scheduling architecture for manufacturing systems and their realization in MATLAB are presented. The distributed architecture uses a set of lower level fuzzy control modules that reduce Work-In- Process (WIP) and synchronize the production system’s operation. The production rate in each stage is controlled so as to satisfy demand, avoid overloading and eliminate machine starvation or blocking. Performance tuning of the distributed controllers has been assigned to a supervisory control architecture. The scheduling objective is to keep the WIP as low as possible maintaining, at the same time, quality of service by keeping backlog into acceptable levels. It is also shown, in this chapter, how MATLAB’s SIMULINK may be used to construct effective production systems simulators. SIMULINK has become very popular in academia and industry and provides a number of powerfull tools, that is almost impossible to find in a dedicated tool for discrete event systems simulation.