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24.05.2021 | Chemical routes to materials

Fe,N-doped carbon as peroxidase mimics for single-use colorimetric bioassays

verfasst von: Lumin Wang, Jialu Xue, Jin Chang, Chenyang Yu, Henghan Dai, Zhenjie Yao, Jinyuan Zhou, Gengzhi Sun, Wei Huang

Erschienen in: Journal of Materials Science | Ausgabe 24/2021

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Abstract

Nanozymes as promising alternatives to natural enzymes have attracted enormous attentions for their high robustness, low cost, and tunable activity. Among various candidates, carbonaceous nanomaterials possess extra advantage features of designable surface properties and good biocompatibility. However, their peroxidase-like activity is typically moderate owing to the short half-life of radical hydroxyl (·OH), the poor catalytic activity and substrate affinity. Herein, we synthesize Fe,N-doped carbon (Fe,N-C-800) via pyrolyzing Fe-doped ZIF-8 (ZnFe-ZIF) in NH₃ at 800 °C. Fe,N-C-800 shows excellent peroxidase mimic with outstanding substrate affinity and catalytic velocity superior to the advanced Fe single-atom catalyst. The excellent enzyme-like performance is ascribed to the synergistic contributions of Fe- and N-doping. Fe functions as catalytic center while pyrrolic N absorbs TMB (3,3’,5,5’-Tetramethylbenzidine) substrate and enhances the electron density of Fe sites, thereby shortening the migration distance of ·OH and further improving the catalytic activity. Based on Fe,N-C-800, disposable paper bioassays are fabricated and exhibit ultrasensitive detection of H₂O₂.

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Vorheriger Artikel Ferromagnetism in two-dimensional black phosphorus induced by phthalocyanine cobalt

Nächster Artikel Structure modulation of periodic mesoporous organosilicas with organic salts

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Sun Y, Xu H, Zhao X, Hui ZY, Yu CY, Wang LM, Xue JL, Zhao Y, Zhou RC, Dai HH, Miao C, Chen Q, Zhou JY, Sun GZ, Huang W (2019) Identifying the active site of ultrathin NiCo LDH as an efficient peroxidase mimic with superior substrate affinity for sensitive detection of hydrogen peroxide. J Mater Chem B 7:6232–6237CrossRef

Sun Y, Xu H, Wang LM, Yu CY, Zhou JY, Chen Q, Sun GZ, Huang W (2021) Ultrathin NiMn layered double hydroxide nanosheets with a superior peroxidase mimicking performance to natural HRP for disposable paper-based bioassays. J Mater Chem B 9:983–991CrossRef

Wu Y, Jiao L, Luo X (2019) Oxidase-like Fe–N–C single-atom nanozymes for the detection of acetylcholinesterase activity. Small 15:1903108CrossRef

Huang L, Chen J, Gan L, Wang J, Dong S (2019) Single-atom nanozymes. Sci Adv 5:eaav5490CrossRef

Hafez ME, Ma H, Ma W, Long YT (2019) Unveiling the intrinsic catalytic activities of single-gold-nanoparticle-based enzyme mimetics. Angew Chem Int Ed 58:6327–6332CrossRef

Han L, Zhang H, Chen D, Li F (2018) Protein-directed metal oxide nanoflakes with tandem enzyme-like characteristics: colorimetric glucose sensing based on one-pot enzyme-free cascade catalysis. Adv Funct Mater 28:1800018CrossRef

Ma W, Mao J, Yang X (2018) A single-atom Fe–N₄ catalytic site mimicking bifunctional antioxidative enzymes for oxidative stress cytoprotection. Chem Commun 55:159–162CrossRef

Cheng N, Li JC, Liu D, Lin Y, Du D (2019) Single-atom nanozyme based on nanoengineered Fe–N–C catalyst with superior peroxidase-like activity for ultrasensitive bioassays. Small 15:1901485CrossRef

Wang Y, Qi K, Yu S (2019) Revealing the intrinsic peroxidase-like catalytic mechanism of heterogeneous single-atom Co-MoS₂. Nano-Micro Lett 11:102–115CrossRef

10.

