Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Bücher
Zeitschriften
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
SLX-Digitalkonferenz: Zukunftswerkstatt 2024

Mehr Umsatz mit Top-Kontakten

Am 7. Mai erfahren Sie, wie Vertriebsteams Leadgenerierung, Leadnurturing und Leadstrategien effizient steuern können.
Erweiterte Suche
Anmelden
nach oben
Erschienen in:
Introduction to Application of Biomedical Engineering in Dentistry Kapitel lesen Erstes Kapitel lesen

2020 | OriginalPaper | Buchkapitel

17. Injectable Gels for Dental and Craniofacial Applications

verfasst von : Mohamed S. Ibrahim, Noha A. El-Wassefy, Dina S. Farahat

Erschienen in: Applications of Biomedical Engineering in Dentistry

Verlag: Springer International Publishing

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

The use of injectable scaffolds is considered a promising approach in craniofacial tissue regeneration, as they can be introduced with minimally invasive surgery, thus reducing the risk of surgery complications and improving postoperative recovery. In this chapter, comprehensive descriptions of chemically and physically cross-linked hydrogels that can be used as injectable scaffolds for dental and craniofacial application are presented. Nanocomposite hydrogels, in which nano-sized particles may serve as reinforcing agents and impart functionality to the hydrogels, are also discussed. Special attention is given to peptide amphiphiles which can self-assemble into supramolecular configuration mimicking the extracellular matrix (ECM) structure. Finally, injectable microspheres and different techniques of fabrication are discussed in this chapter.

