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2014 | OriginalPaper | Buchkapitel

4. Gene Therapy for Cartilage Tissue Engineering

verfasst von : Yu-Chen Hu

Erschienen in: Gene Therapy for Cartilage and Bone Tissue Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

Gene therapy has converged with cartilage engineering in recent years, by which an increasing number of therapeutic genes have been explored to stimulate cartilage repair. These genes can be administered to cells via in vivo or ex vivo approaches using either viral or nonviral vectors. This chapter reviews various growth factors and delivery approaches under investigation.

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Literatur
1.
Zurück zum Zitat Wei Y, Hu Y, Lv R, Li D (2006) Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2. Cytotherapy 8:570–579 Wei Y, Hu Y, Lv R, Li D (2006) Regulation of adipose-derived adult stem cells differentiating into chondrocytes with the use of rhBMP-2. Cytotherapy 8:570–579
2.
Zurück zum Zitat Miljkovic N, Cooper G, Marra K (2008) Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage 16:1121–1130 Miljkovic N, Cooper G, Marra K (2008) Chondrogenesis, bone morphogenetic protein-4 and mesenchymal stem cells. Osteoarthritis Cartilage 16:1121–1130
3.
Zurück zum Zitat Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T et al (2006) Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 54:433–442 Kuroda R, Usas A, Kubo S, Corsi K, Peng H, Rose T et al (2006) Cartilage repair using bone morphogenetic protein 4 and muscle-derived stem cells. Arthritis Rheum 54:433–442
4.
Zurück zum Zitat Kemmis CM, Vahdati A, Weiss HE, Wagner DR (2010) Bone morphogenetic protein 6 drives both osteogenesis and chondrogenesis in murine adipose-derived mesenchymal cells depending on culture conditions. Biochem Biophys Res Commun 401:20–25 Kemmis CM, Vahdati A, Weiss HE, Wagner DR (2010) Bone morphogenetic protein 6 drives both osteogenesis and chondrogenesis in murine adipose-derived mesenchymal cells depending on culture conditions. Biochem Biophys Res Commun 401:20–25
5.
Zurück zum Zitat Vukicevic S, Grgurevic L (2009) BMP-6 and mesenchymal stem cell differentiation. Cytokine Growth Factor Rev 20:441–448 Vukicevic S, Grgurevic L (2009) BMP-6 and mesenchymal stem cell differentiation. Cytokine Growth Factor Rev 20:441–448
6.
Zurück zum Zitat Pagnotto MR, Wang Z, Karpie JC, Ferretti M, Xiao X, Chu CR (2007) Adeno-associated viral gene transfer of transforming growth factor-β1 to human mesenchymal stem cells improves cartilage repair. Gene Ther 14:804–813 Pagnotto MR, Wang Z, Karpie JC, Ferretti M, Xiao X, Chu CR (2007) Adeno-associated viral gene transfer of transforming growth factor-β1 to human mesenchymal stem cells improves cartilage repair. Gene Ther 14:804–813
7.
Zurück zum Zitat Han Y, Wei Y, Wang S, Song Y (2010) Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres. Joint Bone Spine 77:27–31 Han Y, Wei Y, Wang S, Song Y (2010) Cartilage regeneration using adipose-derived stem cells and the controlled-released hybrid microspheres. Joint Bone Spine 77:27–31
8.
Zurück zum Zitat Jin X, Sun Y, Zhang K, Wang J, Shi T, Ju X et al (2007) Ectopic neocartilage formation from predifferentiated human adipose derived stem cells induced by adenoviral-mediated transfer of hTGF beta2. Biomaterials 28:2994–3003 Jin X, Sun Y, Zhang K, Wang J, Shi T, Ju X et al (2007) Ectopic neocartilage formation from predifferentiated human adipose derived stem cells induced by adenoviral-mediated transfer of hTGF beta2. Biomaterials 28:2994–3003
9.
Zurück zum Zitat Bouffi C, Thomas O, Bony C, Giteau A, Venier-Julienne M-C, Jorgensen C et al (2010) The role of pharmacologically active microcarriers releasing TGF-β3 in cartilage formation in vivo by mesenchymal stem cells. Biomaterials 31:6485–6493 Bouffi C, Thomas O, Bony C, Giteau A, Venier-Julienne M-C, Jorgensen C et al (2010) The role of pharmacologically active microcarriers releasing TGF-β3 in cartilage formation in vivo by mesenchymal stem cells. Biomaterials 31:6485–6493
10.
Zurück zum Zitat Hennig T, Lorenz H, Thiel A, Goetzke K, Dickhut A, Geiger F et al (2007) Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 211:682–691 Hennig T, Lorenz H, Thiel A, Goetzke K, Dickhut A, Geiger F et al (2007) Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6. J Cell Physiol 211:682–691
11.
Zurück zum Zitat Feng G, Wan Y, Balian G, Laurencin CT, Li X (2008) Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. Growth Factors 26:132–142 Feng G, Wan Y, Balian G, Laurencin CT, Li X (2008) Adenovirus-mediated expression of growth and differentiation factor-5 promotes chondrogenesis of adipose stem cells. Growth Factors 26:132–142
12.
Zurück zum Zitat Fan H, Tao H, Wu Y, Hu Y, Yan Y, Luo Z (2010) TGF-beta3 immobilized PLGA-gelatin/chondroitin sulfate/hyaluronic acid hybrid scaffold for cartilage regeneration. J Biomed Mater Res A 95:982–992 Fan H, Tao H, Wu Y, Hu Y, Yan Y, Luo Z (2010) TGF-beta3 immobilized PLGA-gelatin/chondroitin sulfate/hyaluronic acid hybrid scaffold for cartilage regeneration. J Biomed Mater Res A 95:982–992
13.