Yang X, Yang Y, Gao F, Wei JJ, Qian CG, Sun MJ (2019) Biomimetic hybrid nanozymes with self-supplied H⁺ and accelerated O₂ generation for enhanced starvation and photodynamic therapy against hypoxic tumors. Nano Lett 19:4334–4342CrossRef

11.

Huo M, Wang L, Wang Y, Chen Y, Shi J (2019) Nanocatalytic tumor therapy by single-atom catalysts. ACS Nano 13:2643–2653

12.

Yao S, Xu J, Wang Y, Chen X, Xu Y, Hu S (2006) A highly sensitive hydrogen peroxide amperometric sensor based on MnO₂ nanoparticles and dihexadecyl hydrogen phosphate composite film. Anal Chim Acta 557:78–84CrossRef

13.

Niu X, Shi Q, Zhu W (2019) Unprecedented peroxidase-mimicking activity of single-atom nanozyme with atomically dispersed Fe–N_x moieties hosted by MOF derived porous carbon. Biosens Bioelectron 142:111495CrossRef

14.

Lou Z, Zhao S, Wang Q, Wei H (2019) N-doped carbon as peroxidase-like nanozymes for total antioxidant capacity assay. Anal Chem 91:15267–15274CrossRef

15.

Yu CY, Gong YJ, Chen RY, Zhang MY, Zhou JY, An JN, Lv F, Guo SJ, Sun GZ (2018) A Solid-state fibriform supercapacitor boosted by host-guest hybridization between the carbon nanotube scaffold and MXene nanosheets. Small 14:1801203CrossRef

16.

Kim MS, Cho S, Joo SH (2019) N-and B-codoped graphene: a strong candidate to replace natural peroxidase in sensitive and selective bioassays. ACS Nano 13:4312–4321CrossRef

17.

Wu G, Santandreu A, Kellogg W, Gupta S, Ogoke O, Zhang H (2016) Carbon nanocomposite catalysts for oxygen reduction and evolution reactions: from nitrogen doping to transition-metal addition. Nano Energy 29:83–110CrossRef

18.

Wang B, Zhao J, Yue Y (2019) Carbon with surface-enriched nitrogen and sulfur supported Au catalysts for acetylene hydrochlorination. ChemCatChem 11:1002–1009

19.

Wang T, Yang R, Shi N et al (2019) Cu, N-codoped carbon nanodisks with biomimic stomata-like interconnected hierarchical porous topology as efficient electrocatalyst for oxygen reduction reaction. Small 15:1902410CrossRef

20.

Mun Y, Lee S, Kim K (2019) Versatile strategy for tuning ORR activity of a single Fe–N₄ site by controlling electron-withdrawing/donating properties of a carbon plane. J Am Chem Soc 141:6254–6262CrossRef

21.

Gong YJ, RYChen, H Xu, CY Yu, X Zhao, Y Sun, ZY Hui, JY Zhou, JN An, ZZ Du, GZ Sun, W Huang, (2019) Polarity-assisted formation of hollow-frame sheathed nitrogen-doped nanofibrous carbon for supercapacitors. Nanoscale 11:2492–2500CrossRef

22.

Du ZZ, Ai W, Yang J, Gong YJ, Yu CY, Zhao JF, Dong XC, Sun GZ, Huang W (2018) In situ fabrication of Ni₂P nanoparticles embedded in nitrogen and phosphorus codoped carbon nanofibers as a superior anode for Li-ion batteries. ACS Sustainable Chem Eng 6:14795–14801CrossRef

23.

Du ZZ, Ai W, Yu CY, Gong YJ, Chen RY, Sun GZ, Huang W (2019) A facile grinding approach to embed red phosphorus in N, P-codoped hierarchical porous carbon for superior lithium storage. Sci China Mater 63:55–61CrossRef

24.

Fan K, Xi J, Fan L (2018) In vivo guiding nitrogen-doped carbon nanozyme for tumor catalytic therapy. Nat Commun 9:1440–1451CrossRef

25.

