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Erschienen in:
Tissue Engineering for Cardiac Regeneration Kapitel lesen Erstes Kapitel lesen

2011 | OriginalPaper | Buchkapitel

Intramyocardial Stem Cell Transplantation Without Tissue Engineered Constructs: The Current Clinical Situation

verfasst von : Peter Donndorf, Gustav Steinhoff

Erschienen in: Myocardial Tissue Engineering

Verlag: Springer Berlin Heidelberg

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Abstract

After promising preclinical results, the surgical treatment of chronic ischemic heart disease patients with bone marrow stem cells has been successfully introduced within the last decade in the context of clinical studies and therapy trials. Combining intramyocardial bone marrow stem cell injection with established revascularisation procedures such as bypass surgery seems to offer additional functional benefits compared to standard therapy strategies alone. However, although the safety of intramyocardial stem cell therapy could be demonstrated, the clinical evidence obtained so far is heterogeneous and completion of ongoing Phase III trails is mandatory for conclusive evaluation regarding functional advantages offered by this new therapeutic tool in the cardiac surgeon’s hand. Besides ischemic heart disease also other pathologies—e.g. non-ischemic cardiomyopathy—might form indications for cardiac stem cell therapy, yet further clinical as well as preclinical evidence need to be obtained before adequate therapy strategies might be designed. Delivery and retention of adult stem cells remain limiting factors for treatment.

