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Erschienen in:
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2015 | OriginalPaper | Buchkapitel

1. Introduction

verfasst von : Yan Luo, Krishnendu Chakrabarty, Tsung-Yi Ho

Erschienen in: Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Verlag: Springer International Publishing

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Abstract

Microfluidic biochips have emerged as powerful and reliable toolkits for biotechnology applications, such as chemical synthesis, the diagnosis of diseases, and the development of new drugs [1–3]. Nanoliter and picoliter volumes of biological samples can be manipulated on microfluidic devices under software control. Compared to conventional devices and analyzers, microfluidic devices offer many unique advantages.

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Nächstes Kapitel Error-Recovery in Cyberphysical Biochips
Literatur
1.
R. Fair, “Digital microfluidics: is a true lab-on-a-chip possible?”, Microfluidic and Nanofluidic, vol. 3, pp. 245–281, 2007.CrossRef
2.
H. Becker, “Microfluidics: a technology coming of age”, Medical Device Technology, vol. 19, 2008.
3.
R. Fair, A. Khlystov, T. Tailor, V. Ivanov, R. Evans, P. Griffin, V. Srinivasan, V. Pamula, M. Pollack, and J. Zhou, “Chemical and biological applications of digital-microfluidic devices”, IEEE Design & Test of Computers, vol. 24, pp. 10–24, 2007.CrossRef
4.
F. Su, K. Chakrabarty and R. B. Fair, “Microfluidics-based biochips: technology issues, implementation platforms, and design automation challenges”, IEEE Transactions on Computer-Aided Design of Integrated Circuits & Systems, vol. 25, pp. 211–223, February 2006.CrossRef
5.
K. Chakrabarty, R. Fair and J. Zeng, “Design tools for digital microfluidic biochips: Towards functional diversification and more than Moore”, IEEE Trans. CAD, vol. 29, pp. 1001–1017, 2010.CrossRef
6.
H.-C. Chang, and L. Yeo, Electrokinetically Driven Microfluidics and Nanofluidics”, New York, NY: Cambridge University Press, 2009.
7.
8.
9.
P. Marcoux, M. Dupoy, R. Mathey, A. Novelli-Rousseau, V. Heran, S. Moralesa, F. Riveraa, P. Joly, J. Moy, and F. Mallard, “Micro-confinement of bacteria into w/o emulsion droplets for rapid detection and enumeration”, Colloids and surfaces A:Physicochemical and engineering aspects, vol. 377, no 1–3, pp. 54–62, 2011.CrossRef
10.
11.
B. Kirby, Micro- and Nanoscale Fluid Mechanics: Transport in Microfluidic Devices, New York, NY: Cambridge University Press, 2010.CrossRef
12.
R. Tadmor, “Line energy and the relation between advancing, receding and Young contact angles”, Langmuir, Volumne 20, Issue 18, pp. 7659–7664, 2004.
13.
P.-G. Gennes, F. Brochard-Wyart, and D. Quere, Capillary and Wetting Phenomena - Drops, Bubbles, Pearls, Waves, New York, NY: Springer Press, 2004.CrossRef
14.
D. Woodruff, The Chemical Physics of Solid Surfaces, Amsterdam, Netherlands: Elsevier, 2002.
15.
F. Saeki, J. Baum, H. Moon, J. Yoon, C.-J. Kim, and R. Garrell, Polym, “Electrowetting on dielectrics (EWOD): reducing voltage requirements for microfluidics mater”, Sci. Eng, Issue 85, pp. 12–13, 2001.
16.
J. Reed and K. Guthe, College Physics, Charleston, SC: Nabu Press, 2010
17.
M. Pollack, R. Fair, and A. Shenderov, “Electrowetting-based actuation of liquid droplets for microfluidic applications”, Appl. Phys Lett, vol. 77, pp. 1725–1727, 2000.CrossRef
18.
J. Lee, H. Moon J. Fowler, C.-J Kim and T. Schoellhammer, “Addressable micro liquid handling by electric control of surface tension”, Proc. of 2001 IEEE 14th International Conference on MEMS, pp. 499–502, 2001.
19.
