Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Quality of Life Research
Erschienen in: Quality of Life Research 12/2016

15.06.2016

Health-related quality of life in haemodialysis patients suffering from chronic itch: results from GEHIS (German Epidemiology Haemodialysis Itch Study)

verfasst von: Melanie Weiss, Thomas Mettang, Ulrich Tschulena, Elke Weisshaar

Erschienen in: Quality of Life Research | Ausgabe 12/2016

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Purpose

Chronic itch (CI) is a common symptom in haemodialysis (HD) patients affecting about every 4th HD patient. Though it is known that health-related quality of life (HRQOL) is impaired in HD patients, data are lacking on how CI influences HRQOL in this group of patients, also regarding sex differences and the role of sleep and pain.

Methods

In order to investigate the itch prevalence and to investigate associated factors, GEHIS (German Epidemiology Haemodialysis Itch Study) was established as first cross-sectional study being representative for all dialysis units in Germany by considering their regional distribution and size of the located city according to population. HRQOL of 860 HD patients from a randomly selected cluster sample of 25 dialysis units was investigated using patient-reported outcomes as the Short-Form Health Survey (SF-12), the Hospital Anxiety and Depression Scale (HADS) as well as sleep and pain. Additionally, itch-specific QOL was assessed in HD patients affected by CI using the validated ItchyQoL.

Results

42.8 % of HD patients were female. The mean age was 67.2 years (SD ± 13.5). Female patients showed significantly worse values in the mental component summary of the SF-12 as well as in the HADS subscale anxiety compared to male patients. Itch-specific HRQOL did not subject to sex. Patients with impairments in quality of sleep showed significantly worse values in both the SF-12 and the HADS subscales, however not in the ItchyQoL. The occurrence of pain was significantly associated with impaired SF-12, HADS and the ItchyQoL. Multivariate linear regression showed the itch-specific HRQOL to be significantly impaired with rising severity of CI.

Conclusions

Impairments in HRQOL are a serious problem in HD patients. CI means an additional burden in affected patients, also impairing their HRQOL. GEHIS showed significant sex differences in HRQOL outcomes also in HD patients. CI and pain as well as sleep frequently occur combined and significantly impair HRQOL in HD patients. The care of HD patients should be complemented by psychosocial support and mental health services.
Vorheriger Artikel Health-related quality of life of among elders in rural China: the effect of widowhood
Nächster Artikel Quality-of-life assessment in dementia: the use of DEMQOL and DEMQOL-Proxy total scores

