2005 | OriginalPaper | Buchkapitel
Hierarchical Multi-classification with Predictive Clustering Trees in Functional Genomics
verfasst von : Jan Struyf, Sašo Džeroski, Hendrik Blockeel, Amanda Clare
Erschienen in: Progress in Artificial Intelligence
Verlag: Springer Berlin Heidelberg
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
This paper investigates how predictive clustering trees can be used to predict gene function in the genome of the yeast
Saccharomyces cerevisiae
. We consider the MIPS FunCat classification scheme, in which each gene is annotated with one or more classes selected from a given functional class hierarchy. This setting presents two important challenges to machine learning: (1) each instance is labeled with a set of classes instead of just one class, and (2) the classes are structured in a hierarchy; ideally the learning algorithm should also take this hierarchical information into account. Predictive clustering trees generalize decision trees and can be applied to a wide range of prediction tasks by plugging in a suitable distance metric. We define an appropriate distance metric for hierarchical multi-classification and present experiments evaluating this approach on a number of data sets that are available for yeast.