Interaction of Analgesic Capsaicin Analogs with Substance P Receptors

NE-19550 is an orally active capsaicin analog whose analgesic and anti-inflammatory actions were recently described[1]. Recent studies have shown that the analgesic properties of this compound are not opioid in character, despite its good efficacy in the rodent hot-plate and tail flick assays for antinociception[2]. Further, it has been established that the anti-inflammatory analgesic activity displayed by NE-19550 in the carrageenan rat paw edema assay and other tests does not involve NSAID-like inhibition of prostanoid synthesis[3].