S.-K. Cho et. al., “Towards digital microfluidic circuits: creating, transporting, cutting and merging liquid droplets by electrowetting-based actuation”, IEEE International Conference on Micro Electro Mechanical Systems, pp. 454–461, 2002.
20.
R. Fair, A. Khlystov, V. Srinivasan, V. Pamula, and K. Weaver, “Integrated chemical/biochemical sample collection, pre-concentration, and analysis on a digital microfluidic lab-on-a-chip platform”, Proceedings of SPIE, volume 5591, Issue 8, page 113–124, 2004.CrossRef
21.
22.
T. Xu and K. Chakrabarty, “Functional testing of digital microfluidic biochips”, Proc. IEEE International Test Conference, pp. 1–10, 2007.
23.
H. Ren, V. Srinivasan, and R. Fair, “Design and testing of an interpolating mixing architecture for electrowetting-based droplet-on-chip chemical dilution”, International Conference on Solid-State Sensors, Actuators and Microsystems, Volume 1, pp. 619–622, 2003.
24.
I. Nad, H. Yang, P. Park, and A. Wheeler, “Digital microfluidics for cell-based assays”, Lab Chip, Volume 8, Issue 4, pp. 519–526, 2008.CrossRef
25.
Y.-Y. Lin, R. Evans, E. Welch, B.-N. Hsu, A. Madison, and R. Fair, “Low voltage electrowetting-on-dielectric platform using multi-layer insulators”, Sensors and Actuators, B: Chemical, vol. 105, pp. 465–470, 2010.
26.
V. Pamula, P. Paik, J. Venkatraman, M. Pollack, and R. Fair, “Microfluidic electrowetting-based droplet mixing”, IEEE MEMS Conference Proceedings, pp. 8–10, 2001.
27.
P. Paik, V. Pamula, and R. Fair, “Rapid droplet mixers for digital microfluidic systems”, Lab on a Chip, vol. 3, pp. 253–259, 2003.CrossRef
28.
M. Pollack, Electrowetting-based Microactuation of Droplets for Digital Microfluidics, PhD Thesis, Duke University, Durham, NC, 2001.
29.
T.-Y. Ho, K. Chakrabarty and P. Pop, “Digital microfluidic biochips: Recent research and emerging challenges”, Proc. IEEE CODES+ISSS, 2011.
30.
J. Gao, X. Liu, T. Chen, P.-I. Mak, Y. Du, M. Vai, B. Lin, and R. Martins, “An intelligent digital microfluidic system with fuzzy enhanced feedback for multi-droplet manipulation”, Lab on a Chip, Issue 13, volume 13, 2013.
31.
H. Dutton, Understanding Optical Communications, Upper Saddle River, New Jersey: Prentice Hall Press, 1998.
32.
N. Jokerst, L. Luan, S. Palit, M. Royal, S. Dhar, M. Brooke, and T. Tyler II, “Progress in chip-scale photonic sensing”, IEEE Trans. Biomedical Circuits and Sys., vol. 3, pp. 202–211, 2009.CrossRef
33.
R. Evans et. al., “Optical detection heterogeneously integrated with a coplanar digital microfluidic lab-on-a-chip platform”, Proc. IEEE Sensors Conf., pp. 423–426, Oct. 2007.
34.
F. Su, S. Ozev and K. Chakrabarty, “Ensuring the operational health of droplet-based microelectrofluidic biosensor systems”, IEEE Sensors, vol. 5, pp. 763–773, August 2005.CrossRef
35.
K. Hu, B.-N. Hsu, A. Madison, K. Chakrabarty and R. Fair, “Fault detection, real-time error recovery, and experimental demonstration for digital microfluidic biochips”, Proc. IEEE/ACM Design, Automation and Test in Europe (DATE) Conference, pp. 559–564, 2013.
36.
D. Tommasini, “Dielectric insulation and high-voltage issues”, arXiv:1104.0802v1, 2011.
37.
K. Bohringer, “Modeling and controlling parallel tasks in droplet-based microfluidic systems”, IEEE Transactions on Computer-Aided Design of Integrated Circuits & Systems, vol. 2, pp. 329–339, 2006.
38.
P.-H. Yuh, C.-L. Yang, and Y.-W. Chang, “Placement of digital microfluidic biochips using the T-tree formulation”, Proc. IEEE/ACM Design Automation Conference, pp. 931–934, 2006.
39.
M. Cho and D. Z. Pan, “A high-performance droplet router for digital microfluidic biochips”, Proc. ACM International Symposium on Physical Design, pp. 1714–1724, 2008.
