Skip to main content
Erschienen in: Journal of Applied Mathematics and Computing 1-2/2019

05.06.2018 | Original Research

Global stability of an age-structured model for pathogen–immune interaction

verfasst von: Tsuyoshi Kajiwara, Toru Sasaki, Yoji Otani

Erschienen in: Journal of Applied Mathematics and Computing | Ausgabe 1-2/2019

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

In this paper, we present an age-structured mathematical model for infectious disease in vivo with infection age of cells. The model contains an immune variable and the effect of absorption of pathogens into uninfected cells. We construct Lyapunov functionals for the model and prove that the time derivative of the functionals are nonpositive. Using this, we prove the global stability results for the model. Especially, we present the full mathematical detail of the proof of the global stability.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literatur
1.
Zurück zum Zitat Agarwal, R.P., O’Regan, D.: An Introduction to Ordinary Differential Equations. Universitext. Springer, New York (2008)CrossRef Agarwal, R.P., O’Regan, D.: An Introduction to Ordinary Differential Equations. Universitext. Springer, New York (2008)CrossRef
2.
Zurück zum Zitat Anderson, R.M., May, R.M., Gupta, S.: Non-linear phenomena in host-parasite interactions. Parasitology 99, S59–S79 (1989)CrossRef Anderson, R.M., May, R.M., Gupta, S.: Non-linear phenomena in host-parasite interactions. Parasitology 99, S59–S79 (1989)CrossRef
3.
Zurück zum Zitat Browne, C.J., Pilyugin, S.S.: Global analysis of age-structured within-host virus model. Discrete Contin. Dyn. Syst. Ser. B 18, 1999–2017 (2013)MathSciNetCrossRefMATH Browne, C.J., Pilyugin, S.S.: Global analysis of age-structured within-host virus model. Discrete Contin. Dyn. Syst. Ser. B 18, 1999–2017 (2013)MathSciNetCrossRefMATH
4.
Zurück zum Zitat Browne, C.J.: A multi-strain virus model with infected cell age structure: application to HIV. Nonlinear Anal. Real World Appl. 22, 354–372 (2015)MathSciNetCrossRefMATH Browne, C.J.: A multi-strain virus model with infected cell age structure: application to HIV. Nonlinear Anal. Real World Appl. 22, 354–372 (2015)MathSciNetCrossRefMATH
5.
6.
Zurück zum Zitat Demasse, R.D., Ducrot, A.: An age-structured within-host model for multistrain malaria infection. SIAM J. Appl. Math. 73, 572–593 (2013)MathSciNetCrossRefMATH Demasse, R.D., Ducrot, A.: An age-structured within-host model for multistrain malaria infection. SIAM J. Appl. Math. 73, 572–593 (2013)MathSciNetCrossRefMATH
8.
Zurück zum Zitat Huang, G., Liu, X., Takeuchi, Y.: Lyapunov functions and global stability for age-structured HIV infection model. SIAM J. Appl. Math. 72, 25–38 (2012)MathSciNetCrossRefMATH Huang, G., Liu, X., Takeuchi, Y.: Lyapunov functions and global stability for age-structured HIV infection model. SIAM J. Appl. Math. 72, 25–38 (2012)MathSciNetCrossRefMATH
9.
Zurück zum Zitat Inaba, H.: On a new perspective of the basic reproduction number in heterogeneous environment. J. Math. Biol. 65, 309–348 (2012)MathSciNetCrossRefMATH Inaba, H.: On a new perspective of the basic reproduction number in heterogeneous environment. J. Math. Biol. 65, 309–348 (2012)MathSciNetCrossRefMATH
10.
Zurück zum Zitat Inoue, T., Kajiwara, T., Sasaki, T.: Global stability of models of humoral immunity against multiple viral strains. J. Biol. Dyn. 4, 282–295 (2010)MathSciNetCrossRefMATH Inoue, T., Kajiwara, T., Sasaki, T.: Global stability of models of humoral immunity against multiple viral strains. J. Biol. Dyn. 4, 282–295 (2010)MathSciNetCrossRefMATH
11.
Zurück zum Zitat Kajiwara, T., Sasaki, T., Takeuchi, Y.: Construction of Lyapunov functionals for delay differential equations in virology and epidemiology. Nonlinear Anal. Real World Appl. 13, 1802–1826 (2012)MathSciNetCrossRefMATH Kajiwara, T., Sasaki, T., Takeuchi, Y.: Construction of Lyapunov functionals for delay differential equations in virology and epidemiology. Nonlinear Anal. Real World Appl. 13, 1802–1826 (2012)MathSciNetCrossRefMATH
