Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
The International Journal of Life Cycle Assessment
Erschienen in: The International Journal of Life Cycle Assessment 10/2016

25.04.2016 | LCIA OF IMPACTS ON HUMAN HEALTH AND ECOSYSTEMS

Human health characterization factors of nano-TiO2 for indoor and outdoor environments

verfasst von: Martina Pini, Beatrice Salieri, Anna Maria Ferrari, Bernd Nowack, Roland Hischier

Erschienen in: The International Journal of Life Cycle Assessment | Ausgabe 10/2016

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Purpose

The increasing use of engineered nanomaterials (ENMs) in industrial applications and consumer products is leading to an inevitable release of these materials into the environment. This makes it necessary to assess the potential risks that these new materials pose to human health and the environment. Life cycle assessment (LCA) methodology has been recognized as a key tool for assessing the environmental performance of nanoproducts. Until now, the impacts of ENMs could not be included in LCA studies due to a lack of characterization factors (CFs). This paper provides a methodological framework for identifying human health CFs for ENMs.

Methods

The USEtox™ model was used to identify CFs for assessing the potential carcinogenic and non-carcinogenic effects on human health caused by ENM emissions in both indoor (occupational settings) and outdoor environments. Nano-titanium dioxide (nano-TiO2) was selected for defining the CFs in this study, as it is one of the most commonly used ENMs. For the carcinogenic effect assessment, a conservative approach was adopted; indeed, a critical dose estimate for pulmonary inflammation was assumed.

Results and discussion

We propose CFs for nano-TiO2 from 5.5E−09 to 1.43E−02 cases/kgemitted for both indoor and outdoor environments and for carcinogenic and non-carcinogenic effects.

Conclusions

These human health CFs for nano-TiO2 are an important step toward the comprehensive application of LCA methodology in the field of nanomaterial technology.
Vorheriger Artikel An environmental life cycle assessment of forklift operation: a well-to-wheel analysis
Nächster Artikel Characterization model to assess ocean acidification within life cycle assessment

