Abstract
Petrochemical plastics are nonbiodegradable synthetic organic polymers. It has various applications and become an essential part of our daily lives. However, the improper disposal of plastics results in the deaths of millions of animals annually and the reduction of soil fertility and also causes severe environmental pollution. The vast consumption and accumulation of plastics have become one of the major problems throughout the world. In response to these problems, there has been considerable interest in the development and production of biodegradable microbial bioplastics which can serve as a potential alternative to petrochemical plastics. Polyhydroxyalkanoates (PHAs) are microbial bioplastics that belong to a family of biopolyesters, primarily composed of R-3-hydroxyalkanoic acid monomers unit. Wide varieties of microorganisms have been reported to synthesize polyhydroxyalkanoate (PHA) and its copolymers as intracellular inclusion under carbon-rich and other nutritional limiting conditions. PHA and its copolymers have attracted researchers and industries because of their potential use as biodegradable and biocompatible thermoplastics. It has remarkable applications in the field of tissue engineering, drug delivery, pharmaceutical, and packaging industry. The development of microbial bioplastics and their products would help to maintain the sustainability of the environment and to reduce the emission of greenhouse gases. This chapter is focused on the updated information on microbial bioplastic (PHA) production and its progress in biotechnological and other industrial applications.
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References
Abdalkarim SY, Yu HY, Song ML et al (2017) In vitro degradation and possible hydrolytic mechanism of PHBV nanocomposites by incorporating cellulose nanocrystal-ZnO nanohybrids. Carbohydr Polym 176:38–49. https://doi.org/10.1016/j.carbpol.2017.08.051
Abdel-Rahman MA, Desouky SE, Azab MS et al (2017) Fermentative production of polyhydroxyalkanoates (PHAs) from glycerol by Zobellella taiwanensis Azu-IN1. J Appl Biol Biotechnol 5(05):16–25. https://doi.org/10.7324/JABB.2017.50503
Abe H, Doi Y, Fukushima T et al (1994) Biosynthesis from gluconate of a random copolyester consisting of 3-hydroxybutyrate and medium-chain-length 3-hydroxyalkanoates by Pseudomonas sp. 61-3. Int J Biol Macromol 16(3):115–119. https://doi.org/10.1016/0141-8130(94)90036-1
Ajmal AW, Masood F, Yasin T (2018) Influence of sepiolite on thermal, mechanical and biodegradation properties of poly-3-hydroxybutyrate-co-3-hydroxyvalerate nanocomposites. Appl Clay Sci 156:11–19. https://doi.org/10.1016/j.clay.2018.01.010
Al-Battashi HS, Annamalai N, Sivakumar N et al (2019) Lignocellulosic biomass (LCB): a potential alternative biorefinery feedstock for polyhydroxyalkanoates production. Rev Environ Sci Biotechnol 18(1):183–205. https://doi.org/10.1007/s11157-018-09488-4
de Almeida Neto GR, Barcelos MV, Ribeiro ME et al (2019) Formulation and characterization of a novel PHBV nanocomposite for bone defect filling and infection treatment. Mater Sci Eng C 104:110004. https://doi.org/10.1016/j.msec.2019.110004
Altun M (2019) Polyhydroxyalkanoate production using waste vegetable oil and filtered digestate liquor of chicken manure. Prep Biochem Biotechnol 49(5):493–500. https://doi.org/10.1080/10826068.2019.1587626
Amaro TM, Rosa D, Comi G et al (2019) Prospects for the use of whey for polyhydroxyalkanoate (PHA) production. Front Microbiol 10:992. https://doi.org/10.3389/fmicb.2019.00992
de Andrade CS, Nascimento VM, Cortez-Vega WR et al (2019) Exploiting cheese whey as co-substrate for polyhydroxyalkanoates synthesis from Burkholderia sacchari and as raw material for the development of biofilms. Waste Biomass Valoriz 10(6):1609–1616. https://doi.org/10.1007/s12649-017-0175-8
