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01.06.2020 | Research paper

In vivo carcinogenicity study of silver nanoparticles in transgenic rasH2 mice by one single-dose intravenous administration

verfasst von: Ying Liu, Susu Liu, Meiyu Wu, Jianjun Lv, Yanwei Yang, Mo Dan, Lin Liu, Liang Chen, Xiaochun Wu, Changfa Fan, Liming Xu, Liming Xie

Erschienen in: Journal of Nanoparticle Research | Ausgabe 6/2020

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Abstract

Benefited from their broad-spectrum antimicrobial property, silver nanoparticles (AgNPs) have been widely used in various daily life and medical products. Consequently, the bio-safety of AgNPs, especially long-term in vivo biological effects is of more and more importance. However, there are no correlated publications about AgNP carcinogenicity at present. Thus, in this study, we have investigated the potential carcinogenicity of polyvinylpyrrolidone (PVP)-coated AgNPs with an intermediate size (diameter ~ 42.5 nm). The C57-ras transgenic mouse model (CB6F1 Tg mice) harboring human c-Ha-ras gene was used to shorten the duration of in vivo experiments from 2 years to 22 weeks. CB6F1 Tg mice were intravenously injected by different single doses of AgNPs (0.4, 4, and 20 mg/kg body weight) during the 22-week carcinogenicity study. There were no obvious AgNP-related neoplastic lesions by microscope examination and no increase in the incidence of non-neoplastic lesions in the AgNP-treated mice in our study. Overall, these results indicate that AgNPs (≤ 20 mg/kg) do not cause carcinogenesis in CB6F1 Tg mice via a single-dose intravenous injection. This provides useful toxicological information and is of great importance to more applications of AgNPs in the future.

Vorheriger Artikel Structures and properties of [Ag(Ag2S)n]+ clusters with n = 1–9: a density functional theory study

Nächster Artikel Optimization of magnetic fluid hyperthermia with respect to nanoparticle shape-related parameters: case of magnetite ellipsoidal nanoparticles

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Titel: In vivo carcinogenicity study of silver nanoparticles in transgenic rasH2 mice by one single-dose intravenous administration
verfasst von: Ying Liu
Susu Liu
Meiyu Wu
Jianjun Lv
Yanwei Yang
Mo Dan
Lin Liu
Liang Chen
Xiaochun Wu
Changfa Fan
Liming Xu
Liming Xie
Publikationsdatum: 01.06.2020
Verlag: Springer Netherlands
Erschienen in: Journal of Nanoparticle Research / Ausgabe 6/2020
Print ISSN: 1388-0764
Elektronische ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-020-04836-4

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