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Vorheriges Kapitel Creating Unique Cell Microenvironments for the Engineering of a Functional Cardiac Patch
Nächstes Kapitel Tissue Engineered Myocardium
Literatur
1.
Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., et al.: Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. U S A 98(18), 10344–10349 (2001)CrossRef
2.
Kajstura, J., Rota, M., Whang, B., Cascapera, S., Hosoda, T., Bearzi, C., et al.: Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ. Res. 96(1), 127–137 (2005)CrossRef
3.
Strauer, B.E., Brehm, M., Zeus, T., Kostering, M., Hernandez, A., Sorg, R.V., et al.: Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106(15), 1913–1918 (2002)CrossRef
4.
Stamm, C., Kleine, H.D., Choi, Y.H., Dunkelmann, S., Lauffs, J.A., Lorenzen, B., et al.: Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J. Thorac. Cardiovasc. Surg. 133(3), 717–725 (2007)CrossRef
5.
Allgöwer, M.: The Cellular Basis of Wound Repair. Charles C. Thomas, Springfield (1956)
6.
Krause, D.S., Theise, N.D., Collector, M.I., Henegariu, O., Hwang, S., Gardner, R., et al.: Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105(3), 369–377 (2001)CrossRef
7.
Jiang, Y., Jahagirdar, B.N., Reinhardt, R.L., Schwartz, R.E., Keene, C.D., Ortiz-Gonzalez, X.R., et al.: Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418(6893), 41–49 (2002)CrossRef
8.
Quaini, F., Urbanek, K., Graiani, G., Lagrasta, C., Maestri, R., Monica, M., et al.: The regenerative potential of the human heart. Int. J. Cardiol. 95(Suppl 1), S26–S28 (2004)CrossRef
9.
Goodell, M.A., Jackson, K.A., Majka, S.M., Mi, T., Wang, H., Pocius, J., et al.: Stem cell plasticity in muscle and bone marrow. Ann. N. Y. Acad. Sci. 938, 208–218 (2001). Discussion 18–20CrossRef
10.
Pfeffer, M.A., Braunwald, E.: Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 81(4), 1161–1172 (1990)CrossRef
11.
Ren, G., Michael, L.H., Entman, M.L., Frangogiannis, N.G.: Morphological characteristics of the microvasculature in healing myocardial infarcts. J. Histochem. Cytochem. 50(1), 71–79 (2002)CrossRef
12.
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S.M., Li, B., et al.: Bone marrow cells regenerate infarcted myocardium. Nature 410(6829), 701–705 (2001)CrossRef
13.
Murry, C.E., Soonpaa, M.H., Reinecke, H., Nakajima, H., Nakajima, H.O., Rubart, M., et al.: Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428(6983), 664–668 (2004)CrossRef
14.
Segers, V.F., Lee, R.T.: Stem-cell therapy for cardiac disease. Nature 451(7181), 937–942 (2008)CrossRef
15.
Stamm, C., Westphal, B., Kleine, H.D., Petzsch, M., Kittner, C., Klinge, H., et al.: Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361(9351), 45–46 (2003)CrossRef
16.
Bergmann, O., Bhardwaj, R.D., Bernard, S., Zdunek, S., Barnabe-Heider, F., Walsh, S., et al.: Evidence for cardiomyocyte renewal in humans. Science (New York, NY) 324(5923), 98–102 (2009)CrossRef
17.
Buckingham, M., Montarras, D.: Skeletal muscle stem cells. Curr. Opin. Genet. Dev. 18(4), 330–336 (2008)CrossRef
18.
Arsic, N., Mamaeva, D., Lamb, N.J., Fernandez, A.: Muscle-derived stem cells isolated as non-adherent population give rise to cardiac, skeletal muscle and neural lineages. Exp. Cell Res. 314(6), 1266–1280 (2008)CrossRef
19.
Pagani, F.D., DerSimonian, H., Zawadzka, A., Wetzel, K., Edge, A.S., Jacoby, D.B., et al.: Autologous skeletal myoblasts transplanted to ischemia-damaged myocardium in humans. Histological analysis of cell survival and differentiation. J. Am. Coll. Cardiol. 41(5), 879–888 (2003)CrossRef
20.
Leobon, B., Garcin, I., Menasche, P., Vilquin, J.T., Audinat, E., Charpak, S.: Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host. Proc. Natl. Acad. Sci. U S A 100(13), 7808–7811 (2003)CrossRef
21.
Reinecke, H., Poppa, V., Murry, C.E.: Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting. J. Mol. Cell. Cardiol. 34(2), 241–249 (2002)CrossRef
22.
Menasche, P., Hagege, A.A., Vilquin, J.T., Desnos, M., Abergel, E., Pouzet, B., et al.: Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J. Am. Coll. Cardiol. 41(7), 1078–1083 (2003)CrossRef
23.
Herreros, J., Prosper, F., Perez, A., Gavira, J.J., Garcia-Velloso, M.J., Barba, J., et al.: Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction. Eur. Heart J. 24(22), 2012–2020 (2003)CrossRef
24.
Fouts, K., Fernandes, B., Mal, N., Liu, J., Laurita, K.R.: Electrophysiological consequence of skeletal myoblast transplantation in normal and infarcted canine myocardium. Heart Rhythm 3(4), 452–461 (2006)CrossRef
25.
Itabashi, Y., Miyoshi, S., Yuasa, S., Fujita, J., Shimizu, T., Okano, T., et al.: Analysis of the electrophysiological properties and arrhythmias in directly contacted skeletal and cardiac muscle cell sheets. Cardiovasc. Res. 67(3), 561–570 (2005)CrossRef