Andreeßen B, Lange AB, Robenek H et al (2010) Conversion of glycerol to poly (3-hydroxypropionate) in recombinant Escherichia coli. Appl Environ Microbiol 76(2):622–626. https://doi.org/10.1128/AEM.02097-09
Anjum A, Zuber M, Zia KM et al (2016) Microbial production of polyhydroxyalkanoates (PHAs) and its copolymers: a review of recent advancements. Int J Biol Macromol 89:161–174. https://doi.org/10.1016/j.ijbiomac.2016.04.069
Basumatary K, Daimary P, Das SK et al (2018) Lagerstroemia speciosa fruit-mediated synthesis of silver nanoparticles and its application as filler in agar-based nanocomposite films for antimicrobial food packaging. Food Packag 17:99–106. https://doi.org/10.1016/j.fpsl.2018.06.003
Benesova P, Kucera D, Marova I et al (2017) Chicken feather hydrolysate as inexpensive complex nitrogen source for PHA production by Cupriavidus necator on waste frying oils. Lett Appl Microbiol 65:182–188. https://doi.org/10.1111/lam.12762
Bertrand JL, Ramsay BA, Ramsay JA et al (1990) Biosynthesis of poly-β-hydroxyalkanoates from pentoses by Pseudomonas pseudoflava. Appl Environ Microbiol 56(10):3133–3138
Bhalla A, Bansal N, Kumar S et al (2013) Improved lignocellulose conversion to biofuels with thermophilic bacteria and thermostable enzymes. Bioresour Technol 128:751–759. https://doi.org/10.1016/j.biortech.2012.10.145
Bhatia SK, Shim YH, Jeon JM et al (2015) Starch based polyhydroxybutyrate production in engineered Escherichia coli. Bioprocess Biosyst Eng 38(8):1479–1484. https://doi.org/10.1007/s00449-015-1390-y
Bhatia SK, Yoon JJ, Kim HJ et al (2018) Engineering of artificial microbial consortia of Ralstonia eutropha and Bacillus subtilis for poly (3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production from sugarcane sugar without precursor feeding. Bioresour Technol 257:92–101. https://doi.org/10.1016/j.biortech.2018.02.056
Bhatia SK, Gurav R, Choi TR et al (2019a) Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) production from engineered Ralstonia eutropha using synthetic and anaerobically digested food waste derived volatile fatty acids. Int J Biol Macromol 133:1–10. https://doi.org/10.1016/j.ijbiomac.2019.04.083
Bhatia SK, Gurav R, Choi TR et al (2019b) Bioconversion of plant biomass hydrolysate into bioplastic (polyhydroxyalkanoates) using Ralstonia eutropha 5119. Bioresour Technol 271:306–315. https://doi.org/10.1016/j.biortech.2018.09.122
Bhatia SK, Wadhwa P, Hong JW et al (2019c) Lipase mediated functionalization of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) with ascorbic acid into an antioxidant active biomaterial. Int J Biol Macromol 123:117–123
Bhubalan K, Rathi DN, Abe H et al (2010) Improved synthesis of P (3HB-co-3HV-co-3HHx) terpolymers by mutant Cupriavidus necator using the PHA synthase gene of Chromobacterium sp. USM2 with high affinity towards 3HV. Polym Degrad Stab 95(8):1436–1442. https://doi.org/10.1016/j.polymdegradstab.2009.12.018
Bondeson D, Mathew A, Oksman K (2006) Optimization of the isolation of nanocrystals from microcrystalline cellulose by acid hydrolysis. Cellulose 13(2):171. https://doi.org/10.1007/s10570-006-9061-4
Braga NF, Vital DA, Guerrini LM et al (2018) PHBV-TiO2 mats prepared by electrospinning technique: physico-chemical properties and cytocompatibility. Biopolymers 109(5):e23120. https://doi.org/10.1002/bip.23120
Bugnicourt E, Cinelli P, Lazzeri A et al (2014) Polyhydroxyalkanoate (PHA): review of synthesis, characteristics, processing and potential applications in packaging. Express Polym Lett 8:791–808. http://hdl.handle.net/11336/4563
Bustamante D, Segarra S, Tortajada M et al (2019) In silico prospection of microorganisms to produce polyhydroxyalkanoate from whey: Caulobacter segnis DSM 29236 as a suitable industrial strain. Microb Biotechnol 12(3):487–501. https://doi.org/10.1111/1751-7915.13371