Zurück zum Zitat Barry F, Boynton RE, Liu B, Murphy JM (2001) Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res 268:189–200 Barry F, Boynton RE, Liu B, Murphy JM (2001) Chondrogenic differentiation of mesenchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components. Exp Cell Res 268:189–200
14.
Zurück zum Zitat Estes BT, Wu AW, Guilak F (2006) Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum 54:1222–1232 Estes BT, Wu AW, Guilak F (2006) Potent induction of chondrocytic differentiation of human adipose-derived adult stem cells by bone morphogenetic protein 6. Arthritis Rheum 54:1222–1232
15.
Zurück zum Zitat Moioli EK, Hong L, Mao JJ (2007) Inhibition of osteogenic differentiation of human mesenchymal stem cells. Wound Repair Regen 15:413–421 Moioli EK, Hong L, Mao JJ (2007) Inhibition of osteogenic differentiation of human mesenchymal stem cells. Wound Repair Regen 15:413–421
16.
Zurück zum Zitat Tang QO, Shakib K, Heliotis M, Tsiridis E, Mantalaris A, Ripamonti U (2009) TGF-beta3: a potential biological therapy for enhancing chondrogenesis. Expert Opin Biol Ther 9:689–701 Tang QO, Shakib K, Heliotis M, Tsiridis E, Mantalaris A, Ripamonti U (2009) TGF-beta3: a potential biological therapy for enhancing chondrogenesis. Expert Opin Biol Ther 9:689–701
17.
Zurück zum Zitat Mehlhorn AT, Niemeyer P, Kaschte K, Muller L, Finkenzeller G, Hartl D et al (2007) Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells. Cell Prolif 40:809–823 Mehlhorn AT, Niemeyer P, Kaschte K, Muller L, Finkenzeller G, Hartl D et al (2007) Differential effects of BMP-2 and TGF-beta1 on chondrogenic differentiation of adipose derived stem cells. Cell Prolif 40:809–823
18.
Zurück zum Zitat Shen B, Wei A, Tao H, Diwan AD, Ma DD (2009) BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture. Tissue Eng Part A 15:1311–1320 Shen B, Wei A, Tao H, Diwan AD, Ma DD (2009) BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture. Tissue Eng Part A 15:1311–1320
19.
Zurück zum Zitat Lim SM, Oh SH, Lee HH, Yuk SH, Im GI, Lee JH (2010) Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering. J Mater Sci Mater Med 21:2593–2600 Lim SM, Oh SH, Lee HH, Yuk SH, Im GI, Lee JH (2010) Dual growth factor-releasing nanoparticle/hydrogel system for cartilage tissue engineering. J Mater Sci Mater Med 21:2593–2600
20.
Zurück zum Zitat Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H et al (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc Natl Acad Sci U S A 107:10202–10207 Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H et al (2010) Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc Natl Acad Sci U S A 107:10202–10207
21.
Zurück zum Zitat Puetzer JL, Petitte JN, Loboa EG (2010) Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue. Tissue Eng Part B Rev 16:435–444 Puetzer JL, Petitte JN, Loboa EG (2010) Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue. Tissue Eng Part B Rev 16:435–444
22.
Zurück zum Zitat Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD et al (2005) Gene-mediated restoration of cartilage matrix by combination insulin-like factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 12:177–186 Nixon AJ, Haupt JL, Frisbie DD, Morisset SS, McIlwraith CW, Robbins PD et al (2005) Gene-mediated restoration of cartilage matrix by combination insulin-like factor-I/interleukin-1 receptor antagonist therapy. Gene Ther 12:177–186
23.
Zurück zum Zitat Aghaloo T, Cowan CM, Chou YF, Zhang X, Lee H, Miao S et al (2006) Nell-1-induced bone regeneration in calvarial defects. Am J Pathol 169:903–915 Aghaloo T, Cowan CM, Chou YF, Zhang X, Lee H, Miao S et al (2006) Nell-1-induced bone regeneration in calvarial defects. Am J Pathol 169:903–915
24.
Zurück zum Zitat Lee M, Siu RK, Ting K, Wu BM (2010) Effect of Nell-1 delivery on chondrocyte proliferation and cartilaginous extracellular matrix deposition. Tissue Eng Part A 16:1791–1800 Lee M, Siu RK, Ting K, Wu BM (2010) Effect of Nell-1 delivery on chondrocyte proliferation and cartilaginous extracellular matrix deposition. Tissue Eng Part A 16:1791–1800
25.
Zurück zum Zitat Bi WM, Deng JM, Zhang ZP, Behringer RR, de Crombrugghe B (1999) Sox9 is required for cartilage formation. Nat Genet 22:85–89 Bi WM, Deng JM, Zhang ZP, Behringer RR, de Crombrugghe B (1999) Sox9 is required for cartilage formation. Nat Genet 22:85–89
26.
Zurück zum Zitat Cao L, Yang F, Liu G, Yu D, Li H, Fan Q et al (2011) The promotion of cartilage defect repair using adenovirus mediated Sox9 gene transfer of rabbit bone marrow mesenchymal stem cells. Biomaterials 32:3910–3920 Cao L, Yang F, Liu G, Yu D, Li H, Fan Q et al (2011) The promotion of cartilage defect repair using adenovirus mediated Sox9 gene transfer of rabbit bone marrow mesenchymal stem cells. Biomaterials 32:3910–3920
27.
Zurück zum Zitat Lee J-M, Im G-I (2012) SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials 33:2016–2024 Lee J-M, Im G-I (2012) SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials 33:2016–2024
28.
Zurück zum Zitat Ghivizzani SC, Lechman ER, Tio C, Mule KM, Chada S, McCormack JE et al (1997) Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther 4:977–982 Ghivizzani SC, Lechman ER, Tio C, Mule KM, Chada S, McCormack JE et al (1997) Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther 4:977–982
29.