26.
Menasche, P., Alfieri, O., Janssens, S., McKenna, W., Reichenspurner, H., Trinquart, L., et al.: The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117(9), 1189–1200 (2008)CrossRef
27.
Abraham, M.R., Henrikson, C.A., Tung, L., Chang, M.G., Aon, M., Xue, T., et al.: Antiarrhythmic engineering of skeletal myoblasts for cardiac transplantation. Circ. Res. 97(2), 159–167 (2005)CrossRef
28.
Yeh, E.T., Zhang, S., Wu, H.D., Korbling, M., Willerson, J.T., Estrov, Z.: Transdifferentiation of human peripheral blood CD34 + -enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 108(17), 2070–2073 (2003)CrossRef
29.
Bedada, F.B., Braun, T.: Partial induction of the myogenic program in noncommitted adult stem cells. Cells Tissues Organs 188(1–2), 189–201 (2008)CrossRef
30.
Koyanagi, M., Bushoven, P., Iwasaki, M., Urbich, C., Zeiher, A.M., Dimmeler, S.: Notch signaling contributes to the expression of cardiac markers in human circulating progenitor cells. Circ. Res. 101(11), 1139–1145 (2007)CrossRef
31.
Hock, H.: Some hematopoietic stem cells are more equal than others. J. Exp. Med. 207(6), 1127–1130 (2010)CrossRef
32.
Nygren, J.M., Jovinge, S., Breitbach, M., Sawen, P., Roll, W., Hescheler, J., et al.: Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat. Med. 10(5), 494–501 (2004)CrossRef
33.
Tse, H.F., Yiu, K.H., Lau, C.P.: Bone marrow stem cell therapy for myocardial angiogenesis. Curr. Vasc. Pharmacol. 5(2), 103–112 (2007)CrossRef
34.
Ma, N., Ladilov, Y., Kaminski, A., Piechaczek, C., Choi, Y.H., Li, W., et al.: Umbilical cord blood cell transplantation for myocardial regeneration. Transplant. Proc. 38(3), 771–773 (2006)CrossRef
35.
Schachinger, V., Erbs, S., Elsasser, A., Haberbosch, W., Hambrecht, R., Holschermann, H., et al.: Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur. Heart J. 27(23), 2775–2783 (2006)CrossRef
36.
Dobert, N., Britten, M., Assmus, B., Berner, U., Menzel, C., Lehmann, R., et al.: Transplantation of progenitor cells after reperfused acute myocardial infarction: evaluation of perfusion and myocardial viability with FDG-PET and thallium SPECT. Eur. J. Nucl. Med. Mol. Imaging 31(8), 1146–1151 (2004)CrossRef
37.
Alhadlaq, A., Mao, J.J.: Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 13(4), 436–448 (2004)CrossRef
38.
Makino, S., Fukuda, K., Miyoshi, S., Konishi, F., Kodama, H., Pan, J., et al.: Cardiomyocytes can be generated from marrow stromal cells in vitro. J. Clin. Invest. 103(5), 697–705 (1999)CrossRef
39.
Dai, W., Hale, S.L., Martin, B.J., Kuang, J.Q., Dow, J.S., Wold, L.E., et al.: Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 112(2), 214–223 (2005)CrossRef
40.
Amado, L.C., Saliaris, A.P., Schuleri, K.H., St John, M., Xie, J.S., Cattaneo, S., et al.: Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc. Natl. Acad. Sci. U S A 102(32), 11474–11479 (2005)CrossRef
41.
Yoon, Y.S., Park, J.S., Tkebuchava, T., Luedeman, C., Losordo, D.W.: Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction. Circulation 109(25), 3154–3157 (2004)CrossRef
42.
Kaminski, A., Steinhoff, G.: Current status of intramyocardial bone marrow stem cell transplantation. Semin. Thorac. Cardiovasc. Surg. 20(2), 119–125 (2008)CrossRef
43.
Patel, A.N., Geffner, L., Vina, R.F., Saslavsky, J., Urschel Jr., H.C., Kormos, R., et al.: Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized study. J. Thorac. Cardiovasc. Surg. 130(6), 1631–1638 (2005)CrossRef
44.
Pompilio, G., Steinhoff, G., Liebold, A., Pesce, M., Alamanni, F., Capogrossi, M.C., et al.: Direct minimally invasive intramyocardial injection of bone marrow-derived AC133+ stem cells in patients with refractory ischemia: preliminary results. Thorac. Cardiovasc. Surg. 56(2), 71–76 (2008)CrossRef
45.
Perin, E.C., Dohmann, H.F., Borojevic, R., Silva, S.A., Sousa, A.L., Mesquita, C.T., et al.: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107(18), 2294–2302 (2003)CrossRef
46.
Losordo, D.W., Schatz, R.A., White, C.J., Udelson, J.E., Veereshwarayya, V., Durgin, M., et al.: Intramyocardial transplantation of autologous CD34 + stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial. Circulation 115(25), 3165–3172 (2007)CrossRef
47.
Chachques, J.C.: Cellular cardiac regenerative therapy in which patients? Expert Rev. Cardiovasc. Ther. 7(8), 911–919 (2009)CrossRef
48.
Ohnishi, S., Yanagawa, B., Tanaka, K., Miyahara, Y., Obata, H., Kataoka, M., et al.: Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis. J. Mol. Cell. Cardiol. 42(1), 88–97 (2007)CrossRef
49.
Soeki, T., Tamura, Y., Shinohara, H., Tanaka, H., Bando, K., Fukuda, N.: Serial changes in serum VEGF and HGF in patients with acute myocardial infarction. Cardiology 93(3), 168–174 (2000)CrossRef
50.
