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Erschienen in: Journal of Materials Science 23/2021

16.05.2021 | Polymers & biopolymers

Injectable hydrogels with two different rates of drug release based on pluronic/water system filled with poly(ε-caprolactone) microcapsules

verfasst von: Beatriz Delgado, Henrique Carrêlo, Mónica V. Loureiro, Ana C. Marques, João Paulo Borges, Maria Teresa Cidade

Erschienen in: Journal of Materials Science | Ausgabe 23/2021

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Abstract

The present paper regards the preparation and characterization of Pluronic F127 + F68/water/poly (ε-caprolactone) microcapsules (MCs) composite systems for tissue repair. The first part of the work relates to the production of poly(ε-caprolactone) (PCL) MCs via water-in-oil-in-water (W/O/W) double emulsion system combined with solvent evaporation method. The study of different process parameters in the final MCs characteristics and their drug release profile is herein reported. Different percentages of PCL, emulsion stabilizer, and volume proportions of the emulsion constituents have been tested, leading to considerable differences in the MCs size distributions. The selected MCs, containing an aqueous solution of methylene blue (MB) as a model drug, were then used to fill a Pluronic F127 + F68/water system leading to the final composite system (5 and 10 wt % MB loaded PCL MCs). The composite systems were characterised in the second part of the work in terms of its rheological behaviour and drug release performance. They were found to gellify at 30 °C, and present an extended drug release to a total of 18 days. The models that best define the release profiles were also studied, with the release of MB occurring mostly by Fick diffusion and polymer chain relaxation. Pluronic F127 + F68/water/poly (ε-caprolactone) MCs composite system is shown to be a promising injectable system, with two different drug release rates, for tissue repair.
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Metadaten
Titel
Injectable hydrogels with two different rates of drug release based on pluronic/water system filled with poly(ε-caprolactone) microcapsules
verfasst von
Beatriz Delgado
Henrique Carrêlo
Mónica V. Loureiro
Ana C. Marques
João Paulo Borges
Maria Teresa Cidade
Publikationsdatum
16.05.2021
Verlag
Springer US
Erschienen in
Journal of Materials Science / Ausgabe 23/2021
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-021-06156-x

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