Chek MF, Kim SY, Mori T et al (2017) Structure of polyhydroxyalkanoate (PHA) synthase PhaC from Chromobacterium sp. USM2, producing biodegradable plastics. Sci Rep 7(1):1–5. https://doi.org/10.1038/s41598-017-05509-4
Chen GQ (2010) Plastics completely synthesized by bacteria: polyhydroxyalkanoates. In: Plastics from bacteria. Springer, Berlin, pp 17–37. https://doi.org/10.1007/978-3-642-03287-5_2
Chen CW, Don TM, Yen HF (2006) Enzymatic extruded starch as a carbon source for the production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) by Haloferax mediterranei. Process Biochem 41(11):2289–2296. https://doi.org/10.1016/j.procbio.2006.05.026
Chien C-C, Ho L-Y (2008) Polyhydroxyalkanoates production from carbohydrates by a genetic recombinant Aeromonas sp. Lett Appl Microbiol 47:587–593. https://doi.org/10.1111/j.1472-765X.2008.02471.x
Cho IJ, Choi KR, Lee SY (2020) Microbial production of fatty acids and derivative chemicals. Curr Opin Biotechnol 65:129–141. https://doi.org/10.1016/j.copbio.2020.02.006
Chohan SN, Copeland L (1998) Acetoacetyl coenzyme A reductase and polyhydroxybutyrate synthesis in Rhizobium (Cicer) sp. strain CC 1192. Appl Environ Microbiol 64:2859–2863. https://doi.org/10.1128/AEM.64.8.2859-2863.1998
Choi JI, Lee SY, Han K (1998) Cloning of the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes and use of these genes for enhanced production of poly (3-hydroxybutyrate) in Escherichia coli. Appl Environ Microbiol 64(12):4897–4903. https://doi.org/10.1128/AEM.64.12.4897-4903.1998
Choiniere P (2015) Development of polyhydroxyalkanoate nanoparticles for cancer therapy. https://surface.syr.edu/honors_capstone/908
Chun YS, Kim WN (2000) Thermal properties of poly (hydroxybutyrate-co-hydroxyvalerate) and poly (ϵ-caprolactone) blends. Polymer 41(6):2305–2308. https://doi.org/10.1016/S0032-3861(99)00534-0
Ciesielski S, Górniak D, Możejko J et al (2014) The diversity of bacteria isolated from Antarctic freshwater reservoirs possessing the ability to produce polyhydroxyalkanoates. Curr Microbiol 69:594–603. https://doi.org/10.1007/s00284-014-0629-1
Clifton-García B, González-Reynoso O, Robledo-Ortiz JR et al (2020) Forest soil bacteria able to produce homo and copolymers of polyhydroxyalkanoates from several pure and waste carbon sources. Lett Appl Microbiol 70(4):300–309. https://doi.org/10.1111/lam.13272
Colombo B, Calvo MV, Sciarria TP et al (2019) Biohydrogen and polyhydroxyalkanoates (PHA) as products of a two-steps bioprocess from deproteinized dairy wastes. Waste Manag 95:22–31. https://doi.org/10.1016/j.wasman.2019.05.052
Corrado I, Abdalrazeq M, Pezzella C et al (2020) Design and characterization of poly (3-hydroxybutyrate-co-hydroxyhexanoate) nanoparticles and their grafting in whey protein-based nanocomposites. Food Hydrocoll 15:106167. https://doi.org/10.1016/j.foodhyd.2020.106167
Dalal J, Lal B (2019) Microbial polyhydroxyalkanoates: current status and future prospects. In: High value fermentation products: human welfare II, vol 20. John Wiley & Sons Inc, New York, NY, pp 351–387
Das S, Majumder A, Shukla V, Suhazsini P et al (2018) Biosynthesis of poly (3-hydroxybutyrate) from cheese whey by Bacillus megaterium NCIM 5472. J Polym Environ 26(11):4176–4187. https://doi.org/10.1007/s10924-018-1288-2
David A, Govil T, Tripathi AK (2018) Thermophilic anaerobic digestion: enhanced and sustainable methane production from co-digestion of food and lignocellulosic wastes. Energies 11(8):2058. https://doi.org/10.3390/en11082058
Dennis D, Liebig C, Holley T et al (2003) Preliminary analysis of polyhydroxyalkanoate inclusions using atomic force microscopy. FEMS Microbiol Lett 226(1):113–119. https://doi.org/10.1016/S0378-1097(03)00610-4