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Vorheriges Kapitel Microfluidic Technologies Using Oral Factors: Saliva-Based Studies
Nächstes Kapitel Animal Models in Dental Research
Literatur
1.
O’Brien, F. J. (2011). Biomaterials & scaffolds for tissue engineering. Materials Today, 14, 88–95.CrossRef
2.
Guyot, C., & Lerouge, S. (2018). Can we achieve the perfect injectable scaffold for cell therapy? Future Science OA, 4, FSO284.CrossRef
3.
Hou, Q., De Bank, P. A., & Shakesheff, K. M. (2004). Injectable scaffolds for tissue regeneration. ChemInform, Journal of Materials Chemistry, 14, 1915–1923.
4.
Kretlow, J. D., Klouda, L., & Mikos, A. G. (2007). Injectable matrices and scaffolds for drug delivery in tissue engineering. Advanced Drug Delivery Reviews, 59, 263–273.CrossRef
5.
Chang, B., Ahuja, N., Ma, C., & Liu, X. (2017). Injectable scaffolds: Preparation and application in dental and craniofacial regeneration. Materials Science & Engineering R: Reports, 111, 1–26.CrossRef
6.
Drury, J. L., & Mooney, D. J. (2003). Hydrogels for tissue engineering: Scaffold design variables and applications. Biomaterials, 24, 4337–4351.CrossRef
7.
Taylor, P. M. (2007). Biological matrices and bionanotechnology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 362, 1313–1320.CrossRef
8.
Langer, R., & Tirrell, D. A. (2004). Designing materials for biology and medicine. Nature, 428, 487–492.CrossRef
9.
Ratner, B. D., Hoffman, A. S., Schoen, F. J., & Lemons, J. E. (2012). Biomaterials science: An introduction to materials in medicine. Amsterdam: Academic Press.
10.
Silva, S. S., Mano, J. F., & Reis, R. L. (2010). Potential applications of natural origin polymer-based systems in soft tissue regeneration. Critical Reviews in Biotechnology, 30, 200–221.CrossRef
11.
Tan, H., Wan, L., Wu, J., & Gao, C. (2008). Microscale control over collagen gradient on poly(L-lactide) membrane surface for manipulating chondrocyte distribution. Colloids and Surfaces. B, Biointerfaces, 67, 210–215.CrossRef
12.
Guarino, V., Gloria, A., De Santis, R., & Ambrosio, L. (2010). Composite hydrogels for scaffold design, tissue engineering, and prostheses. In Biomedical applications of hydrogels handbook (pp. 227–245). New York: Springer.CrossRef
13.
Mueller, S. M., et al. (1999). Meniscus cells seeded in type I and type II collagen-GAG matrices in vitro. Biomaterials, 20, 701–709.CrossRef
14.
Tan, H., Huang, D., Lao, L., & Gao, C. (2009). RGD modified PLGA/gelatin microspheres as microcarriers for chondrocyte delivery. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 91, 228–238.CrossRef
15.
Sumita, Y., et al. (2006). Performance of collagen sponge as a 3-D scaffold for tooth-tissue engineering. Biomaterials, 27, 3238–3248.CrossRef
16.
Zhang, W., et al. (2006). The performance of human dental pulp stem cells on different three-dimensional scaffold materials. Biomaterials, 27, 5658–5668.CrossRef
17.
Khor, E. (2010). Medical applications of chitin and chitosan. In Chitin, chitosan, oligosaccharides and their derivatives (pp. 405–413). Boca Raton: CRC Press.CrossRef
18.
Qasim, S., et al. (2018). Electrospinning of chitosan-based solutions for tissue engineering and regenerative medicine. International Journal of Molecular Sciences, 19, 407.CrossRef
19.
Hao, T., et al. (2010). The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels. Osteoarthritis and Cartilage, 18, 257–265.CrossRef
20.
Tan, H., Chu, C. R., Payne, K. A., & Marra, K. G. (2009). Injectable in situ forming biodegradable chitosan-hyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials, 30, 2499–2506.CrossRef
21.
Zhang, Y., et al. (2006). Novel chitosan/collagen scaffold containing transforming growth factor-β1 DNA for periodontal tissue engineering. Biochemical and Biophysical Research Communications, 344, 362–369.CrossRef
22.
Kogan, G., Soltés, L., Stern, R., & Gemeiner, P. (2007). Hyaluronic acid: A natural biopolymer with a broad range of biomedical and industrial applications. Biotechnology Letters, 29, 17–25.CrossRef
23.
Fraser, J. R. E., & Laurent, T. C. (2007). Turnover and metabolism of hyaluronan. In Novartis Foundation Symposia (pp. 41–59). Chichester: Wiley.
24.
Inuyama, Y., et al. (2010). Effects of hyaluronic acid sponge as a scaffold on odontoblastic cell line and amputated dental pulp. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 92B, 120–128.CrossRef
25.
Chang, C.-H., et al. (2006). Tissue engineering-based cartilage repair with allogenous chondrocytes and gelatin-chondroitin-hyaluronan tri-copolymer scaffold: A porcine model assessed at 18, 24, and 36 weeks. Biomaterials, 27, 1876–1888.CrossRef
