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01.04.2015 | Research Paper

Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats

verfasst von: Katiane Roversi, Dalila M. Benvegnú, Karine Roversi, Fabíola Trevizol, Luciana T. Vey, Fabiana Elias, Rafael Fracasso, Mariana H. Motta, Roseane F. Ribeiro, Bruna dos S. Hausen, Rafael N. Moresco, Solange C. Garcia, Cristiane B. da Silva, Marilise E. Burger

Erschienen in: Journal of Nanoparticle Research | Ausgabe 4/2015

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Abstract

Haloperidol (HP) nanoencapsulation improves therapeutic efficacy, prolongs the drug action time, and reduces its motor side effects. However, in a view of HP toxicity in organs like liver and kidneys in addition to the lack of knowledge regarding the toxicity of polymeric nanocapsules, our aim was to verify the influence of HP-nanoformulation on toxicity and oxidative stress markers in the liver and kidneys of rats, also observing the damage caused in the blood. For such, 28 adult male Wistar rats were designated in four experimental groups (n = 7) and treated with vehicle (C group), free haloperidol suspension (FH group), blank nanocapsules suspension (B-Nc group), and haloperidol-loaded lipid-core nanocapsules suspension (H-Nc group). The nanocapsules formulation presented the size of approximately 250 nm. All suspensions were administered to the animals (0.5 mg/kg/day-i.p.) for a period of 28 days. Our results showed that FH caused damage in the liver, evidenced by increased lipid peroxidation, plasma levels of aspartate aminotransferase, and alanine aminotransferase, as well as decreased cellular integrity and vitamin C levels. In kidneys, FH treatment caused damage to a lesser extent, observed by decreased activity of δ-aminolevulinate dehydratase (ALA-D) and levels of VIT C. In addition, FH treatment was also related to a higher DNA damage index in blood. On the other hand, animals treated with H-Nc and B-Nc did not show damage in liver, kidneys, and DNA. Our study indicates that the nanoencapsulation of haloperidol was able to prevent the sub-chronic toxicity commonly observed in liver, kidneys, and DNA, thus reflecting a pharmacological superiority in relation to free drug.

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Titel: Haloperidol-loaded lipid-core polymeric nanocapsules reduce DNA damage in blood and oxidative stress in liver and kidneys of rats
verfasst von: Katiane Roversi
Dalila M. Benvegnú
Karine Roversi
Fabíola Trevizol
Luciana T. Vey
Fabiana Elias
Rafael Fracasso
Mariana H. Motta
Roseane F. Ribeiro
Bruna dos S. Hausen
Rafael N. Moresco
Solange C. Garcia
Cristiane B. da Silva
Marilise E. Burger
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 4/2015
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-015-2979-4

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