Zurück zum Zitat Ulrich-Vinther M, Duch MR, Soballe K, O’Keefe RJ, Schwarz EM, Pedersen FS (2004) In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J Orthop Res 22:726–734 Ulrich-Vinther M, Duch MR, Soballe K, O’Keefe RJ, Schwarz EM, Pedersen FS (2004) In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. J Orthop Res 22:726–734
30.
Zurück zum Zitat Lechman ER, Jaffurs D, Ghivizzani SC, Gambotto A, Kovesdi I, Mi ZB et al (1999) Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 163:2202–2208 Lechman ER, Jaffurs D, Ghivizzani SC, Gambotto A, Kovesdi I, Mi ZB et al (1999) Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 163:2202–2208
31.
Zurück zum Zitat Oligino T, Ghivizzani SC, Wolfe D, Lechman ER, Krisky D, Mi Z et al (1999) Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther 6:1713–1720 Oligino T, Ghivizzani SC, Wolfe D, Lechman ER, Krisky D, Mi Z et al (1999) Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther 6:1713–1720
32.
Zurück zum Zitat Pan RY, Chen SL, Xiao X, Liu DW, Peng HJ, Tsao YP (2000) Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum 43:289–297 Pan RY, Chen SL, Xiao X, Liu DW, Peng HJ, Tsao YP (2000) Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis Rheum 43:289–297
33.
Zurück zum Zitat Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD et al (2002) In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 5:397–404 Gouze E, Pawliuk R, Pilapil C, Gouze JN, Fleet C, Palmer GD et al (2002) In vivo gene delivery to synovium by lentiviral vectors. Mol Ther 5:397–404
34.
Zurück zum Zitat Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 9:12–20 Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH, McIlwraith CW (2002) Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 9:12–20
35.
Zurück zum Zitat Mease PJ, Wei N, Fudman EJ, Kivitz AJ, Schechtman J, Trapp RG et al (2010) Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 study. J Rheumatol 37:692–703 Mease PJ, Wei N, Fudman EJ, Kivitz AJ, Schechtman J, Trapp RG et al (2010) Safety, tolerability, and clinical outcomes after intraarticular injection of a recombinant adeno-associated vector containing a tumor necrosis factor antagonist gene: results of a phase 1/2 study. J Rheumatol 37:692–703
36.
Zurück zum Zitat Mease P, Wei N, Fudman E, Kivitz A, Schechtman J, Trapp R et al (2008) Safety and clinical outcomes after intra-articular administration of a recombinant adeno-associated vector containing a TNF antagonist gene. Arthritis Rheum 58:S433–S434 Mease P, Wei N, Fudman E, Kivitz A, Schechtman J, Trapp R et al (2008) Safety and clinical outcomes after intra-articular administration of a recombinant adeno-associated vector containing a TNF antagonist gene. Arthritis Rheum 58:S433–S434
37.
Zurück zum Zitat Mi ZB, Ghivizzani SC, Lechman ER, Jaffurs D, Glorioso JC, Evans CH et al (2000) Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum 43:2563–2570 Mi ZB, Ghivizzani SC, Lechman ER, Jaffurs D, Glorioso JC, Evans CH et al (2000) Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints. Arthritis Rheum 43:2563–2570
38.
Zurück zum Zitat Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD (2003) Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 5:R132–R139 Mi Z, Ghivizzani SC, Lechman E, Glorioso JC, Evans CH, Robbins PD (2003) Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 5:R132–R139
39.
Zurück zum Zitat Watanabe S, Imagawa T, Boivin GP, Gao GP, Wilson JM, Hirsch R (2000) Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol Ther 2:147–152 Watanabe S, Imagawa T, Boivin GP, Gao GP, Wilson JM, Hirsch R (2000) Adeno-associated virus mediates long-term gene transfer and delivery of chondroprotective IL-4 to murine synovium. Mol Ther 2:147–152
40.
Zurück zum Zitat Cucchiarini M, Madry H, Ma C, Thurn T, Zurakowski D, Menger MD et al (2005) Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12:229–238 Cucchiarini M, Madry H, Ma C, Thurn T, Zurakowski D, Menger MD et al (2005) Improved tissue repair in articular cartilage defects in vivo by rAAV-mediated overexpression of human fibroblast growth factor 2. Mol Ther 12:229–238
41.
Zurück zum Zitat Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H (2007) Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum 56:158–167 Cucchiarini M, Thurn T, Weimer A, Kohn D, Terwilliger EF, Madry H (2007) Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9. Arthritis Rheum 56:158–167
42.
Zurück zum Zitat Cucchiarini M, Orth P, Madry H (2013) Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo. J Mol Med 91:625–636 Cucchiarini M, Orth P, Madry H (2013) Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo. J Mol Med 91:625–636
43.
Zurück zum Zitat Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD et al (2003) Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 7:460–466 Gouze E, Pawliuk R, Gouze JN, Pilapil C, Fleet C, Palmer GD et al (2003) Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther 7:460–466
44.
Zurück zum Zitat Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleischmann RM, Weaver AL et al (1997) Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337:141–147 Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleischmann RM, Weaver AL et al (1997) Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337:141–147
45.
Zurück zum Zitat Moreland LW (1998) Soluble tumor necrosis factor receptor (p75) fusion protein (ENBREL) as a therapy for rheumatoid arthritis. Rheum Dis Clin North Am 24:579–591 Moreland LW (1998) Soluble tumor necrosis factor receptor (p75) fusion protein (ENBREL) as a therapy for rheumatoid arthritis. Rheum Dis Clin North Am 24:579–591
46.
Zurück zum Zitat Evans CH, Ghivizzani SC, Robbins PD (2008) Arthritis gene therapy’s first death. Arthritis Res Ther 10:110 Evans CH, Ghivizzani SC, Robbins PD (2008) Arthritis gene therapy’s first death. Arthritis Res Ther 10:110
47.
