Substance P (SP) evokes a vasodepressor effect when injected into the systemic circulation. This action is assumed to be due to a decrease in systemic vascular resistance since SP relaxes the dog isolated carotid artery  and increases blood flow in various vascular beds . At doses above the ED50, SP causes greater lowering of systolic than of diastolic blood pressure (BP) suggesting that high doses affect preload as well as after load. At still higher doses SP will evoke a pressor response  suggesting that SP is capable of increasing peripheral vascular resistance. The present study was directed at determining the effect of a high dose of SP on cardiovascular dynamics with the aim of determining its action on systemic vascular resistance and cardiac preload.
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- Hemodynamic Actions of Substance P in Anesthetized Rats
J. C. Hancock
- Springer New York
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