26.
Seal, B. (2001). Polymeric biomaterials for tissue and organ regeneration. Materials Science & Engineering R: Reports, 34, 147–230.CrossRef
27.
Sun, J., & Tan, H. (2013). Alginate-based biomaterials for regenerative medicine applications. Materials, 6, 1285–1309.CrossRef
28.
Boontheekul, T., Kong, H.-J., & Mooney, D. J. (2005). Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials, 26, 2455–2465.CrossRef
29.
Kang, E., et al. (2012). Microfluidic spinning of flat alginate fibers with grooves for cell-aligning scaffolds. Advanced Materials, 24, 4271–4277.CrossRef
30.
Kumabe, S., et al. (2006). Human dental pulp cell culture and cell transplantation with an alginate scaffold. Okajimas Folia Anatomica Japonica, 82, 147–155.CrossRef
31.
Fujiwara, S., Kumabe, S., & Iwai, Y. (2006). Isolated rat dental pulp cell culture and transplantation with an alginate scaffold. Okajimas Folia Anatomica Japonica, 83, 15–24.CrossRef
32.
Nguyen, M. K., & Lee, D. S. (2010). Injectable biodegradable hydrogels. Macromolecular Bioscience, 10, 563–579.CrossRef
33.
Li, Y., Rodrigues, J., & Tomás, H. (2012). Injectable and biodegradable hydrogels: Gelation, biodegradation and biomedical applications. Chemical Society Reviews, 41, 2193–2221.CrossRef
34.
Yu, L., & Ding, J. (2008). Injectable hydrogels as unique biomedical materials. Chemical Society Reviews, 37, 1473–1481.CrossRef
35.
Bidarra, S. J., Barrias, C. C., & Granja, P. L. (2014). Injectable alginate hydrogels for cell delivery in tissue engineering. Acta Biomaterialia, 10, 1646–1662.CrossRef
36.
Yang, J.-A., Yeom, J., Hwang, B. W., Hoffman, A. S., & Hahn, S. K. (2014). In situ-forming injectable hydrogels for regenerative medicine. Progress in Polymer Science, 39, 1973–1986.CrossRef
37.
Caló, E., & Khutoryanskiy, V. V. (2015). Biomedical applications of hydrogels: A review of patents and commercial products. European Polymer Journal, 65, 252–267.CrossRef
38.
Nguyen, K. T., & West, J. L. (2002). Photopolymerizable hydrogels for tissue engineering applications. Biomaterials, 23, 4307–4314.CrossRef
39.
Nguyen, Q. V., Huynh, D. P., Park, J. H., & Lee, D. S. (2015). Injectable polymeric hydrogels for the delivery of therapeutic agents: A review. European Polymer Journal, 72, 602–619.CrossRef
40.
Nicodemus, G. D., Villanueva, I., & Bryant, S. J. (2007). Mechanical stimulation of TMJ condylar chondrocytes encapsulated in PEG hydrogels. Journal of Biomedical Materials Research. Part A, 83, 323–331.CrossRef
41.
Davis, K. A., Burdick, J. A., & Anseth, K. S. (2003). Photoinitiated crosslinked degradable copolymer networks for tissue engineering applications. Biomaterials, 24, 2485–2495.CrossRef
42.
Thirumurugan, P., Matosiuk, D., & Jozwiak, K. (2013). Click chemistry for drug development and diverse chemical–biology applications. Chemical Reviews, 113, 4905–4979.CrossRef
43.
Kolb, H. C., Finn, M. G., & Sharpless, K. B. (2001). Click chemistry: Diverse chemical function from a few good reactions. Angewandte Chemie (International Ed. in English), 40, 2004–2021.CrossRef
44.
Nandivada, H., Jiang, X., & Lahann, J. (2007). Click chemistry: Versatility and control in the hands of materials scientists. Advanced Materials, 19, 2197–2208.CrossRef
45.
Park, S. H., et al. (2017). BMP2-modified injectable hydrogel for osteogenic differentiation of human periodontal ligament stem cells. Scientific Reports, 7, 6603.CrossRef
46.
Mather, B. D., Viswanathan, K., Miller, K. M., & Long, T. E. (2006). Michael addition reactions in macromolecular design for emerging technologies. Progress in Polymer Science, 31, 487–531.CrossRef
47.
Li, R., et al. (2017). Synthesis of in-situ formable hydrogels with collagen and hyaluronan through facile Michael addition. Materials Science & Engineering. C, Materials for Biological Applications, 77, 1035–1043.CrossRef
48.
Liu, M., et al. (2017). Injectable hydrogels for cartilage and bone tissue engineering. Bone Research, 5, 17014.CrossRef
49.
Teixeira, L. S. M., Feijen, J., van Blitterswijk, C. A., Dijkstra, P. J., & Karperien, M. (2012). Enzyme-catalyzed crosslinkable hydrogels: Emerging strategies for tissue engineering. Biomaterials, 33, 1281–1290.CrossRef
50.
Sperinde, J. J., & Griffith, L. G. (2000). Control and prediction of gelation kinetics in enzymatically cross-linked poly(ethylene glycol) hydrogels. Macromolecules, 33, 5476–5480.CrossRef
51.
Parhi, R. (2017). Cross-linked hydrogel for pharmaceutical applications: A review. Advanced Pharmaceutical Bulletin, 7, 515–530.CrossRef