Zurück zum Zitat Frank KM, Hogarth DK, Miller JL, Mandal S, Mease PJ, Samulski RJ et al (2009) Brief report: investigation of the cause of death in a gene-therapy trial. N Engl J Med 361:161–169 Frank KM, Hogarth DK, Miller JL, Mandal S, Mease PJ, Samulski RJ et al (2009) Brief report: investigation of the cause of death in a gene-therapy trial. N Engl J Med 361:161–169
48.
Zurück zum Zitat Vinatier C, Mrugala D, Jorgensen C, Guicheux J, Noel D (2009) Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 27:307–314 Vinatier C, Mrugala D, Jorgensen C, Guicheux J, Noel D (2009) Cartilage engineering: a crucial combination of cells, biomaterials and biofactors. Trends Biotechnol 27:307–314
49.
Zurück zum Zitat Gelse K, Schneider H (2006) Ex vivo gene therapy approaches to cartilage repair. Adv Drug Deliv Rev 58:259–284 Gelse K, Schneider H (2006) Ex vivo gene therapy approaches to cartilage repair. Adv Drug Deliv Rev 58:259–284
50.
Zurück zum Zitat Lieberman JR, Ghivizzani SC, Evans CH (2002) Gene transfer approaches to the healing of bone and cartilage. Mol Ther 6:141–147 Lieberman JR, Ghivizzani SC, Evans CH (2002) Gene transfer approaches to the healing of bone and cartilage. Mol Ther 6:141–147
51.
Zurück zum Zitat Arai Y, Kubo T, Fushiki S, Mazda O, Nakai H, Iwaki Y et al (2000) Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol 27:979–982 Arai Y, Kubo T, Fushiki S, Mazda O, Nakai H, Iwaki Y et al (2000) Gene delivery to human chondrocytes by an adeno associated virus vector. J Rheumatol 27:979–982
52.
Zurück zum Zitat Ulrich-Vinther M, Maloney MD, Goater JJ, Soballe K, Goldring MB, O’Keefe RJ et al (2002) Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum 46:2095–2104 Ulrich-Vinther M, Maloney MD, Goater JJ, Soballe K, Goldring MB, O’Keefe RJ et al (2002) Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheum 46:2095–2104
53.
Zurück zum Zitat Trippel SB, Ghivizzani SC, Nixon AJ (2004) Gene-based approaches for the repair of articular cartilage. Gene Ther 11:351–359 Trippel SB, Ghivizzani SC, Nixon AJ (2004) Gene-based approaches for the repair of articular cartilage. Gene Ther 11:351–359
54.
Zurück zum Zitat Gelse K, Jiang QJ, Aigner T, Ritter T, Wagner K, Poschl E et al (2001) Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum 44:1943–1953 Gelse K, Jiang QJ, Aigner T, Ritter T, Wagner K, Poschl E et al (2001) Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer. Arthritis Rheum 44:1943–1953
55.
Zurück zum Zitat Cottard V, Valvason C, Falgarone G, Lutomski D, Boissier MC, Bessis N (2004) Immune response against gene therapy vectors: influence of synovial fluid on adeno-associated virus mediated gene transfer to chondrocytes. J Clin Immunol 24:162–169 Cottard V, Valvason C, Falgarone G, Lutomski D, Boissier MC, Bessis N (2004) Immune response against gene therapy vectors: influence of synovial fluid on adeno-associated virus mediated gene transfer to chondrocytes. J Clin Immunol 24:162–169
56.
Zurück zum Zitat Gouze E, Gouze J-N, Palmer GD, Pilapil C, Evans CH, Ghivizzani SC (2007) Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther 15:1114–1120 Gouze E, Gouze J-N, Palmer GD, Pilapil C, Evans CH, Ghivizzani SC (2007) Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther 15:1114–1120
57.
Zurück zum Zitat Madry H, Kaul G, Cucchiarini M, Stein U, Zurakowski D, Remberger K et al (2005) Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12:1171–1179 Madry H, Kaul G, Cucchiarini M, Stein U, Zurakowski D, Remberger K et al (2005) Enhanced repair of articular cartilage defects in vivo by transplanted chondrocytes overexpressing insulin-like growth factor I (IGF-I). Gene Ther 12:1171–1179
58.
Zurück zum Zitat Hidaka C, Goodrich LR, Chen CT, Warren RF, Crystal RG, Nixon AJ (2003) Acceleration of cartilage repair by genetically modified chondrocytes overexpressing bone morphogenetic protein-7. J Orthop Res 21:573–583 Hidaka C, Goodrich LR, Chen CT, Warren RF, Crystal RG, Nixon AJ (2003) Acceleration of cartilage repair by genetically modified chondrocytes overexpressing bone morphogenetic protein-7. J Orthop Res 21:573–583
59.
Zurück zum Zitat Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin K-Q, Okuda K et al (2005) Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum 52:164–170 Yokoo N, Saito T, Uesugi M, Kobayashi N, Xin K-Q, Okuda K et al (2005) Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector. Arthritis Rheum 52:164–170
60.
Zurück zum Zitat Chen H-C, Chang Y-H, Chuang C-K, Lin C-Y, Sung L-Y, Wang Y-H et al (2009) The repair of osteochondral defects using baculovirus-mediated gene transfer with de-differentiated chondrocytes in bioreactor culture. Biomaterials 30:674–681 Chen H-C, Chang Y-H, Chuang C-K, Lin C-Y, Sung L-Y, Wang Y-H et al (2009) The repair of osteochondral defects using baculovirus-mediated gene transfer with de-differentiated chondrocytes in bioreactor culture. Biomaterials 30:674–681
61.
Zurück zum Zitat Zhang XL, Mao ZB, Yu CL (2004) Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res 22:742–750 Zhang XL, Mao ZB, Yu CL (2004) Suppression of early experimental osteoarthritis by gene transfer of interleukin-1 receptor antagonist and interleukin-10. J Orthop Res 22:742–750
62.
Zurück zum Zitat Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R et al (2005) Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A 102:8698–8703 Evans CH, Robbins PD, Ghivizzani SC, Wasko MC, Tomaino MM, Kang R et al (2005) Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A 102:8698–8703
63.
