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01.04.2023 | Research paper

Green synthesized magnetic nanoparticles for selective inhibition of osteosarcoma cancer

verfasst von: Rutuja Prashant Gambhir, Shital Kale, Tukaram Dongale, Snehal Patil, Dhanaji Malavekar, Arpita Pandey Tiwari

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2023

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Abstract

Here, selective anti-cancer activity of poly-l-lysine-functionalized iron oxide nanoparticles (PLL@IONPs) has been shown against osteosarcoma cancer. The mentioned nanoparticles were synthesized from Spinacia oleracia (spinach) leaf extract. In-vitro, osteosarcoma cells incubated with the synthesized nanoparticles showed the selective cytotoxicity. Particles exposed to the normal fibroblast cells displayed significantly less cytotoxic effects. Interestingly, the reactive oxygen species (ROS) generation was inhibited by the synthesized material with their intrinsic free radical scavenging activity. In-vivo, PLL@IONPs significantly inhibited the site-specific angiogenesis in chick embryo. This could lead to the site-specific therapeutic efficiency. In addition, suspected carcinogenic dyes were degraded by the particles and provided a cancer-preventive aspect. The results suggest that PLL@IONPs could be significantly applied as a therapeutic against osteosarcoma cancer as well as carcinogen degradation measure.

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Vorheriger Artikel Enhancing electrochemical properties of TiO2 nanotube by incorporation of CdSe quantum dots

Nächster Artikel Formation of quasi-stable nanostructures from L-N-stearoyl glutamic acid and its dimethyl ester on solid surfaces

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Titel: Green synthesized magnetic nanoparticles for selective inhibition of osteosarcoma cancer
verfasst von: Rutuja Prashant Gambhir
Shital Kale
Tukaram Dongale
Snehal Patil
Dhanaji Malavekar
Arpita Pandey Tiwari
Publikationsdatum: 01.04.2023
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 4/2023
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-023-05735-0

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