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Erschienen in:
2014 | OriginalPaper | Buchkapitel
Joint Analysis of Functional and Phylogenetic Composition for Human Microbiome Data
verfasst von : Xingpeng Jiang, Xiaohua Hu, Weiwei Xu
Erschienen in: Bioinformatics Research and Applications
Verlag: Springer International Publishing
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With the advance of high-throughput sequencing technology, it is possible to investigate many complex biological and ecological systems. The objective of Human Microbiome Project (HMP) is to explore the microbial diversity in our human body and to provide experimental and computational standards for subsequent similar studies. The first-stage HMP generated a lot of data for computational analysis and provided a challenge for integration and interpretation of various microbiome data. In this paper, we introduce a data integration method –
L
aplacian-regularized
J
oint
N
on-negative
M
atrix
F
actorization (LJ-NMF) for analyzing functional and phylogenetic profiles from HMP jointly. The experimental results indicate that the proposed method offers an efficient framework for microbiome data analysis.