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Über dieses Buch

This Brief focuses on the synthesis, functionalization techniques, optical properties and biomedical application of gold nanostars (GNS). Various facilities of gold nanostars synthesis as well as functionalization of GNS with PEG, organic dyes, bioactive compounds are discussed. The authors discuss physical origin of the Localized Surface Plasmon Resonances and the way the nano-environment affects them. The implication of the LSPR of gold nanostars surface enhanced Raman scattering is also discussed. The emphasis has been done on the application of GNS for current and emerge needs of medicine, biology and pharmacy. Moreover, properties of gold nanostars as contrast agents for in vivo imaging and interaction of GNS with cells are also discussed in this Brief.



Chapter 1. Gold Nanostar Synthesis and Functionalization with Organic Molecules

This chapter is devoted to the synthesis and functionalization of gold nanostars. The physical-chemical characterization and singular features of gold nanostars with respect to other types of gold nanoparticles are provided. Various methods of GNS synthesis as well as of the functionalization of GNS with PEG, organic dyes, and bioactive compounds are discussed.
Piersandro Pallavicini, Elisa Cabrini, Mykola Borzenkov

Chapter 2. Physical Properties of Gold Nanostars

The most relevant applications of gold nanostars are based on their physical properties. These arise primarily from resonant oscillations of the conduction electrons of the nanoparticles called localized surface plasmon resonances (LSPR). In this chapter an introduction to the physical origin of the LSPR and the way the nano-environment affect them are provided. Finally the implication of the LSPR of gold nanostar surface-enhanced Raman scattering is also discussed.
Giuseppe Chirico, Piersandro Pallavicini, Mykola Borzenkov

Chapter 3. Applications of Gold Nanostars: Nanosensing, Thermal Therapy, Delivery Systems

This chapter focuses on the most relevant applications of GNS in life science. The versatility of the GNS functionalization is combined with their optical properties to provide promising and prospective approaches in a variety of biomedical fields. Nanosensing assays, thermal treatments, and delivery systems based on GNS are discussed in this chapter.
Piersandro Pallavicini, Elisa Cabrini, Mykola Borzenkov, Laura Sironi, Giuseppe Chirico

Chapter 4. Interactions of Gold Nanostars with Cells

Unique optical properties, chemical stability, ease of synthesis, and wide functionalization possibilities make GNP attractive candidates for use in biomedical research including chemical sensing, biological imaging, drug delivery, and cancer treatment. In particular, the strong two-photon luminescence of GNP coupled to a specific targeting makes them ideal candidates as contrast agents. To this aim, the interaction with cells and their cellular tracking are important issues for successful application of GNP to biomedical purposes. Properties of gold nanoparticles, namely gold nanostars, as contrast agents and interaction of GNS with cells are highlighted in this chapter.
Laura Sironi, Mykola Borzenkov, Maddalena Collini, Laura D’Alfonso, Margaux Bouzin, Giuseppe Chirico


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