As an essential element in humans, iron is involved in many biochemical reactions; however, it is also known to catalyse the production of highly reactive oxygen species like hydroxyl radicals and superoxide anions, which produce DNA damage in cell free systems (Inoue and Kawanishi, 1987). Since in intact cells iron is mainly bound to storage proteins like ferritin and cellular defense systems exist to detoxify free oxygen radicals, toxic reactions in vivo are prevented to a high degree (for review see Halliwell and Gutteridge, 1984).
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- Genotoxicity of Fe(III)-NTA and its Interaction with other Carcinogenic Metal Compounds
- Springer Berlin Heidelberg