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Mettang, T., & Kremer, A. E. (2015). Uremic pruritus. Kidney International, 87(4), 685–691.CrossRefPubMed
2.
Staender, S., Weisshaar, E., Mettang, T., Szepietowski, J. C., Carstens, E., Ikoma, A., et al. (2007). Clinical classification of itch: A position paper of the International forum for the Study of Itch. Acta Dermato Venereologica, 87(4), 291–294.CrossRef
3.
Weisshaar, E., & Dalgard, F. (2007). Epidemiology of itch: Adding to the burden of skin morbidity. Acta Dermato Venereologica, 89(4), 339–350.CrossRef
4.
Pisoni, R. L., Wikström, B., Elder, S. J., Akizawa, T., Asano, Y., Keen, M. L., et al. (2006). Pruritus in haemodialysis patients: International results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrology, Dialysis, Transplantation, 21(12), 3495–3505.CrossRefPubMed
5.
Kimata, N., Fuller, D. S., Saito, A., Akizawa, T., Fukuhara, S., Pisoni, R. L., et al. (2014). Pruritus in haemodialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study (JDOPPS). Hemodialysis International, 18(3), 657–667.CrossRefPubMed
6.
Weiss, M., Mettang, T., Tschulena, U., Passlick-Deetjen, J., & Weisshaar, E. (2015). Prevalence of chronic itch and associated factors in haemodialysis patients: A representative cross-sectional study. Acta Dermato Venereologica, 95(7), 816–821.PubMed
7.
Lopes, G. B., Nogueira, F. C., de Souza, M. R., Penalva, M. A., de Amorim, J. L., Pisoni, R. L., et al. (2012). Assessment of the psychological burden associated with pruritus in haemodialysis patients using the kidney disease quality of life short form. Quality of Life Research, 21(4), 603–612.CrossRefPubMed
8.
Brekke, F. B., Amro, A., Hortemo Østhus, T. B., Dammen, T., Waldum, B., & Os, I. (2013). Sleep complaints, depression and quality of life in Norwegian dialysis patients. Clinical Nephrology, 80(2), 88–97.CrossRefPubMed
9.
10.
Kang, G. W., Lee, I. H., Ahn, K. S., Lee, J., Ji, Y., & Woo, J. (2015). Clinical and psychosocial factors predicting health-related quality of life in haemodialysis patients. Hemodialysis International, 19, 439–446.CrossRefPubMed
11.
Kini, S. P., DeLong, L. K., Veledar, E., McKenzie-Brown, A. M., Schaufele, M., & Chen, S. C. (2011). The impact of pruritus on quality of life: the skin equivalent of pain. Archives of Dermatology, 147(10), 1153–1156.CrossRefPubMed
12.
Narita, I., Alchi, B., Omori, K., Sato, F., Ajiro, J., Saga, D., et al. (2006). Etiology and prognostic significance of severe uremic pruritus in chronic haemodialysis patients. Kidney International, 69(9), 1626–1632.CrossRefPubMed
13.
Einollahi, B., Motalebi, M., Rostami, Z., Nemati, E., & Salesi, M. (2015). Sleep quality among Iranian haemodialysis patients: a multicenter study. Nephro-Urology Monthly, 7(1), e23849.PubMed
14.
Krause, K., Kessler, B., Weller, K., Veidt, J., Chen, S. C., Martus, P., et al. (2013). German version of ItchyQoL: Validation and initial clinical findings. Acta Dermato Venereologica, 93(5), 562–568.CrossRefPubMed
15.
Manns, B., Hemmelgarn, B., Lillie, E., Dip, S. G., Cyr, A., Gladish, M., et al. (2014). Setting research priorities for patients on or nearing dialysis. Clinical Journal of the American Society of Nephrology, 9(10), 1813–1821.CrossRefPubMedPubMedCentral
16.
Ware, J., Kosinski, M., & Keller, S. D. (1996). A 12-Item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Medical Care, 34(3), 220–233.CrossRefPubMed
17.
18.
Zigmond, A., & Snaith, R. P. (1983). The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica, 67(6), 361–370.CrossRefPubMed
19.
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987). A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. Journal of Chronic Diseases, 40(5), 373–383.CrossRefPubMed
20.
Hemmelgarn, B. R., Manns, B. J., Quan, H., & Ghali, W. A. (2003). Adapting the Charlson comorbidity index for use in patients with ESRD. American Journal of Kidney Disease, 42(1), 125–132.CrossRef
21.
Weisshaar, E., Weiss, M., Passlick-Deetjen, J., Tschulena, U., Maleki, K., & Mettang, T. (2015). Laboratory and dialysis characteristics in haemodialysis patients suffering from chronic itch—Results from a representative cross-sectional study. BMC Nephrology, 16(1), 184.CrossRefPubMedPubMedCentral
22.
Phan, N. Q., Blome, C., Fritz, F., Gerss, J., Reich, A., Ebata, T., et al. (2012). Assessment of pruritus intensity: Prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus. Acta Dermato Venereologica, 92(5), 502–507.CrossRefPubMed
23.
Reich, A., Heisig, M., Phan, N. Q., Taneda, K., Takamori, K., Takeuchi, S., et al. (2012). Visual analogue scale: Evaluation of the instrument for the assessment of pruritus. Acta Dermato Venereologica, 92(5), 497–501.CrossRefPubMed
24.
