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2019 | OriginalPaper | Buchkapitel

10. From the Outside In: Integrating External Exposures into the Exposome Concept

verfasst von : Yuxia Cui, David Balshaw

Erschienen in: Unraveling the Exposome

Verlag: Springer International Publishing

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Abstract

The exposome comprises exposures arising from both endogenous processes and the external environment, which include not only chemical compounds but also nutrients, drugs, infectious agents, the microbiome, physical stress, and psychosocial stress. But where do those exposures come from, and what can we do about them? This chapter will focus on two distinct but interrelated questions: (1) Why understanding the environment outside of the body is critical for unraveling the exposome; and (2) How to measure the exposome from the outside the body. The external environment is critical to unraveling the exposome for it provides a depth of context that analysis of biological samples cannot, it also informs data interpretation by providing linkage between external sources of exposure and the internal dose, and in some cases, external assessment is the only way to objectively evaluate an exposure such as social and built environment as well as behavioral factors. The grand challenge lies in how to provide a comprehensive and rigorous characterization of the external environment on the exposome scale. This chapter will discuss

Scientific advances, emerging technologies, and novel opportunities to unravel the exposome from the external environment
The importance of multi-scale data integration in assessing the temporal and spatial dynamics of the exposome
Strategies and the value of integrating external and internal environments in studies of the exposome
The opportunity of applying the exposome to inform citizen science and disease prevention

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Titel: From the Outside In: Integrating External Exposures into the Exposome Concept
verfasst von: Yuxia Cui
David Balshaw
Verlag: Springer International Publishing
Buch: Unraveling the Exposome
Print ISBN: 978-3-319-89320-4

Electronic ISBN: 978-3-319-89321-1

Copyright-Jahr: 2019
DOI: https://doi.org/10.1007/978-3-319-89321-1_10

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