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Anhänge
Nur mit Berechtigung zugänglich
Literatur
Al-Kattan A, Wichser A, Zuin S, Arroyo Y, Golanski L, Ulrich A, Nowack B (2014) Behavior of TiO2 released from nano-TiO2-containing paint and comparison to pristine nano-TiO2. Environ Sci Technol 48:6710–6718CrossRef
Arvidsson R, Molander S, Sandén BA, Hassellöv M (2011) Challenges in exposure modeling of nanoparticles in aquatic environments. Hum Ecol Risk Assess 17(1):245–262CrossRef
Bermudez E, Mangum JB, Wong BA, Asgharian B, Hext PM, Warheit DB, Everitt JI (2004) Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci 77:347–357CrossRef
Bessems JG, Loizou G, Krishnan K, Clewell HJ III, Bernasconi C, Bois F, Coecke S, Collnot E-M, Diembeck W, Farcal LR, Liesbeth G, Gundert-Remy U, Kramer N, Küsters G, Leite SB, Pelkonen OR, Schöder K, Testai E, Zasadna IW, Zaldívar-Comenges JM (2014) PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA–EURL ECVAM ADME workshop. Regul Toxicol Pharmacol 68(1):119–139CrossRef
Brouwer D (2010) Exposure to manufactured nanoparticles in different workplaces. Toxicology 269(2):120–127CrossRef
Donaldson K, Stone V, Tran CL, Kreyling W, Borm PJA (2004) Nanotoxicology. Occup Environ Med 61:727–728CrossRef
DPR MT-2. Guidance for Benchmark Dose (BMD) Approach-continuous data. (2004) Medical Toxicology Branch, Department of Pesticide Regulation, California Environmental Protection Agency, Sacramento, CA
Eckelman MJ, Mauter MS, Isaacs JA, Elimelech M (2012) New perspectives on nanomaterial aquatic ecotoxicity: production impacts exceed direct exposure impacts for carbon nanotubes. Environ Sci Technol 46:2902–2910CrossRef
Everitt JI, Mangu JB, Bermudez E, Wong BA, Asgharian B, Reverdy EE, Hext PM, Warheit DB (2000) Comparison of selected pulmonary responses of rats, mice and Syrian golden hamsters to inhaled pigmentary titanium dioxide. Inhal Toxicol 12(Suppl 3):275–282CrossRef
Farcal L, Torres Andón F, Di Cristo L, Rotoli BM, Bussolati O, Bergamaschi E et al (2015) Comprehensive in vitro toxicity testing of a panel of representative oxide nanomaterials: first steps towards an intelligent testing strategy. PLoS ONE 10(5), e0127174. doi:10.​1371/​journal.​pone.​0127174 CrossRef
Garcia GR, Zimmermann B, Weil M (2014) Nanotoxicity and life cycle assessment: first attempt towards the determination of characterization factors for carbon nanotubes. IOP Conf. Series: Material Science and Engineering, 64. doi:10.​1088/​1757-899X/​64/​1/​012029
Garner K, Keller A (2014) Emerging patterns for engineered nanomaterials in the environment: a review of fate and toxicity studies. J Nanoparticle Res 16:1–28CrossRef
Heinrich U, Fuhst R, Rittinghausen S, Creutzenberg O, Bellmann B, Koch W, Levsen K (1995) Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal Toxicol 7(4):533–556CrossRef
Hellweg S, Demou E, Bruzzi R, Meijer A, Rosenbaum RK, Huijbregts MA, McKone TE (2009) Integrating human indoor air pollutant exposure within life cycle impact assessment. Environ Sci Technol 43(6):1670–1679CrossRef
Henderson AD, Hauschild MZ, van de Meent D, Huijbregts MAJ, Larsen HF, Margni M, McKone TE, Payet J, Rosenbaum RK, Jolliet O (2011) USEtox fate and ecotoxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties. Int J LCA 16(8):701–709. doi:10.​1007/​s11367-011-0294-6
Hirsch C, Roesslein M, Krug HF, Wick P (2011) Nanomaterial cell interactions: are current in vitro tests reliable? Nanomedicine 6(5):837–847CrossRef
Hischier R (2014) Framework for LCI modelling of nanoparticle releases along the life cycle. Int J Life Cycle Assess 19(4):838–849CrossRef
Hischier R, Walser T (2012) Life cycle assessment of engineered nanomaterials: state of the art and strategies to overcome existing gaps. Sci Total Environ 425:271–282CrossRef
Hischier R, Nowack B, Gottschalk F, Hincapie I, Steinfeldt M, Som C (2015) Life cycle assessment of façade coating systems containing manufactured nanomaterials. J Nanoparticle Res. doi:10.​1007/​s11051-015-2881-0
Hofstetter P (1998) Perspectives in life cycle impact assessment: a structured approach to combine models of the technosphere, ecosphere and valuesphere. Kluwer, Dordrecht, p 484CrossRef
Huijbregts MA, Rombouts LJ, Ragas AM, van de Meent D (2005) Human‐toxicological effect and damage factors of carcinogenic and noncarcinogenic chemicals for life cycle impact assessment. Integr Environ Assess Manag 1(3):181–244CrossRef