Zurück zum Zitat Grande DA, Mason J, Light E, Dines D (2003) Stem cells as platforms for delivery of genes to enhance cartilage repair. J Bone Joint Surg Am 85A(suppl 2):111–116 Grande DA, Mason J, Light E, Dines D (2003) Stem cells as platforms for delivery of genes to enhance cartilage repair. J Bone Joint Surg Am 85A(suppl 2):111–116
64.
Zurück zum Zitat Gelse K, von der Mark K, Aigner T, Park J, Schneider H (2003) Articular cartilage repair by gene therapy using growth factor- producing mesenchymal cells. Arthritis Rheum 48:430–441 Gelse K, von der Mark K, Aigner T, Park J, Schneider H (2003) Articular cartilage repair by gene therapy using growth factor- producing mesenchymal cells. Arthritis Rheum 48:430–441
65.
Zurück zum Zitat Zhu S, Zhang B, Man C, Ma Y, Hu J (2011) NEL-like molecule-1-modified bone marrow mesenchymal stem cells/poly lactic-co-glycolic acid composite improves repair of large osteochondral defects in mandibular condyle. Osteoarthritis Cartilage 19:743–750 Zhu S, Zhang B, Man C, Ma Y, Hu J (2011) NEL-like molecule-1-modified bone marrow mesenchymal stem cells/poly lactic-co-glycolic acid composite improves repair of large osteochondral defects in mandibular condyle. Osteoarthritis Cartilage 19:743–750
66.
Zurück zum Zitat Tsuchiya H, Kitoh H, Sugiura F, Ishiguro N (2003) Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 301:338–343 Tsuchiya H, Kitoh H, Sugiura F, Ishiguro N (2003) Chondrogenesis enhanced by overexpression of sox9 gene in mouse bone marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 301:338–343
67.
Zurück zum Zitat Lu C-H, Yeh T-S, Yeh C-L, Fang Y-HD, Sung L-Y, Lin S-Y et al (2014) Regenerating cartilages by engineered ASCs: prolonged TGF-β3/BMP-6 expression improved articular cartilage formation and restored zonal structure. Mol Ther 22:186–195 Lu C-H, Yeh T-S, Yeh C-L, Fang Y-HD, Sung L-Y, Lin S-Y et al (2014) Regenerating cartilages by engineered ASCs: prolonged TGF-β3/BMP-6 expression improved articular cartilage formation and restored zonal structure. Mol Ther 22:186–195
68.
Zurück zum Zitat Park J, Gelse K, Frank S, von der Mark K, Aigner T, Schneider H (2006) Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells. J Gene Med 8:112–125 Park J, Gelse K, Frank S, von der Mark K, Aigner T, Schneider H (2006) Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells. J Gene Med 8:112–125
69.
Zurück zum Zitat Shuler FD, Georgescu HI, Niyibizi C, Studer RK, Mi Z, Johnstone B et al (2000) Increased matrix synthesis following adenoviral transfer of a transforming growth factor β1 gene into articular chondrocytes. J Orthop Res 18:585–592 Shuler FD, Georgescu HI, Niyibizi C, Studer RK, Mi Z, Johnstone B et al (2000) Increased matrix synthesis following adenoviral transfer of a transforming growth factor β1 gene into articular chondrocytes. J Orthop Res 18:585–592
70.
Zurück zum Zitat Brower-Toland BD, Saxer RA, Goodrich LR, Mi ZB, Robbins PD, Evans CH et al (2001) Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 12:117–129 Brower-Toland BD, Saxer RA, Goodrich LR, Mi ZB, Robbins PD, Evans CH et al (2001) Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function. Hum Gene Ther 12:117–129
71.
Zurück zum Zitat Obradovic B, Martin I, Padera RF, Treppo S, Freed LE, Vunjak-Novakovic G (2001) Integration of engineered cartilage. J Orthop Res 19:1089–1097 Obradovic B, Martin I, Padera RF, Treppo S, Freed LE, Vunjak-Novakovic G (2001) Integration of engineered cartilage. J Orthop Res 19:1089–1097
72.
Zurück zum Zitat Martin I, Wendt D, Heberer M (2004) The role of bioreactors in tissue engineering. Trends Biotechnol 22:80–86 Martin I, Wendt D, Heberer M (2004) The role of bioreactors in tissue engineering. Trends Biotechnol 22:80–86
73.
Zurück zum Zitat Chen H-C, Hu Y-C (2006) Bioreactors for tissue engineering. Biotechnol Lett 28:1415–1423 Chen H-C, Hu Y-C (2006) Bioreactors for tissue engineering. Biotechnol Lett 28:1415–1423
74.
Zurück zum Zitat Darling EM, Athanasiou KA (2003) Articular cartilage bioreactors and bioprocesses. Tissue Eng 9:9–26 Darling EM, Athanasiou KA (2003) Articular cartilage bioreactors and bioprocesses. Tissue Eng 9:9–26
75.
Zurück zum Zitat Portner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM (2005) Bioreactor design for tissue engineering. J Biosci Bioeng 100:235–245 Portner R, Nagel-Heyer S, Goepfert C, Adamietz P, Meenen NM (2005) Bioreactor design for tissue engineering. J Biosci Bioeng 100:235–245
76.
Zurück zum Zitat Madry H, Padera R, Seidel J, Langer R, Freed LE, Trippel SB et al (2002) Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther 13:1621–1630 Madry H, Padera R, Seidel J, Langer R, Freed LE, Trippel SB et al (2002) Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther 13:1621–1630
77.
Zurück zum Zitat Ho Y-C, Chen H-C, Wang K-C, Hu Y-C (2004) Highly efficient baculovirus-mediated gene transfer into rat chondrocytes. Biotechnol Bioeng 88:643–651 Ho Y-C, Chen H-C, Wang K-C, Hu Y-C (2004) Highly efficient baculovirus-mediated gene transfer into rat chondrocytes. Biotechnol Bioeng 88:643–651
78.
