A case of human adrenal pheochromocytoma, containing elevated concentration of substance P-like immunoreactivity (SP-LI) (217 pmol/g) is described. In the peripheral plasma, however, SP-LI was (8.2 pmol/l) similar to normal controls. HPLC of pheochromocytoma tissue extract revealed the presence of a major immunoreactive fraction eluting as authentic SP. Immunohistochemistry showed that approximately 30% of chromaffin cells were positive for SP-LI. We confirm that SP can be included among the various peptides which may be synthesized by pheochromocytoma.
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- HPLC and Immunohistochemical Characterization of Substance P-Like Immunoreactivity in a Human Pheochromocytoma
M. G. Spillantini
- Springer New York
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