Desuoky AM, El-Haleem ABD, Zaki SA et al (2007) Biosynthesis of polyhydroxyalkanoates in wild type yeasts. JASEM 11:3. https://doi.org/10.4314/jasem.v11i3.55066
Dietrich K, Dumont MJ, Del Rio LF et al (2019) Sustainable PHA production in integrated lignocellulose biorefineries. New Biotechnol 49:161–168. https://doi.org/10.1016/j.nbt.2018.11.004
Díez-Pascual AM, Diez-Vicente AL (2014) ZnO-reinforced poly (3-hydroxybutyrate-co-3-hydroxyvalerate) bionanocomposites with antimicrobial function for food packaging. ACS Appl Mater 6(12):9822–9834. https://doi.org/10.1021/am502261e
Din FU, Aman W, Ullah I et al (2017) Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. Int J Nanomedicine 12:7291. https://doi.org/10.2147/IJN.S146315
Favaro L, Basaglia M, Casella S (2019) Improving polyhydroxyalkanoate production from inexpensive carbon sources by genetic approaches: a review. Biofuels Bioprod Biorefin 13(1):208–227. https://doi.org/10.1002/bbb.1944
Fernández D, Rodríguez E, Bassas M et al (2005) Agro-industrial oily wastes as substrates for PHA production by the new strain Pseudomonas aeruginosa NCIB 40045: effect of culture conditions. Biochem Eng J 26(2–3):159–167. https://doi.org/10.1016/j.bej.2005.04.022
Gao C, Qi Q, Madzak C, Lin CS (2015) Exploring medium-chain-length polyhydroxyalkanoates production in the engineered yeast Yarrowia lipolytica. J Ind Microbiol Biotechnol 42:1255–1262. https://doi.org/10.1007/s10295-015-1649-y
Getachew A, Woldesenbet F (2016) Production of biodegradable plastic by polyhydroxybutyrate (PHB) accumulating bacteria using low cost agricultural waste material. BMC Res Notes 9:509. https://doi.org/10.1186/s13104-016-2321-y
Giedraitytė G, Kalėdienė L (2015) Purification and characterization of polyhydroxybutyrate produced from thermophilic Geobacillus sp. AY 946034 strain. Chemija 26(1):38–45
González-Torres M, Ramírez-Mata A, Melgarejo-Ramírez Y et al (2020) Assessment of biocompatibility and surface topography of poly (ester urethane)–silica nanocomposites reveal multifunctional properties. Mater Lett 8:128269. https://doi.org/10.1016/j.matlet.2020.128269
Goto S, Hokamura A, Shiratsuchi H et al (2019) Biosynthesis of novel lactate-based polymers containing medium-chain-length 3-hydroxyalkanoates by recombinant Escherichia coli strains from glucose. J Biosci Bioeng 128(2):191–197. https://doi.org/10.1016/j.jbiosc.2019.01.009
Goudarzi V, Shahabi-Ghahfarrokhi I (2018) Development of photo-modified starch/kefiran/TiO2 bio-nanocomposite as an environmentally-friendly food packaging material. Int J Biol Macromol 116:1082–1088. https://doi.org/10.1016/j.ijbiomac.2018.05.138
Gouveia AR, Freitas EB, Galinha CF et al (2017) Dynamic change of pH in acidogenic fermentation of cheese whey towards polyhydroxyalkanoates production: impact on performance and microbial population. New Biotechnol 37:108–116. https://doi.org/10.1016/j.nbt.2016.07.001
Gowda V, Shivakumar S (2014) Agrowaste-based polyhydroxyalkanoate (PHA) production using hydrolytic potential of Bacillus thuringiensis IAM 12077. Braz Arch Biol Technol 57(1):55–61. https://doi.org/10.1590/S1516-89132014000100009
Gumel AM, Annuar MS (2014) Nanocomposites of polyhydroxyalkanoates (PHAs). In: Polyhydroxyalkanoate (PHA) based blends, composites and nanocomposites, RSC green chemistry series, vol 30. RSC, Cambridge, pp 98–118. https://doi.org/10.1039/9781782622314
Guzik MW, Kenny ST, Duane GF et al (2014) Conversion of post consumer polyethylene to the biodegradable polymer polyhydroxyalkanoate. Appl Microbiol Biotechnol 98(9):4223–4232. https://doi.org/10.1007/s00253-013-5489-2
Haas R, Jin B, Zepf FT (2008) Production of poly (3-hydroxybutyrate) from waste potato starch. Biosci Biotechnol Biochem 23:0712210692. https://doi.org/10.1271/bbb.70503