Dhein, S., Garbade, J., Rouabah, D., Abraham, G., Ungemach, F.R., Schneider, K., et al.: Effects of autologous bone marrow stem cell transplantation. Journal of Cardiothoracic Surgery 1, 17 (2006)
51.
Seth, S., Narang, R., Bhargava, B., Ray, R., Mohanty, S., Gulati, G., et al.: Percutaneous intracoronary cellular cardiomyoplasty for nonischemic cardiomyopathy: clinical and histopathological results: the first-in-man ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) trial. J. Am. Coll. Cardiol. 48(11), 2350–2351 (2006)CrossRef
52.
Seth, S., Bhargava, B., Narang, R., Ray, R., Mohanty, S., Gulati, G., et al.: The ABCD (Autologous Bone Marrow Cells in Dilated Cardiomyopathy) trial a long-term follow-up study. J. Am. Coll. Cardiol. 55(15), 1643–1644 (2010)CrossRef
53.
Olgunturk, R., Kula, S., Sucak, G.T., Ozdogan, M.E., Erer, D., Saygili, A.: Peripheric stem cell transplantation in children with dilated cardiomyopathy: preliminary report of first two cases. Pediatric Transplantation 14(2), 257–260 (2009)CrossRef
54.
Zhang, N., Li, J., Luo, R., Jiang, J., Wang, J.A.: Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Exp. Clin. Endocrinol. Diabetes 116(2), 104–111 (2008)CrossRef
55.
Li, J.H., Zhang, N., Wang, J.A.: Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy. J. Endocrinol. Invest. 31(2), 103–110 (2008)MathSciNet
56.
Vilas-Boas, F., Feitosa, G.S., Soares, M.B., Mota, A., Pinho-Filho, J.A., Almeida, A.J., et al.: Early results of bone marrow cell transplantation to the myocardium of patients with heart failure due to Chagas disease. Arquivos brasileiros de cardiologia 87(2), 159–166 (2006)CrossRef
57.
Soares, M.B., Garcia, S., Campos de Carvalho, A.C., Ribeiro dos Santos, R.: Cellular therapy in Chagas’ disease: potential applications in patients with chronic cardiomyopathy. Regenerative Med. 2(3), 257–264 (2007)CrossRef
58.
Yelda, T., Berrin, U., Murat, S., Aytac, O., Sevgi, B., Yasemin, S., et al.: Intracoronary stem cell infusion in heart transplant candidates. Tohoku J. Exp. Med. 213(2), 113–120 (2007)CrossRef
59.
Miyagawa, S., Matsumiya, G., Funatsu, T., Yoshitatsu, M., Sekiya, N., Fukui, S., et al.: Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a case. Surg. Today 39(2), 133–136 (2009)CrossRef
60.
Zhao, Q., Sun, Y., Xia, L., Chen, A., Wang, Z.: Randomized study of mononuclear bone marrow cell transplantation in patients with coronary surgery. Ann. Thorac. Surg. 86(6), 1833–1840 (2008)CrossRef
61.
Hendrikx, M., Hensen, K., Clijsters, C., Jongen, H., Koninckx, R., Bijnens, E., et al.: Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial. Circulation 114(1 Suppl), I101–I107 (2006)
62.
Mocini, D., Staibano, M., Mele, L., Giannantoni, P., Menichella, G., Colivicchi, F., et al.: Autologous bone marrow mononuclear cell transplantation in patients undergoing coronary artery bypass grafting. Am. Heart J. 151(1), 192–197 (2006)CrossRef
63.
Ahmadi, H., Baharvand, H., Ashtiani, S.K., Soleimani, M., Sadeghian, H., Ardekani, J.M., et al.: Safety analysis and improved cardiac function following local autologous transplantation of CD133(+) enriched bone marrow cells after myocardial infarction. Curr. Neurovas. Res. 4(3), 153–160 (2007)CrossRef
64.
Klein, H.M., Ghodsizad, A., Marktanner, R., Poll, L., Voelkel, T., Mohammad Hasani, M.R., et al.: Intramyocardial implantation of CD133+ stem cells improved cardiac function without bypass surgery. Heart Surg. Forum 10(1), E66–E69 (2007)CrossRef
65.
Erbs, S., Linke, A., Adams, V., Lenk, K., Thiele, H., Diederich, K.W., et al.: Transplantation of blood-derived progenitor cells after recanalization of chronic coronary artery occlusion: first randomized and placebo-controlled study. Circ. Res. 97(8), 756–762 (2005)CrossRef
66.
Strauer, B.E., Brehm, M., Zeus, T., Bartsch, T., Schannwell, C., Antke, C., et al.: Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT Study. J. Am. Coll. Cardiol. 46(9), 1651–1658 (2005)CrossRef
67.
Shafy, A., Lavergne, T., Latremouille, C., Cortes-Morichetti, M., Carpentier, A., Chachques, J.C.: Association of electrostimulation with cell transplantation in ischemic heart disease. J. Thorac. Cardiovasc. Surg. 138(4), 994–1001 (2009)CrossRef
68.
Sodian, R., Schaefermeier, P., Abegg-Zips, S., Kuebler, W.M., Shakibaei, M., Daebritz, S., et al.: Use of human umbilical cord blood-derived progenitor cells for tissue-engineered heart valves. Ann. Thorac. Surg. 89(3), 819–828 (2010)CrossRef
Metadaten
Titel
Intramyocardial Stem Cell Transplantation Without Tissue Engineered Constructs: The Current Clinical Situation
verfasst von
Peter Donndorf
Gustav Steinhoff
Copyright-Jahr
2011
Verlag
Springer Berlin Heidelberg
Buch
Myocardial Tissue Engineering

Print ISBN: 978-3-642-18055-2

Electronic ISBN: 978-3-642-18056-9

Copyright-Jahr: 2011

DOI
https://doi.org/10.1007/8415_2010_45

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