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Erschienen in:
2005 | OriginalPaper | Buchkapitel
Fixed-Parameter Algorithms for Protein Similarity Search Under mRNA Structure Constraints
verfasst von : Guillaume Blin, Guillaume Fertin, Danny Hermelin, Stéphane Vialette
Erschienen in: Graph-Theoretic Concepts in Computer Science
Verlag: Springer Berlin Heidelberg
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In the context of protein engineering, we consider the problem of computing an mRNA sequence of maximal codon-wise similarity to a given mRNA (and consequently, to a given protein) that additionally satisfies some secondary structure constraints, the so-called MRSO problem [2]. Since the MRSO problem is known to be
APX
-hard [8], Bongartz proposed in [8] to attack the problem using the concept of parameterized complexity. In this paper we follow this suggested approach by devising fixed-parameter algorithms for several interesting parameters of MRSO. We believe these algorithms to be relevant for practical applications today, as well as for several future applications. Furthermore, our results extend the known tractability borderline of MRSO, and provide new research horizons for further improvements of this sort.