Humbert S, Marshall JD, Shaked S, Spadaro JV, Nishioka Y, Preiss P, McKone TE, Horvath A, Jolliet O (2011) Intake fraction for particulate matter: recommendations for life cycle impact assessment. Environ Sci Technol 45(11):4808–4816CrossRef
Iavicoli I, Leso V, Fontana L, Bergamaschi A (2011) Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. Eur Rev Med Pharmacol Sci 15:481–508
JRC-IES (European Commission-Joint Research Centre-Institute for Environment and Sustainability) (2010) International Reference Life Cycle Data System (ILCD) Handbook—general guide for life cycle assessment—detailed guidance. First edition March 2010. EUR 24708 EN. Luxembourg. Publications Office of the European Union
Kahru A, Ivask A (2013) Mapping the dawn of nanoecotoxicological research. Acc Chem Res 46:823–833CrossRef
Kaiser J-P, Roesslein M, Diener L, Wick P (2013) Human health risk of ingested nanoparticles that are added as multifunctional agents to paints: an in vitro study. PLoS One 8, e83215CrossRef
Klaine SJ, Alvarez PJJ, Batley GE, Fernandes TF, Handy RD, Lyon DY, Mahendra S, McLaughlin MJ, Lead JR (2008) Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environ Toxicol Chem 27:1825–1851CrossRef
Krishnan K, Peyret T (2009) Physiologically based toxicokinetic (PBTK) modeling in ecotoxicology. In: Devillers J (ed) Ecotoxicology modeling, Dordrecht, pp 145–175
Krug HF, Wick P (2011) Nanotoxicology: an interdisciplinary challenge. Angew Chem Int Ed 50:1260–1278CrossRef
Kuhlbusch TA, Asbach C, Fissan H, Göhler D, Stintz M (2011) Nanoparticle exposure at nanotechnology workplaces: a review. Part Fibre Toxicol 8(1):22CrossRef
Landsiedel R, Ma‐Hock L, Kroll A, Hahn D, Schnekenburger J, Wiench K, Wohlleben W (2010) Testing metal‐oxide nanomaterials for human safety. Adv Mater 22(24):2601–2627CrossRef
Landsiedel R, Ma-Hock L, Hofmann T et al (2014) Application of short-term inhalation studies to assess the inhalation toxicity of nanomaterials. Part Fibre Toxicol 11:16CrossRef
Lee JH, Kwon M, Ji JH, Kang CS, Ahn KH, Han JH, Yu IJ (2011) Exposure assessment of workplaces manufacturing nanosized TiO2 and silver. Inhal Toxicol 23(4):226–236CrossRef
Liu H, Cohen Y (2014) Multimedia environmental distribution of engineered nanomaterials. Environ Sci Technol 48:3281–3292CrossRef
Meesters JAJ, Koelmans AA, Quik JTK, Hendriks AJ, van de Meent D (2014) Multimedia modeling of engineered nanoparticles with SimpleBox4nano: model definition and evaluation. Environ Sci Technol 48:5726–5736CrossRef
Miseljic M, Olsen SI (2014) Life-cycle assessment of engineered nanomaterials: a literature review of assessment status. J Nanoparticle Res 16(6):1–33CrossRef
NIOSH (National Institute for Occupational Safety and Health) (2011) Occupational exposure to titanium dioxide. In Current Intelligence Bulletin 63
Notter D (2015) Life cycle impact assessment modeling for particulate matter: a new approach based on physico-chemical particle properties. Environ Int 82:10–20CrossRef
Pini M, Gamberini R, Neri P, Rimini B, Ferrari AM (2012) Life cycle assessment of a self-cleaning coating based on nano TiO2-polyurea resin applied on an aluminum panel (n°O8a-7). International Conference on Safe production and use of nanomaterials, Nanosafe, November 13-15, 2012, Grenoble, France
Pini M, Cedillo González EI, Neri P, Siligardi C, Ferrari AM (2013) Life cycle assessment of nanoTiO2 coated self-cleaning float glass (n°1256). Proceeding of Nanotech, May 12 – 16, 2013, Washington DC, US. ISBN 978-1-4822-0604-3
Pini M, Neri P, Montecchi R, Ferrari AM (2014) Life cycle assessment of nano-TiO2 functionalized porcelainized stoneware tiles. Proceedings of the 247th ACS National Meeting, March 16 – 20, Dallas, TX, US. www.​acs.​org/​dallas2014
Pini M, Rosa R, Neri P, Bondioli F, Ferrari AM (2015) Environmental assessment of a bottom-up hydrolytic synthesis of TiO2 nanoparticles. Green Chem 17(1):518–531CrossRef
Praetorius A, Scheringer M, Hungerbühler K (2012) Development of environmental fate models for engineered nanoparticles: a case study of TiO2 nanoparticles in the Rhine River. Environ Sci Technol 46(12):6705–6713CrossRef
Praetorius A, Tufenkji N, Goss K-U, Scheringer M, von der Kammer F, Elimelech M (2014) The road to nowhere: equilibrium partition coefficients for nanoparticles. Environ Sci: Nano 1:317–323