Zhang C, Fu L, Liu N, Liu M, Wang Y, Liu Z (2011) Synthesis of nitrogen-doped graphene using embedded carbon and nitrogen sources. Adv Mater 23:1020–1024CrossRef

26.

Hu Y, Gao XJ, Zhu Y (2018) Nitrogen-doped carbon nanomaterials as highly active and specific peroxidase mimics. Chem Mater 30:6431–6439CrossRef

27.

Wu G, Mack NH, Gao W (2012) Nitrogen-doped graphene-rich catalysts derived from heteroatom polymers for oxygen reduction in nonaqueous lithium–O₂ battery cathodes. ACS Nano 6:9764–9776CrossRef

28.

Li Q, Xu P, Gao W (2014) Graphene/graphene-tube nanocomposites templated from cage-containing metal-organic frameworks for oxygen reduction in Li–O₂ batteries. Adv Mater 26:1378–1386CrossRef

29.

Wu G, Nelson M, Ma S, Meng H, Cui G, Shen PK (2011) Synthesis of nitrogen-doped onion-like carbon and its use in carbon-based CoFe binary non-precious-metal catalysts for oxygen-reduction. Carbon 49:3972–3982CrossRef

30.

Zhao X, Xu H, Hui ZY, Sun Y, Yu CY, Xue JL, Zhou RC, Wang LM, Dai HH, Zhao Y, Yang J, Zhou JY, Chen Q, Sun GZ, Huang W (2019) Electrostatically assembling 2D nanosheets of MXene and MOF-derivatives into 3D hollow frameworks for enhanced lithium storage. Small 15:1904255CrossRef

31.

Wang J, Huang Z, Liu W, Chang C, Tang H, Li Z (2017) Design of N-coordinated dual-metal sites: a stable and active Pt-free catalyst for acidic oxygen reduction reaction. J Am Chem Soc 139:17281–17284CrossRef

32.

Ma L, Jiang F, Fan X, Wang L, He C, Zhou M (2020) Metal-organic-framework-engineered enzyme-mimetic catalysts. Adv Mater 32:2003065CrossRef

33.

Fu S, Zhu C, Su D (2018) Porous carbon-hosted atomically dispersed iron-nitrogen moiety as enhanced electrocatalysts for oxygen reduction reaction in a wide range of pH. Small 14:1703118CrossRef

34.

Zheng Y, Qiao SZ (2018) Metal-organic framework assisted synthesis of single-atom catalysts for energy applications. Nat Sci Rev 5:626–627CrossRef

35.

Xu Y, Xue J, Zhou Q (2020) The Fe-N-C nanozyme with both accelerated and inhibited bio-catalytic activities capable of accessing drug–drug interactions. Angew Chem Int Ed 59:2–8

36.

Yang L, Cheng D, Xu H (2018) Unveiling the high-activity origin of single-atom iron catalysts for oxygen reduction reaction. Proc Natl Acad Sci USA 115:6626–6631CrossRef

37.

Peng Y, Lu B, Chen S (2018) Carbon-supported single atom catalysts for electrochemical energy conversion and storage. Adv Mater 30:1801995CrossRef

38.

Wang H, Yin FX, Liu N (2019) Engineering Fe–Fe₃C@Fe–N–C active sites and hybrid structures from dual metal-organic frameworks for oxygen reduction reaction in H₂–O₂ fuel cell and Li–O₂ battery. Adv Funct Mater 29:1801995

39.

Tian M, Zhu Y, Zhang D (2019) Pyrrolic-nitrogen-rich biomass-derived catalyst for sustainable degradation of organic pollutant via a self-powered electro-fenton process. Nano Energy 64:103940CrossRef

40.

Cheng H, Lin S, Muhammad F, Lin YW, Wei H (2016) Rationally modulate the oxidase-like activity of nanoceria for self-regulated bioassays. ACS Sens 1:1336–1343CrossRef

41.