40.
T.-W. Huang, C.-H. Lin, and T.-Y. Ho, “A contamination aware droplet routing algorithm for the synthesis of digital microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 29, no. 11, pp. 1682–1695, 2010.CrossRef
41.
K. Chakrabarty and F. Su, Digital Microfluidic Biochips: Synthesis, Testing, and Reconfiguration Techniques, Boca Raton, FL: CRC Press, 2006.CrossRef
42.
T. Xu and K. Chakrabarty, “Integrated droplet routing in the synthesis of microfluidic biochips”, Proc. IEEE/ACM Design Automation Conference, pp. 948–953, 2007.
43.
T. Xu and K. Chakrabarty, “Broadcast electrode-addressing for pin-constrained multi-functional digital microfluidic biochips”, Proc. IEEE/ACM Design Automation Conference, pp. 173–178, 2008.
44.
Y. Zhao and K. Chakrabarty, “Simultaneous optimization of droplet routing and control-pin mapping to electrodes in digital microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 31, pp. 242–254, February 2012.CrossRef
45.
D. Grissom and P. Brisk, “Fast online synthesis of generally programmable digital microfluidic biochips”, Proc. CODES+ISSS, pp. 413–422, 2012.
46.
F. Su, S. Ozev, K. Chakrabarty, “Test planning and test resource optimization for droplet-based microfluidic systems”, Journal of Electronic Testing: Theory and Applications, Volume 22 Issue 2, pp. 199–210, April 2006.CrossRef
47.
D. Mitra, S. Ghoshal, H. Rahaman, K. Chakrabarty, and B. Bhattacharya, “On-line error detection in digital microfluidic biochips”, Proc. IEEE Asian Test Symposium, pp. 332–337, 2012.
48.
Y. Zhao, T. Xu, and K. Chakrabarty, “Integrated control-path design and error recovery in digital microfluidic lab-on-chip”, ACM JETC, Vol. 6, No. 3, Article 11, 2010.
49.
V. Srinivasan, V. Pamula, and R. Fair, “An integrated digital microfluidic lab-on-a-chip for clinical diagnostics on human physiological fluids”, Lab on a Chip, vol. 4, pp. 310–315, 2004.CrossRef
50.
Z. Xiao and E. Young, “CrossRouter: A droplet router for cross-referencing digital microfluidic biochips”, IEEE/ACM Asia South Pacific Design Automation Conference, pp. 269–274, 2010.
51.
C.-Y. Lin and Y.-W. Chang, “Cross-contamination aware design methodology for pin-constrained digital microfluidic biochips”, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, vol. 30, Issue 6, pp. 817–828, 2011.CrossRefMathSciNet
52.
S.-K. Fan, C. Hashi, C.-J. Kim, “Manipulation of multiple droplets on N × M grid by cross-reference EWOD driving scheme and pressure-contact packaging”, IEEE International Conference on Micro Electro Mechanical Systems, pp. 694–697, 2003.
53.
H.C. Yeung and F.Y. Young, “General purpose cross-referencing Microfluidic Biochip with reduced pin-count”, Asia and South Pacific Design Automation Conference, pp. 238–243, 2014.
54.
T. A. Dinh, S. Yamashita, and T.-Y. Ho, “A logic integrated optimal pin-count design for digital microfluidic biochips”, Proceedings of the conference on Design, Automation & Test in Europe, pp. 1–6, 2014.
55.
T.-W. Huang, J.-W. Chang, and T.-Y. Ho, “Integrated fluidic-chip co-design methodology for digital microfluidic biochips”, Proceedings of ACM International Symposium on Physical Design, pp. 49–56, 2012.
Metadaten
Titel
Introduction
verfasst von
Yan Luo
Krishnendu Chakrabarty
Tsung-Yi Ho
Copyright-Jahr
2015
Buch
Hardware/Software Co-Design and Optimization for Cyberphysical Integration in Digital Microfluidic Biochips

Print ISBN: 978-3-319-09005-4

Electronic ISBN: 978-3-319-09006-1

Copyright-Jahr: 2015

DOI
https://doi.org/10.1007/978-3-319-09006-1_1

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