Rosenbaum RK, Margni M, Jolliet O (2007) A flexible matrix algebra framework for the multimedia multipathway modeling of emission to impacts. Environ Int 33:624–634CrossRef
Rosenbaum RK, Bachmann TM, Gold LS, Huijbregts MA, Jolliet O, Juraske R, Koehler A, Larsen HF, MacLeod M, Margni M, McKone TE, Payet J, Schuhmacher M, van de Meent D, Hauschil MZ (2008) USEtox—the UNEP-SETAC toxicity model: recommended characterisation factors for human toxicity and freshwater ecotoxicity in life cycle impact assessment. Int J Life Cycle Assess 13(7):532–546CrossRef
Rosenbaum RK, Huijbregts MAJ, Henderson AD, Margni M, McKone TE, van de Meent D, Hauschild MZ, Shaked S, Li DS, Gold LS, Jolliet O (2011) USEtox human exposure and toxicity factors for comparative assessment of toxic emissions in life cycle analysis: sensitivity to key chemical properties. Int J Life Cycle Assess 16:710–727CrossRef
Sala S, Marinov D, Anna K, Margni M, Humbert S, Olivier J, Shanna S, Pennington D (2011) Life cycle impact assessment of chemicals: relevance and feasibility of spatial differentiation for ecotoxicity and human toxicity impact assessment. Life Cycle Management Conference 2011. Available at http://​www.​lcm2011.​org/​papers.​html
Salieri B, Righi S, Pasteris A, Olsen SI (2015) Freshwater ecotoxicity characterisation factor for metal oxide nanoparticles: a case study on titanium dioxide nanoparticle. Sci Total Environ 505:494–502CrossRef
SCCS (Scientific Committee on Consumer Safety) (2013) Opinion on titanium dioxide (nano form)
SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks) (2010) Opinion on the scientific basis for the definition of the term “nanomaterial”
Simkó M, Mattsson MO (2010) Risks from accidental exposures to engineered nanoparticles and neurological health effects: a critical review. Part Fibre Toxicol 7(1):1
Smulders S, Luyts K, Brabants G, Landuyt KV, Kirschhock C, Smolders E, Golanski L, Vanoirbeek J, Hoet PH (2014) Toxicity of nanoparticles embedded in paints compared with pristine nanoparticles in mice. Toxicol Sci 141:132–140CrossRef
Som C, Berges M, Chaudhry Q, Dusinska M, Fernandes TF, Olsen SI, Nowack B (2010) The importance of life cycle concepts for the development of safe nanoproducts. Toxicology 269:160–169CrossRef
Sun TY, Gottschalk F, Hungerbühler K, Nowack B (2014) Comprehensive probabilistic modelling of environmental emissions of engineered nanomaterials. Environ Pollut 185:69–76CrossRef
Walser T, Limbach LK, Brogioli R et al (2012) Persistence of engineered nanoparticles in a municipal solid-waste incineration plant. Nat Nanotechnol 7(8):520–524CrossRef
Walser T, Meyer D, Fransman W, Buist H, Kuijpers E, Brouwer D (2015) Life-cycle assessment framework for indoor emissions of synthetic nanoparticles. J Nanoparticle Res 17(6):1–18CrossRef
Wang J, Fan Y (2014) Lung injury induced by TiO2 nanoparticles depends on their structural features: size, shape, crystal phases, and surface coating. Int J Mol Sci 15(12):22258–22278CrossRef
Wittmaack K (2007) In search of the most relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ Health Perspect 115:187–194CrossRef
Xu X, Zhou X, Ma L, Mo M, Ren C, Pan R (2014) One-step microemulsion-mediated hydrothermal synthesis of nanocrystalline TiO2. World J Nano Sci Eng 4:29–34CrossRef
Metadaten
Titel
Human health characterization factors of nano-TiO2 for indoor and outdoor environments
verfasst von
Martina Pini
Beatrice Salieri
Anna Maria Ferrari
Bernd Nowack
Roland Hischier
Publikationsdatum
25.04.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
The International Journal of Life Cycle Assessment / Ausgabe 10/2016
Print ISSN: 0948-3349
Elektronische ISSN: 1614-7502
DOI
https://doi.org/10.1007/s11367-016-1115-8

Weitere Artikel der Ausgabe 10/2016

The International Journal of Life Cycle Assessment 10/2016 Zur Ausgabe

LCA FOR ENERGY SYSTEMS AND FOOD PRODUCTS

Life cycle assessment of renewable diesel production from lignocellulosic biomass

LCIA OF IMPACTS ON HUMAN HEALTH AND ECOSYSTEMS

Characterization model to assess ocean acidification within life cycle assessment

EXERGY AND LCA

Improved exergetic life cycle assessment through matrix reduction technique

POLICIES AND SUPPORT IN RELATION TO LCA

Perceptions on LCA implementation: evidence from a survey on adopters and nonadopters in Italy

IN MEMORIAM

Bill and Marge Franklin

LCA FOR ENERGY SYSTEMS AND FOOD PRODUCTS

Life cycle assessment of heat production from underground coal gasification