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gotzsche, P. C., & Vandenbroucke, J. P. (2007). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Epidemiology, 18(6), 800–804.CrossRef
25.
Belayev, L. Y., Mor, M. K., Sevick, M. A., Shields, A. M., Rollman, B. L., Palevsky, P. M., et al. (2015). Longitudinal associations of depressive symptoms and pain with quality of life in patients receiving chronic haemodialysis. Hemodialysis International, 19(2), 216–224.CrossRefPubMed
26.
Ibrahim, N., Chiew-Thong, N. K., Desa, A., & Razali, R. (2013). Depression and coping in adults undergoing dialysis for end-stage renal disease. Asia-Pacific Psychiatry, 5(1), 35–40.CrossRefPubMed
27.
Saeed, Z., Ahmad, A. M., Shakoor, A., Ghafoor, F., & Kanwal, S. (2012). Depression in patients on haemodialysis and their caregivers. Saudi Journal of Kidney Diseases and Transplantation, 23(5), 946–952.CrossRefPubMed
28.
Olagunju, A. T., Campbell, E. A., & Adeyemi, J. D. (2015). Interplay of anxiety and depression with quality of life in endstage renal disease. Psychosomatics, 56(1), 67–77.CrossRefPubMed
29.
Kosmadakis, G. C., & Medcalf, J. F. (2008). Sleep disorders in dialysis patients. The International Journal of Artificial Organs, 31(11), 919–927.PubMed
30.
31.
Weiss, M., & Weisshaar, E. (2014). Qualitative interviews on chronic pruritus in haemodialysis patients. Acta Dermato Venereologica, 94(6), 713–714.CrossRefPubMed
32.
Carr, C. W., Veledar, E., & Chen, S. C. (2014). Factors mediating the impact of chronic pruritus on quality of life. JAMA Dermatology, 150(6), 613–620.CrossRefPubMed
33.
Yamamoto, Y., Hayashino, Y., Yamazaki, S., Akiba, T., Akizawa, T., Asano, Y., et al. (2009). Depressive symptoms predict the future risk of severe pruritus in haemodialysis patients: Japan dialysis outcomes and practice patterns study. British Journal of Dermatology, 161(2), 384–389.CrossRefPubMed
34.
Cohen, J. (1988). Statistical power analysis for the behavioral sciences. Hillsdale, NJ: L. Erlbaum Associates.
35.
Dalgard, F., Dawn, A. G., & Yosipovitch, G. (2007). Are itch and chronic pain associated in adults? Results of a large population survey in Norway. Dermatology, 214(4), 305–309.CrossRefPubMed
36.
Patel, S. S. (2013). Treating pain to improve quality of life in end-stage renal disease. Seminars in Dialysis, 26(3), 268–273.CrossRefPubMed
37.
Santoro, D., Satta, E., Messina, S., Constantino, G., Savica, V., & Bellinghieri, G. (2013). Pain in end-stage renal disease: A frequent and neglected clinical problem. Clinical Nephrology, 79(1), S2–S11.PubMed
38.
Akiyama, T., & Carstens, E. (2014). Spinal Coding of Itch and Pain. In E. Carstens & T. Akiyama (Eds.), Itch: Mechanisms and treatment (chapter 19). Boca Raton, Florida: CRC Press.
39.
Schmelz, M. (2015). Itch and pain differences and commonalities. In H. G. Schaible (Ed.), Pain control, handbook of experimental pharmacology (pp. 285–301). Berlin, Heidelberg: Springer.
40.
Lopes, A., Bragg, A. J., Young, E., Goodkin, D., Mapes, D., & Combe, C. (2002). Depression as a predictor of mortality and hospitalization among haemodialysis patients in the United States and Europe. Kidney International, 62(1), 199–207.CrossRefPubMed
41.
Mapes, D. L., Lopes, A. A., Satayathum, S., McCullough, K. P., Goodkin, D. A., & Locatelli, F. (2003). Health-related quality of life as a predictor of mortality and hospitalization: The Dialysis Outcomes and Practice Patterns Study (DOPPS). Kidney International, 64(1), 339–349.CrossRefPubMed
Metadaten
Titel
Health-related quality of life in haemodialysis patients suffering from chronic itch: results from GEHIS (German Epidemiology Haemodialysis Itch Study)
verfasst von
Melanie Weiss
Thomas Mettang
Ulrich Tschulena
Elke Weisshaar
Publikationsdatum
15.06.2016
Verlag
Springer International Publishing
Erschienen in
Quality of Life Research / Ausgabe 12/2016
Print ISSN: 0962-9343
Elektronische ISSN: 1573-2649
DOI
https://doi.org/10.1007/s11136-016-1340-4

Weitere Artikel der Ausgabe 12/2016

Quality of Life Research 12/2016 Zur Ausgabe

OriginalPaper

The e-MSWS-12: improving the multiple sclerosis walking scale using item response theory

OriginalPaper

Associations between daily physical activity, handgrip strength, muscle mass, physical performance and quality of life in prefrail and frail community-dwelling older adults

OriginalPaper

Three-year trajectories of global perceived quality of life for youth with chronic health conditions

OriginalPaper

Health-related quality of life of among elders in rural China: the effect of widowhood

Review

Reporting and dealing with missing quality of life data in RCTs: has the picture changed in the last decade?

OriginalPaper

Stigma as a key determinant of health-related quality of life in Parkinson’s disease