12.
Zurück zum Zitat Kajiwara, T., Sasaki, T., Takeuchi, Y.: Construction of Lyapunov functions of the models for infectious diseases in vivo: from simple models to complex models. Math. Biosci. Eng. 12, 117–133 (2015)MathSciNetMATH Kajiwara, T., Sasaki, T., Takeuchi, Y.: Construction of Lyapunov functions of the models for infectious diseases in vivo: from simple models to complex models. Math. Biosci. Eng. 12, 117–133 (2015)MathSciNetMATH
14.
Zurück zum Zitat Magal, P., McCluskey, C.C., Webb, G.: Lyapunov functional and global asymptotic stability for an infection-age model. Appl. Anal. 89, 1109–1140 (2010)MathSciNetCrossRefMATH Magal, P., McCluskey, C.C., Webb, G.: Lyapunov functional and global asymptotic stability for an infection-age model. Appl. Anal. 89, 1109–1140 (2010)MathSciNetCrossRefMATH
15.
Zurück zum Zitat McCluskey, C.C.: Complete global stability for an SIR epidemic model with delay—distributed or discrete. Nonlinear Anal. Real World Appl. 11, 55–59 (2010)MathSciNetCrossRefMATH McCluskey, C.C.: Complete global stability for an SIR epidemic model with delay—distributed or discrete. Nonlinear Anal. Real World Appl. 11, 55–59 (2010)MathSciNetCrossRefMATH
16.
Zurück zum Zitat Murase, A., Sasaki, T., Kajiwara, T.: Stability analysis of pathogen–immune interaction dynamics. J. Math. Biol. 51, 247–267 (2005)MathSciNetCrossRefMATH Murase, A., Sasaki, T., Kajiwara, T.: Stability analysis of pathogen–immune interaction dynamics. J. Math. Biol. 51, 247–267 (2005)MathSciNetCrossRefMATH
17.
Zurück zum Zitat Nowak, M.A., Bangham, C.R.M.: Population dynamics of immune responses to persistent virus. Science 272, 74–80 (1996)CrossRef Nowak, M.A., Bangham, C.R.M.: Population dynamics of immune responses to persistent virus. Science 272, 74–80 (1996)CrossRef
18.
Zurück zum Zitat Nowak, M.A., May, R.M.: Virus Dynamics. Mathematical Principles of Immunology and Virology. Oxford University Press, Oxford (2000)MATH Nowak, M.A., May, R.M.: Virus Dynamics. Mathematical Principles of Immunology and Virology. Oxford University Press, Oxford (2000)MATH
19.
Zurück zum Zitat Otani, Y., Kajiwara, T., Sasaki, T.: Lyapunov functionals for virus-immune models with infinite delay. Discrete Contin. Dyn. Syst. Ser. B. 20, 3093–3114 (2015)MathSciNetCrossRefMATH Otani, Y., Kajiwara, T., Sasaki, T.: Lyapunov functionals for virus-immune models with infinite delay. Discrete Contin. Dyn. Syst. Ser. B. 20, 3093–3114 (2015)MathSciNetCrossRefMATH
20.
Zurück zum Zitat Pang, H., Wang, W., Wang, K.: Global properties of virus dynamics with CTL immune response. J. Southwest China Normal Univ. 30, 796–799 (2005) Pang, H., Wang, W., Wang, K.: Global properties of virus dynamics with CTL immune response. J. Southwest China Normal Univ. 30, 796–799 (2005)
21.
Zurück zum Zitat Smith, H., Thieme, H.R.: Dynamical Systems and Population Persistence, Graduate Studies in Mathematics, vol. 118. American Mathematical Society, Providence, RI (2011) Smith, H., Thieme, H.R.: Dynamical Systems and Population Persistence, Graduate Studies in Mathematics, vol. 118. American Mathematical Society, Providence, RI (2011)
22.
Zurück zum Zitat Sell, G., You, Y.: Dynamics of Evolutionary Equations, Applied Mathematical Sciences, vol. 143. Springer, New York (2002)CrossRef Sell, G., You, Y.: Dynamics of Evolutionary Equations, Applied Mathematical Sciences, vol. 143. Springer, New York (2002)CrossRef
Metadaten
Titel
Global stability of an age-structured model for pathogen–immune interaction
verfasst von
Tsuyoshi Kajiwara
Toru Sasaki
Yoji Otani
Publikationsdatum
05.06.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Applied Mathematics and Computing / Ausgabe 1-2/2019
Print ISSN: 1598-5865
Elektronische ISSN: 1865-2085
DOI
https://doi.org/10.1007/s12190-018-1194-8

Weitere Artikel der Ausgabe 1-2/2019

Journal of Applied Mathematics and Computing 1-2/2019 Zur Ausgabe