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Arabian Journal for Science and Engineering
Erschienen in: Arabian Journal for Science and Engineering 6/2020

09.04.2020 | Research Article-Biological Sciences

Flavonoid Treatment of Breast Cancer Cells has Multifarious Consequences on Alpha-1-Syntrophin Expression and other Downstream Processes

verfasst von: Sahar Saleem Bhat, Umar Mushtaq, Roshia Ali, Firdous Ahmad Khanday

Erschienen in: Arabian Journal for Science and Engineering | Ausgabe 6/2020

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Abstract

Alpha-1-syntrophin (SNTA1) is emerging as an important regulator of cell signaling. SNTA1 forms a part of the dystrophin glycoprotein complex (DGC) and takes part in signaling pathways via the DGC. SNTA1 has been seen to be over expressed in various carcinomas, including breast, esophageal and colon cancer. In this study, we analyze the effect of anti-cancer compounds vis-à-vis quercetin and kaempferol on the expression of SNTA1 protein, reactive oxygen species (ROS) production and cell migration in breast cancer cells. Quercetin as well kaempferol treatment leads to a decrease in the expression of SNTA1 protein in HBL100 cells as well as a decrease in both ROS production and cell migration. The multipartite effects of the flavonoids in HBL100 cells can pave the way for further studies where SNTA1 is targeted for drug therapy in cancer.
Vorheriger Artikel Antibacterial Activity of Lactobacillus plantarum CRL 759 Against Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa
Nächster Artikel Inference of Magnetized Water Impact on Salt-Stressed Wheat

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Metadaten
Titel
Flavonoid Treatment of Breast Cancer Cells has Multifarious Consequences on Alpha-1-Syntrophin Expression and other Downstream Processes
verfasst von
Sahar Saleem Bhat
Umar Mushtaq
Roshia Ali
Firdous Ahmad Khanday
Publikationsdatum
09.04.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
Arabian Journal for Science and Engineering / Ausgabe 6/2020
Print ISSN: 2193-567X
Elektronische ISSN: 2191-4281
DOI
https://doi.org/10.1007/s13369-020-04508-4

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