Zurück zum Zitat Chen H-C, Lee H-P, Sung M-L, Liao C-J, Hu Y-C (2004) A novel rotating-shaft bioreactor for two-phase cultivation of tissue-engineered cartilage. Biotechnol Prog 20:1802–1809 Chen H-C, Lee H-P, Sung M-L, Liao C-J, Hu Y-C (2004) A novel rotating-shaft bioreactor for two-phase cultivation of tissue-engineered cartilage. Biotechnol Prog 20:1802–1809
79.
Zurück zum Zitat Chen H-C, Lee H-P, Ho Y-C, Sung M-L, Hu Y-C (2006) Combination of baculovirus-mediated gene transfer and rotating-shaft bioreactor for cartilage tissue engineering. Biomaterials 27:3154–3162 Chen H-C, Lee H-P, Ho Y-C, Sung M-L, Hu Y-C (2006) Combination of baculovirus-mediated gene transfer and rotating-shaft bioreactor for cartilage tissue engineering. Biomaterials 27:3154–3162
80.
Zurück zum Zitat Sung L-Y, Lo W-H, Chiu H-Y, Chen H-C, Chuang C-K, Lee H-P et al (2007) Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression. Biomaterials 28:3437–3447 Sung L-Y, Lo W-H, Chiu H-Y, Chen H-C, Chuang C-K, Lee H-P et al (2007) Modulation of chondrocyte phenotype via baculovirus-mediated growth factor expression. Biomaterials 28:3437–3447
81.
Zurück zum Zitat Smith P, Shuler FD, Georgescu HI, Ghivizzani SC, Johnstone B, Niyibizi C et al (2000) Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 43:1156–1164 Smith P, Shuler FD, Georgescu HI, Ghivizzani SC, Johnstone B, Niyibizi C et al (2000) Genetic enhancement of matrix synthesis by articular chondrocytes: comparison of different growth factor genes in the presence and absence of interleukin-1. Arthritis Rheum 43:1156–1164
82.
Zurück zum Zitat Dinser R, Kreppel F, Zaucke F, Blank C, Paulsson M, Kochanek S et al (2001) Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes. Histochem Cell Biol 116:69–77 Dinser R, Kreppel F, Zaucke F, Blank C, Paulsson M, Kochanek S et al (2001) Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytes. Histochem Cell Biol 116:69–77
83.
Zurück zum Zitat Madry H, Cucchiarini M, Terwilliger EF, Trippel SB (2003) Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14:393–402 Madry H, Cucchiarini M, Terwilliger EF, Trippel SB (2003) Recombinant adeno-associated virus vectors efficiently and persistently transduce chondrocytes in normal and osteoarthritic human articular cartilage. Hum Gene Ther 14:393–402
84.
Zurück zum Zitat Hirschmann F, Verhoeyen E, Wirth D, Bauwens S, Hauser H, Rudert M (2002) Vital marking of articular chondrocytes by retroviral infection using green fluorescence protein. Osteoarthritis Cartilage 10:109–118 Hirschmann F, Verhoeyen E, Wirth D, Bauwens S, Hauser H, Rudert M (2002) Vital marking of articular chondrocytes by retroviral infection using green fluorescence protein. Osteoarthritis Cartilage 10:109–118
85.
Zurück zum Zitat Shakibaei M, Seifarth C, John T, Rahmanzadeh M, Mobasheri A (2006) Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem Pharmacol 72:1382–1395 Shakibaei M, Seifarth C, John T, Rahmanzadeh M, Mobasheri A (2006) Igf-I extends the chondrogenic potential of human articular chondrocytes in vitro: molecular association between Sox9 and Erk1/2. Biochem Pharmacol 72:1382–1395
86.
Zurück zum Zitat Sung L-Y, Chiu H-Y, Chen H-C, Chen Y-L, Chuang C-K, Hu Y-C (2009) Baculovirus-mediated growth factor expression in dedifferentiated chondrocytes accelerates redifferentiation: effects of combinational transduction. Tissue Eng Part A 15:1353–1362 Sung L-Y, Chiu H-Y, Chen H-C, Chen Y-L, Chuang C-K, Hu Y-C (2009) Baculovirus-mediated growth factor expression in dedifferentiated chondrocytes accelerates redifferentiation: effects of combinational transduction. Tissue Eng Part A 15:1353–1362
87.
Zurück zum Zitat Nesic D, Whiteside R, Brittberg M, Wendt D, Martin I, Mainil-Varlet P (2006) Cartilage tissue engineering for degenerative joint disease. Adv Drug Deliv Rev 58:300–322 Nesic D, Whiteside R, Brittberg M, Wendt D, Martin I, Mainil-Varlet P (2006) Cartilage tissue engineering for degenerative joint disease. Adv Drug Deliv Rev 58:300–322
88.
Zurück zum Zitat Chen H-C, Sung L-Y, Lo W-H, Chuang C-K, Wang Y-H, Lin J-L et al (2008) Combination of baculovirus-mediated BMP-2 expression and rotating-shaft bioreactor culture synergistically enhances cartilage formation. Gene Ther 15:309–317 Chen H-C, Sung L-Y, Lo W-H, Chuang C-K, Wang Y-H, Lin J-L et al (2008) Combination of baculovirus-mediated BMP-2 expression and rotating-shaft bioreactor culture synergistically enhances cartilage formation. Gene Ther 15:309–317
89.
Zurück zum Zitat Saini S, Wick TM (2003) Concentric cylinder bioreactor for production of tissue engineered cartilage: effect of seeding density and hydrodynamic loading on construct development. Biotechnol Prog 19:510–521 Saini S, Wick TM (2003) Concentric cylinder bioreactor for production of tissue engineered cartilage: effect of seeding density and hydrodynamic loading on construct development. Biotechnol Prog 19:510–521
90.
