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Erschienen in: Cognitive Neurodynamics 4/2020

04.05.2020 | Research Article

Ionic channel blockage in stochastic Hodgkin–Huxley neuronal model driven by multiple oscillatory signals

verfasst von: Xiuying Zhou, Ying Xu, Guowei Wang, Ya Jia

Erschienen in: Cognitive Neurodynamics | Ausgabe 4/2020

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Abstract

Ionic channel blockage and multiple oscillatory signals play an important role in the dynamical response of pulse sequences. The effects of ionic channel blockage and ionic channel noise on the discharge behaviors are studied in Hodgkin–Huxley neuronal model with multiple oscillatory signals. It is found that bifurcation points of spontaneous discharge are altered through tuning the amplitude of multiple oscillatory signals, and the discharge cycle is changed by increasing the frequency of multiple oscillatory signals. The effects of ionic channel blockage on neural discharge behaviors indicate that the neural excitability can be suppressed by the sodium channel blockage, however, the neural excitability can be reversed by the potassium channel blockage. There is an optimal blockage ratio of potassium channel at which the electrical activity is the most regular, while the order of neural spike is disrupted by the sodium channel blockage. In addition, the frequency of spike discharge is accelerated by increasing the ionic channel noise, the firing of neuron becomes more stable if the ionic channel noise is appropriately reduced. Our results might provide new insights into the effects of ionic channel blockages, multiple oscillatory signals, and ionic channel noises on neural discharge behaviors.

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Metadaten
Titel
Ionic channel blockage in stochastic Hodgkin–Huxley neuronal model driven by multiple oscillatory signals
verfasst von
Xiuying Zhou
Ying Xu
Guowei Wang
Ya Jia
Publikationsdatum
04.05.2020
Verlag
Springer Netherlands
Erschienen in
Cognitive Neurodynamics / Ausgabe 4/2020
Print ISSN: 1871-4080
Elektronische ISSN: 1871-4099
DOI
https://doi.org/10.1007/s11571-020-09593-7

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