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2014 | Buch

Bone and Cartilage Tissue Engineering Kapitel lesen Erstes Kapitel lesen

Gene Therapy for Cartilage and Bone Tissue Engineering

verfasst von: Yu-Chen Hu

Verlag: Springer Berlin Heidelberg

Buchreihe : SpringerBriefs in Bioengineering

Enthalten in: Springer Professional "Wirtschaft+Technik" , Springer Professional "Technik"

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SUCHEN

Über dieses Buch

"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.

Inhaltsverzeichnis

Frontmatter
Chapter 1. Bone and Cartilage Tissue Engineering
Abstract
Bone and cartilage are important components in the skeleton system, providing the major structure of the body of vertebrates and conferring protection and support of soft tissues. This chapter briefly reviews the constituents of bones and articular cartilages as well as cells associated with bone/cartilage healing. This chapter further introduces the concepts and critical elements of tissue engineering for the repair/regeneration of bone and cartilage.
Yu-Chen Hu
Chapter 2. Viral Gene Therapy Vectors
Abstract
The vectors for gene delivery can be divided into two classes: viral and nonviral. Despite the rapid progress in the development of nonviral gene delivery, viral vectors such as retrovirus/lentivirus, adenovirus, adeno-associated virus (AAV) and baculovirus mediate more efficient delivery than nonviral vectors, especially for primary cells. This chapter briefly compares the nonviral and viral vectors and mainly discusses the development and characteristics of these viral vectors.
Yu-Chen Hu
Chapter 3. Gene Therapy for Bone Tissue Engineering
Abstract
Gene therapy has been employed in conjunction with bone engineering over the past decade, by which a variety of therapeutic genes are delivered to stimulate bone repair. These genes can be administered via in vivo or ex vivo approaches using either viral or nonviral vectors. This chapter reviews the fundamental aspects and recent progresses in the gene therapy-based bone engineering, with emphasis on the new genes, vectors and gene delivery approaches.
Yu-Chen Hu
Chapter 4. Gene Therapy for Cartilage Tissue Engineering
Abstract
Gene therapy has converged with cartilage engineering in recent years, by which an increasing number of therapeutic genes have been explored to stimulate cartilage repair. These genes can be administered to cells via in vivo or ex vivo approaches using either viral or nonviral vectors. This chapter reviews various growth factors and delivery approaches under investigation.
Yu-Chen Hu
Chapter 5. Conclusions and Perspectives
Abstract
Gene therapy has been widely explored for the treatment of various diseases and disorders, yet successful applications of gene therapy in bone and cartilage engineering are still not in the near horizon. This chapter summarizes the major hurdles that set the roadblocks to the application of gene therapy in tissue engineering and discusses future perspectives.
Yu-Chen Hu
Metadaten
Titel
Gene Therapy for Cartilage and Bone Tissue Engineering
verfasst von
Yu-Chen Hu
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
Electronic ISBN
978-3-642-53923-7
Print ISBN
978-3-642-53922-0
DOI
https://doi.org/10.1007/978-3-642-53923-7

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