Zurück zum Zitat Bueno EM, Bilgen B, Barabino GA (2005) Wavy-walled bioreactor supports increased cell proliferation and matrix deposition in engineered cartilage constructs. Tissue Eng 11:1699–1709 Bueno EM, Bilgen B, Barabino GA (2005) Wavy-walled bioreactor supports increased cell proliferation and matrix deposition in engineered cartilage constructs. Tissue Eng 11:1699–1709
91.
Zurück zum Zitat Carver SE, Heath CA (1999) Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng 62:166–174 Carver SE, Heath CA (1999) Increasing extracellular matrix production in regenerating cartilage with intermittent physiological pressure. Biotechnol Bioeng 62:166–174
92.
Zurück zum Zitat Freed LE, Langer R, Martin I, Pellis NR, VunjakNovakovic G (1997) Tissue engineering of cartilage in space. Proc Natl Acad Sci U S A 94:13885–13890 Freed LE, Langer R, Martin I, Pellis NR, VunjakNovakovic G (1997) Tissue engineering of cartilage in space. Proc Natl Acad Sci U S A 94:13885–13890
93.
Zurück zum Zitat Hoch DH, Grodzinsky AJ, Koob TJ, Albert ML, Eyre DR (1983) Early changes in material properties of rabbit articular cartilage after meniscectomy. J Orthop Res 1:4–12 Hoch DH, Grodzinsky AJ, Koob TJ, Albert ML, Eyre DR (1983) Early changes in material properties of rabbit articular cartilage after meniscectomy. J Orthop Res 1:4–12
94.
Zurück zum Zitat Madry H, Cucchiarini M, Stein U, Remberger K, Kohn D, Trippel SB (2003) Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med 5:502–509 Madry H, Cucchiarini M, Stein U, Remberger K, Kohn D, Trippel SB (2003) Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system. J Gene Med 5:502–509
95.
Zurück zum Zitat Zachos TA, Diggs A, Weisbrode S, Bartlett J, Bertone AL (2007) Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model. Mol Ther 15:1543–1550 Zachos TA, Diggs A, Weisbrode S, Bartlett J, Bertone AL (2007) Mesenchymal stem cell-mediated gene delivery of bone morphogenetic protein-2 in an articular fracture model. Mol Ther 15:1543–1550
96.
Zurück zum Zitat Hanada K, Solchaga LA, Caplan AI, Hering TM, Goldberg VM, Yoo JU et al (2001) BMP-2 induction and TGF-β1 modulation of rat periosteal cell chondrogenesis. J Cell Biochem 81:284–294 Hanada K, Solchaga LA, Caplan AI, Hering TM, Goldberg VM, Yoo JU et al (2001) BMP-2 induction and TGF-β1 modulation of rat periosteal cell chondrogenesis. J Cell Biochem 81:284–294
97.
Zurück zum Zitat Caplan AI, Bruder SP (2001) Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7:259–264 Caplan AI, Bruder SP (2001) Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol Med 7:259–264
98.
Zurück zum Zitat Bruder SP, Jaiswal N, Haynesworth SE (1997) Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 64:278–294 Bruder SP, Jaiswal N, Haynesworth SE (1997) Growth kinetics, self-renewal, and the osteogenic potential of purified human mesenchymal stem cells during extensive subcultivation and following cryopreservation. J Cell Biochem 64:278–294
99.
Zurück zum Zitat Carlberg AL, Pucci B, Rallapalli R, Tuan RS, Hall DJ (2001) Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2. Differentiation 67:128–138 Carlberg AL, Pucci B, Rallapalli R, Tuan RS, Hall DJ (2001) Efficient chondrogenic differentiation of mesenchymal cells in micromass culture by retroviral gene transfer of BMP-2. Differentiation 67:128–138
100.
Zurück zum Zitat Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI et al (1994) Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 76:579–592 Wakitani S, Goto T, Pineda SJ, Young RG, Mansour JM, Caplan AI et al (1994) Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 76:579–592
101.
Zurück zum Zitat Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM (1997) Principles of cartilage repair and regeneration. Clin Orthop 342:254–269 Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM (1997) Principles of cartilage repair and regeneration. Clin Orthop 342:254–269
102.
Zurück zum Zitat Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG et al (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54:3254–3266 Pelttari K, Winter A, Steck E, Goetzke K, Hennig T, Ochs BG et al (2006) Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 54:3254–3266
103.
Zurück zum Zitat Wang W, Li B, Li Y, Jiang Y, Ouyang H, Gao C (2010) In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes. Biomaterials 31:5953–5965 Wang W, Li B, Li Y, Jiang Y, Ouyang H, Gao C (2010) In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes. Biomaterials 31:5953–5965
104.
Zurück zum Zitat Marx JC, Allay JA, Persons DA, Nooner SA, Hargrove PW, Kelly PF et al (1999) High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells. Hum Gene Ther 10:1163–1173 Marx JC, Allay JA, Persons DA, Nooner SA, Hargrove PW, Kelly PF et al (1999) High-efficiency transduction and long-term gene expression with a murine stem cell retroviral vector encoding the green fluorescent protein in human marrow stromal cells. Hum Gene Ther 10:1163–1173
105.
Zurück zum Zitat Gazit D, Turgeman G, Kelley P, Wang E, Jalenak M, Zilberman Y et al (1999) Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med 1:121–133 Gazit D, Turgeman G, Kelley P, Wang E, Jalenak M, Zilberman Y et al (1999) Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med 1:121–133
106.
Zurück zum Zitat Martinek V, Fu FH, Lee CW, Huard J (2001) Treatment of osteochondral injuries – genetic engineering. Clin Sports Med 20:403–416, viii Martinek V, Fu FH, Lee CW, Huard J (2001) Treatment of osteochondral injuries – genetic engineering. Clin Sports Med 20:403–416, viii
107.