Zhu X, Chen W, Wu K (2018) A colorimetric sensor of H₂O₂ based on Co₃O₄-montmorillonite nanocomposites with peroxidase activity. New J Chem 42:1501–1509CrossRef

42.

Xi J, Wei G, Wu Q (2019) Light-enhanced sponge-like carbon nanozyme used for synergetic antibacterial therapy. Biomater Sci 7:4131–4141CrossRef

43.

Kim MS, Lee J, Kim HS (2020) Heme cofactor-resembling Fe-N single site embedded graphene as nanozymes to selectively detect H₂O₂ with high sensitivity. Adv Funct Mater 30:1905410CrossRef

44.

Jampaiah D, Srinivasa Reddy T, Kandjani AE, Selvakannan PR, Sabri YM, Coyle VE et al (2016) Fe-doped CeO2 nanorods for enhanced peroxidase-like activity and their application towards glucose detection. J Mater Chem B 4:3874–3885CrossRef

45.

Zhou X, Wang M, Chen J, Xie X, Su X (2020) Peroxidase-like activity of Fe–N–C single-atom nanozyme based colorimetric detection of galactose. Anal Chim Acta 1128:72–79CrossRef

46.

Ai L, Li L, Zhang C, Fu J, Jiang J (2013) MIL-53(Fe): a metal-organic framework with intrinsic peroxidase-like catalytic activity for colorimetric biosensing. Chem A Eur J 19:15105–15108 CrossRef

47.

Jiao L, Xu W, Yan H (2019) Fe–N–C single-atom nanozymes for the intracellular hydrogen peroxide detection. Anal Chem 91:11994–11999CrossRef

48.

Chen Q, Li S, Liu Y (2020) Size-controllable Fe–N/C single-atom nanozyme with exceptional oxidase-like activity for sensitive detection of alkaline phosphatase. Sens Actuators B 305:127511CrossRef

49.

Zhao C, Xiong C, Liu X (2019) Unraveling the enzyme-like activity of heterogeneous single atom catalyst. Chem Commun 55:2285–2288CrossRef

50.

Li Z, Liang X, Gao Q (2019) Fe, N co-doped carbonaceous hollow spheres with self-grown carbon nanotubes as a high performance binary electrocatalyst. Carbon 154:466–477CrossRef

51.

Nandan R, Gautam A, Nanda KK (2017) Maximizing the utilization of Fe–N_xC/CN_x centres for an air-cathode material and practical demonstration of metal–air batteries. J Mater Chem A 5:20252–20262CrossRef

52.

Li X, Huang X, Xi S (2018) Single cobalt atoms anchored on porous N-doped graphene with dual reaction sites for efficient fenton-like catalysis. J Am Chem Soc 140:12469–12475CrossRef

53.

Wang Q, Ina T, Chen WT, Shang L, Sun FF, Wei SH, Sun-Waterhouse DX, Telfer SG, Zhang T, Waterhouse GIN (2020) Evolution of Zn(II) single atom catalyst sites during the pyrolysis-induced transformation of ZIF-8 to N-doped carbons. Sci Bulletin 65:1743–1751CrossRef

54.

Zhang W, Niu X, Li X (2018) A smartphone-integrated ready-to-use paper-based sensor with mesoporous carbon-dispersed Pd nanoparticles as a highly active peroxidase mimic for H₂O₂ detection. Sens Actuators B 265:412–420CrossRef

55.

Lu Y, Ye W, Yang Q (2016) Three-dimensional hierarchical porous PtCu dendrites: a highly efficient peroxidase nanozyme for colorimetric detection of H₂O₂. Sens Actuators B 230:721–730CrossRef

Titel: Fe,N-doped carbon as peroxidase mimics for single-use colorimetric bioassays
verfasst von: Lumin Wang
Jialu Xue
Jin Chang
Chenyang Yu
Henghan Dai
Zhenjie Yao
Jinyuan Zhou
Gengzhi Sun
Wei Huang
Publikationsdatum: 24.05.2021
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 24/2021
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-021-06190-9

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