52.
Xin, Y., & Yuan, J. (2012). Schiff’s base as a stimuli-responsive linker in polymer chemistry. Polymer Chemistry, 3, 3045–3055.CrossRef
53.
Hoffmann, B., et al. (2009). Characterisation of a new bioadhesive system based on polysaccharides with the potential to be used as bone glue. Journal of Materials Science. Materials in Medicine, 20, 2001–2009.CrossRef
54.
Wu, Y., et al. (2017). A soft tissue adhesive based on aldehyde-sodium alginate and amino-carboxymethyl chitosan preparation through the Schiff reaction. Frontiers of Materials Science, 11, 215–222.CrossRef
55.
Klouda, L. (2015). Thermoresponsive hydrogels in biomedical applications: A seven-year update. European Journal of Pharmaceutics and Biopharmaceutics, 97, 338–349.CrossRef
56.
Boustta, M., Colombo, P.-E., Lenglet, S., Poujol, S., & Vert, M. (2014). Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery. Journal of Controlled Release, 174, 1–6.CrossRef
57.
Haq, M. A., Su, Y., & Wang, D. (2017). Mechanical properties of PNIPAM based hydrogels: A review. Materials Science & Engineering. C, Materials for Biological Applications, 70, 842–855.CrossRef
58.
Jain, K., Vedarajan, R., Watanabe, M., Ishikiriyama, M., & Matsumi, N. (2015). Tunable LCST behavior of poly (N-isopropylacrylamide/ionic liquid) copolymers. Polymer Chemistry, 6, 6819–6825.CrossRef
59.
Xie, J., Li, A., & Li, J. (2017). Advances in pH-sensitive polymers for smart insulin delivery. Macromolecular Rapid Communications, 38, 1700413.MathSciNetCrossRef
60.
Rizwan, M., et al. (2017). pH sensitive hydrogels in drug delivery: Brief history, properties, swelling, and release mechanism, material selection and applications. Polymers, 9, 137.CrossRef
61.
Liu, Y.-Y., et al. (2006). pH-responsive amphiphilic hydrogel networks with IPN structure: A strategy for controlled drug release. International Journal of Pharmaceutics, 308, 205–209.CrossRef
62.
Wang, K., Fu, Q., Chen, X., Gao, Y., & Dong, K. (2012). Preparation and characterization of pH-sensitive hydrogel for drug delivery system. RSC Advances, 2, 7772–7780.CrossRef
63.
Draget, K. I., Skjåk-Braek, G., & Smidsrød, O. (1997). Alginate based new materials. International Journal of Biological Macromolecules, 21, 47–55.CrossRef
64.
Russo, R., Malinconico, M., & Santagata, G. (2007). Effect of cross-linking with calcium ions on the physical properties of alginate films. Biomacromolecules, 8, 3193–3197.CrossRef
65.
Donati, I., Asaro, F., & Paoletti, S. (2009). Experimental evidence of counterion affinity in alginates: The case of nongelling ion Mg2+. The Journal of Physical Chemistry. B, 113, 12877–12886.CrossRef
66.
Sun, J.-Y., et al. (2012). Highly stretchable and tough hydrogels. Nature, 489, 133–136.CrossRef
67.
Wang, M. S., Childs, R. F., & Chang, P. L. (2005). A novel method to enhance the stability of alginate-poly-L-lysine-alginate microcapsules. Journal of Biomaterials Science. Polymer Edition, 16, 91–113.
68.
Song, F., Li, X., Wang, Q., Liao, L., & Zhang, C. (2015). Nanocomposite hydrogels and their applications in drug delivery and tissue engineering. Journal of Biomedical Nanotechnology, 11, 40–52.CrossRef
69.
Gaharwar, A. K., Peppas, N. A., & Khademhosseini, A. (2014). Nanocomposite hydrogels for biomedical applications. Biotechnology and Bioengineering, 111, 441–453.CrossRef
70.
Nejadnik, M. R., et al. (2014). Self-healing hybrid nanocomposites consisting of bisphosphonated hyaluronan and calcium phosphate nanoparticles. Biomaterials, 35, 6918–6929.CrossRef
71.
Martínez-Sanz, E., et al. (2012). Minimally invasive mandibular bone augmentation using injectable hydrogels. Journal of Tissue Engineering and Regenerative Medicine, 6, s15–s23.CrossRef
72.
Gaharwar, A. K., Rivera, C. P., Wu, C.-J., & Schmidt, G. (2011). Transparent, elastomeric and tough hydrogels from poly(ethylene glycol) and silicate nanoparticles. Acta Biomaterialia, 7, 4139–4148.CrossRef
73.
Dvir, T., Timko, B. P., Kohane, D. S., & Langer, R. (2011). Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology, 6, 13–22.CrossRef
74.
Thomas, D., Gaspar, D., & Sorushanova, A. (2016). Scaffold and scaffold-free self-assembled systems in regenerative medicine. Biotechnology, 113, 1155–1163.
75.
Matson, J. B., & Stupp, S. I. (2012). Self-assembling peptide scaffolds for regenerative medicine. Chemical Communications, 48, 26–33.CrossRef
76.
Rosa, V., Zhang, Z., Grande, R. H. M., & Nör, J. E. (2013). Dental pulp tissue engineering in full-length human root canals. Journal of Dental Research, 92, 970–975.CrossRef
77.