Zurück zum Zitat Ho Y-C, Chung Y-C, Hwang S-M, Wang K-C, Hu Y-C (2005) Transgene expression and differentiation of baculovirus-transduced human mesenchymal stem cells. J Gene Med 7:860–868 Ho Y-C, Chung Y-C, Hwang S-M, Wang K-C, Hu Y-C (2005) Transgene expression and differentiation of baculovirus-transduced human mesenchymal stem cells. J Gene Med 7:860–868
108.
Zurück zum Zitat Ho Y-C, Lee H-P, Hwang S-M, Lo W-H, Chen H-C, Chung C-K et al (2006) Baculovirus transduction of human mesenchymal stem cell-derived progenitor cells: variation of transgene expression with cellular differentiation states. Gene Ther 13:1471–1479 Ho Y-C, Lee H-P, Hwang S-M, Lo W-H, Chen H-C, Chung C-K et al (2006) Baculovirus transduction of human mesenchymal stem cell-derived progenitor cells: variation of transgene expression with cellular differentiation states. Gene Ther 13:1471–1479
109.
Zurück zum Zitat Palmer GD, Steinert A, Pascher A, Gouze E, Gouze JN, Betz O et al (2005) Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther 12:219–228 Palmer GD, Steinert A, Pascher A, Gouze E, Gouze JN, Betz O et al (2005) Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther 12:219–228
110.
Zurück zum Zitat Steinert AF, Palmer GD, Pilapil C, Nöth U, Evans CH, Ghivizzani SC (2008) Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A 15:1127–1139 Steinert AF, Palmer GD, Pilapil C, Nöth U, Evans CH, Ghivizzani SC (2008) Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A 15:1127–1139
111.
Zurück zum Zitat Kim HJ, Im GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev 20:2103–2114MathSciNet Kim HJ, Im GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev 20:2103–2114MathSciNet
112.
Zurück zum Zitat Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY et al (2011) Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles. Biomaterials 32:3679–3688 Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, Lim HY et al (2011) Chondrogenesis of human mesenchymal stem cells mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEI-modified PLGA nanoparticles. Biomaterials 32:3679–3688
113.
Zurück zum Zitat Mahmoudifar N, Doran PM (2010) Chondrogenic differentiation of human adipose-derived stem cells in polyglycolic acid mesh scaffolds under dynamic culture conditions. Biomaterials 31:3858–3867 Mahmoudifar N, Doran PM (2010) Chondrogenic differentiation of human adipose-derived stem cells in polyglycolic acid mesh scaffolds under dynamic culture conditions. Biomaterials 31:3858–3867
114.
Zurück zum Zitat Santo VE, Gomes ME, Mano JF, Reis RL (2013) Controlled release strategies for bone, cartilage, and osteochondral engineering-Part II: challenges on the evolution from single to multiple bioactive factor delivery. Tissue Eng Part B Rev 19:327–352 Santo VE, Gomes ME, Mano JF, Reis RL (2013) Controlled release strategies for bone, cartilage, and osteochondral engineering-Part II: challenges on the evolution from single to multiple bioactive factor delivery. Tissue Eng Part B Rev 19:327–352
115.
Zurück zum Zitat Freyria A-M, Mallein-Gerin F (2012) Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors. Injury 43:259–265 Freyria A-M, Mallein-Gerin F (2012) Chondrocytes or adult stem cells for cartilage repair: the indisputable role of growth factors. Injury 43:259–265
116.
Zurück zum Zitat Diekman BO, Estes BT, Guilak F (2010) The effects of BMP6 overexpression on adipose stem cell chondrogenesis: interactions with dexamethasone and exogenous growth factors. J Biomed Mater Res A 93:994–1003 Diekman BO, Estes BT, Guilak F (2010) The effects of BMP6 overexpression on adipose stem cell chondrogenesis: interactions with dexamethasone and exogenous growth factors. J Biomed Mater Res A 93:994–1003
117.
Zurück zum Zitat Im GI, Kim HJ, Lee JH (2011) Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials 32:4385–4392 Im GI, Kim HJ, Lee JH (2011) Chondrogenesis of adipose stem cells in a porous PLGA scaffold impregnated with plasmid DNA containing SOX trio (SOX-5,-6 and -9) genes. Biomaterials 32:4385–4392
118.
Zurück zum Zitat Sophia Fox AJ, Bedi A, Rodeo SA (2009) The basic science of articular cartilage: structure, composition, and function. Sports Health 1:461–468 Sophia Fox AJ, Bedi A, Rodeo SA (2009) The basic science of articular cartilage: structure, composition, and function. Sports Health 1:461–468
119.
Zurück zum Zitat Keeney M, Lai JH, Yang F (2011) Recent progress in cartilage tissue engineering. Curr Opin Biotechnol 25:734–740 Keeney M, Lai JH, Yang F (2011) Recent progress in cartilage tissue engineering. Curr Opin Biotechnol 25:734–740
120.
Zurück zum Zitat Chen J, Chen H, Li P, Diao H, Zhu S, Dong L et al (2011) Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 32:4793–4805 Chen J, Chen H, Li P, Diao H, Zhu S, Dong L et al (2011) Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 32:4793–4805
121.
Zurück zum Zitat Yang HN, Park JS, Woo DG, Jeon SY, Do HJ, Lim HY et al (2011) Chondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes. Biomaterials 32:7695–7704 Yang HN, Park JS, Woo DG, Jeon SY, Do HJ, Lim HY et al (2011) Chondrogenesis of mesenchymal stem cells and dedifferentiated chondrocytes by transfection with SOX Trio genes. Biomaterials 32:7695–7704
Metadaten
Titel
Gene Therapy for Cartilage Tissue Engineering
verfasst von
Yu-Chen Hu
Copyright-Jahr
2014
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-53923-7_4

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