Until the recent discovery of two decapeptides, neurokinin A (NKA) and neurokinin B(NKB), substance P (SP) was the only tachykinin identified in mammalian tissues [1,2,3]. A common precursor for SP and NKA has been identified in bovine striatum  and the mRNA coding for these peptides has been found in sensory neurones  Using radiolabelled amino acids, co-synthesis of NKA and SP in rat sensory ganglia has been demonstrated . It appears that SP and NKA are co-localized in certain primary afferent neurones while NKB is localized in interneurones or ascending pathways rather than in primary afferents . The role of SP, released from the peripheral terminals of sensory C-fibres in the skin, has been studied in detail and there is convincing evidence for its involvement in antidromic vasodilatation and plasma protein extravasation . It is likely, however, that a part of the neurogenic vascular responses that are now attributed to SP may, in fact, be mediated by other tachykinins.
Weitere Kapitel dieses Buchs durch Wischen aufrufen
- Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat
- Springer New York
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