007) Penetration-enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery. J Microelectromech Syst 16(6):1429–1440CrossRef
Roxhed N, Samel B, Nordquist L, Griss P, Stemme G (2008) Painless drug delivery through microneedle-based transdermal patches featuring active infusion. IEEE Trans Biomed Eng 55(3):1063–1071CrossRef
Sasaki H, Shikida M, Sato K (2007) Fabrication of densely arrayed Si needles with large height for transdermal drug delivery system application. IEEJ Trans Electr Electron Eng 2:340–347CrossRef
Shikida M, Kitamura S, Miyake C, Bessho K (2014) Micromachined pyramidal shaped biodegradable microneedle and its skin penetration capability. Microsyst Technol 20(12):2239–2245CrossRef
Stoeber B, Liepmann D (2005) Arrays of hollow out-of-plane microneedles for drug delivery. J Microelectromech Syst 14(3):472–479CrossRef
Talbi Y, Brulin D, Campo E, Fourniols JY, Martin B, Blanzat M (2016) Transdermal drug delivery system: active method for enhancing and controlling lidocaine hydrochloride diffusion. In: 2016 IEEE EMBS conference on biomedical engineering and sciences (IECBES)
Wang Y, Guo K, Pei W-H, Gui Q, Li X-Q, Chen H-D, Yang J-H (2011) Fabrication of dry electrode for recording bio-potentials. Chin Phys Lett 29(1):010701CrossRef
Yang SY, O’Cearbhaill EO, Sisk GC, Park KM, Cho WK, Villiger M, Bouma BE, Pomahac B, Karp JM (2013) A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue. Nat Commun 4:1702CrossRef
Zhang H, Pei W, Chen Y, Guo X, Wu X, Yang X, Chen H (2015) A motion interference-insensitive flexible dry electrode. IEEE Trans Biomed Eng 63(6):1136–1144CrossRef
Metadaten
Titel
Fabrication method with high-density, high-height microneedle using microindentation method for drug delivery system
verfasst von
Yoshihiro Hasegawa
Yuka Yasuda
Kazuhiro Taniguchi
Mitsuhiro Shikida
Publikationsdatum
08.08.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Microsystem Technologies / Ausgabe 3/2020
Print ISSN: 0946-7076
Elektronische ISSN: 1432-1858
DOI
https://doi.org/10.1007/s00542-019-04571-4

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