Cavalcanti, B. N., Zeitlin, B. D., & Nör, J. E. (2013). A hydrogel scaffold that maintains viability and supports differentiation of dental pulp stem cells. Dental Materials, 29, 97–102.CrossRef
78.
Galler, K. M., et al. (2008). Self-assembling peptide amphiphile nanofibers as a scaffold for dental stem cells. Tissue Engineering. Part A, 14, 2051–2058.CrossRef
79.
Gupta, V., Khan, Y., Berkland, C. J., Laurencin, C. T., & Detamore, M. S. (2017). Microsphere-based scaffolds in regenerative engineering. Annual Review of Biomedical Engineering, 19, 135–161.CrossRef
80.
Hossain, K., Patel, U., & Ahmed, I. (2015). Development of microspheres for biomedical applications: A review. Progress in Biomaterials, 4, 1–19.CrossRef
81.
Leong, W., & Wang, D. A. (2015). Cell-laden polymeric microspheres for biomedical applications. Trends in Biotechnology, 33, 653–666.CrossRef
82.
Wang, H., Leeuwenburgh, S., & Li, Y. (2011). The use of micro-and nanospheres as functional components for bone tissue regeneration. Engineering Part B: Reviews, 18, 24–39.CrossRef
83.
Hernández, R. M., Orive, G., Murua, A., & Pedraz, J. L. (2010). Microcapsules and microcarriers for in situ cell delivery. Advanced Drug Delivery Reviews, 62, 711–730.CrossRef
84.
Rokstad, A., Lacík, I., de Vos, P., & Strand, B. L. (2014). Advances in biocompatibility and physico-chemical characterization of microspheres for cell encapsulation. Advanced Drug Delivery Reviews, 67, 111–130.CrossRef
85.
Tang, G., et al. (2012). Preparation of PLGA scaffolds with graded pores by using a gelatin-microsphere template as Porogen. Journal of Biomaterials Science. Polymer Edition, 23, 2241–2257.
86.
Matsuno, T., Hashimoto, Y., Adachi, S., & Omata, K. (2008). Preparation of injectable 3D-formed β-tricalcium phosphate bead/alginate composite for bone tissue engineering. Dental Materials, 27, 827–834.CrossRef
87.
Huang, W., Li, X., Shi, X., & Lai, C. (2014). Microsphere based scaffolds for bone regenerative applications. Biomaterials Science, 2, 1145.CrossRef
88.
Zhang, Z., Eyster, T. W., & Ma, P. X. (2016). Nanostructured injectable cell microcarriers for tissue regeneration. Nanomedicine, 11, 1611–1628.CrossRef
89.
McGinity, J. W., & O’Donnell, P. B. (1997). Preparation of microspheres by the solvent evaporation technique. Advanced Drug Delivery Reviews, 28, 25–42.CrossRef
90.
Nava-Arzaluz, M. G., Piñón-Segundo, E., Ganem-Rondero, A., & Lechuga-Ballesteros, D. (2012). Single emulsion-solvent evaporation technique and modifications for the preparation of pharmaceutical polymeric nanoparticles. Recent Patents on Drug Delivery & Formulation, 6, 209–223.CrossRef
91.
Xia, Y., & Pack, D. W. (2015). Uniform biodegradable microparticle systems for controlled release. Chemical Engineering Science, 125, 129–143.CrossRef
92.
Berkland, C., King, M., Cox, A., Kim, K., & Pack, D. W. (2002). Precise control of PLG microsphere size provides enhanced control of drug release rate. Journal of Controlled Release, 82, 137–147.CrossRef
93.
Paudel, A., Worku, Z. A., Meeus, J., Guns, S., & Van den Mooter, G. (2013). Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations. International Journal of Pharmaceutics, 453, 253–284.CrossRef
94.
Cal, K., & Sollohub, K. (2010). Spray drying technique. I: Hardware and process parameters. Journal of Pharmaceutical Sciences, 99, 575–586.CrossRef
95.
Blaker, J. J., Knowles, J. C., & Day, R. M. (2008). Novel fabrication techniques to produce microspheres by thermally induced phase separation for tissue engineering and drug delivery. Acta Biomaterialia, 4, 264–272.CrossRef
96.
Feng, W., et al. (2015). Synthesis and characterization of nanofibrous hollow microspheres with tunable size and morphology via thermally induced phase separation technique. RSC Advances, 5, 61580–61585.CrossRef
97.
Liu, X., Jin, X., & Ma, P. X. (2011). Nanofibrous hollow microspheres self-assembled from star-shaped polymers as injectable cell carriers for knee repair. Nature Materials, 10, 398–406.CrossRef
98.
Kuang, R., et al. (2016). Nanofibrous spongy microspheres for the delivery of hypoxia-primed human dental pulp stem cells to regenerate vascularized dental pulp. Acta Biomaterialia, 33, 225–234.CrossRef
Metadaten
Titel
Injectable Gels for Dental and Craniofacial Applications
verfasst von
Mohamed S. Ibrahim
Noha A. El-Wassefy
Dina S. Farahat
Copyright-Jahr
2020
Buch
Applications of Biomedical Engineering in Dentistry

Print ISBN: 978-3-030-21582-8

Electronic ISBN: 978-3-030-21583-5

Copyright-Jahr: 2020

DOI
https://doi.org/10.1007/978-3-030-21583-5_17

Neuer Inhalt

    Bildnachweise