Haddouche R, Poirier Y, Delessert S et al (2011) Engineering polyhydroxyalkanoate content and monomer composition in the oleaginous yeast Yarrowia lipolytica by modifying the β-oxidation multifunctional protein. Appl Microbiol Biotechnol 91:1327. https://doi.org/10.1007/s00253-011-3331-2
Halevas EG, Pantazaki AA (2018) Polyhydroxyalkanoates: chemical structure. Biosynthesis, chemical structures and applications. Materials science and technologies. Nova Science publishers, New York, NY, p 133
Han J, Zhang F, Hou J et al (2012) Complete genome sequence of the metabolically versatile halophilic archaeon Haloferax mediterranei, a poly (3-hydroxybutyrate-co-3-hydroxyvalerate) producer. J Bacteriol 194:4463–4464. https://doi.org/10.1128/JB.00880-12
Hong YG, Moon YM, Hong JW et al (2019) Discarded egg yolk as an alternate source of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate). J Microbiol Biotechnol 29(3):382–391. https://doi.org/10.4014/jmb.1811.11028
Hori K, Kobayashi A, Ikeda H et al (2009) Rhodococcus aetherivorans IAR1, a new bacterial strain synthesizing poly (3-hydroxybutyrate-co-3-hydroxyvalerate) from toluene. J Biosci Bioeng 107(2):145–150. https://doi.org/10.1016/j.jbiosc.2008.10.005
Hsiao LJ, Lin JH, Sankatumvong P et al (2016) The feasibility of thermophilic Caldimonas manganoxidans as a platform for efficient PHB production. Appl Biochem Biotechnol 180(5):852–871. https://doi.org/10.1007/s12010-016-2138-0
Ibrahim MH, Steinbüchel A (2010a) Zobellella denitrificans strain MW1, a newly isolated bacterium suitable for poly (3-hydroxybutyrate) production from glycerol. J Appl Microbiol 108(1):214–225. https://doi.org/10.1111/j.1365-2672.2009.04413.x
Ibrahim MHA, Steinbüchel A (2010b) High-cell-density cyclic fed-batch fermentation of a poly (3-hydroxybutyrate)-accumulating thermophile, Chelatococcus sp.strain MW10. Appl Environ Microbiol 76(23):7890–7895. https://doi.org/10.1128/aem.01488-10
Ibrahim MHA, Willems A, Steinbuchel A (2010) Isolation and characterization of new poly(3HB)-accumulating star-shaped cell-aggregates-forming thermophilic bacteria. J Appl Microbiol 109(5):1579–1590. https://doi.org/10.1111/j.1365-2672.2010.04786.x
Ibrahim MHA, Lebbe L, Willems A et al (2016) Chelatococcus thermostellatus sp. Nov., a new thermophile for bioplastic synthesis: comparative phylogenetic and physiological study. AMB Express 6(1):39. https://doi.org/10.1186/s13568-016-0209-9
Ismail NI, Bakar MA, Bakar NH (2018) Synthesis of poly (3-hydroxybutyrate)/copper sulfide composites films and their photocatalytic application. J Phys Sci 29:115–123. https://doi.org/10.21315/jps2018.29.s1.15
Israni N, Venkatachalam P, Gajaraj B et al (2020) Whey valorization for sustainable polyhydroxyalkanoate production by Bacillus megaterium: production, characterization and in vitro biocompatibility evaluation. J Environ Manag 255:109884. https://doi.org/10.1016/j.jenvman.2019.109884
Jaiswal L, Shankar S, Rhim JW (2019) Applications of nanotechnology in food microbiology. Methods Microbiol 46:43–60. https://doi.org/10.1016/bs.mim.2019.03.002
Jayakumar A, Prabhu K, Shah L et al (2020) Biologically and environmentally benign approach for PHB-silver nanocomposite synthesis and its characterization. Polym Test 81:106197. https://doi.org/10.1016/j.polymertesting.2019.106197
Jeon JM, Kim HJ, Bhatia SK et al (2017) Application of acetyl-CoA acetyl transferase (AtoAD) in Escherichia coli to increase 3-hydroxyvalerate fraction in poly (3-hydroxybutyrate-co-3-hydroxyvalerate). Bioprocess Biosyst Eng 40:781–789. https://doi.org/10.1007/s00449-017-1743-9
Jiang G, Hill DJ, Kowalczuk M et al (2016) Carbon sources for polyhydroxyalkanoates and an integrated biorefinery. Int J Mol Sci 17(7):1157. https://doi.org/10.3390/ijms17071157
Johnston B, Jiang G, Hill D et al (2017) The molecular level characterization of biodegradable polymers originated from polyethylene using non-oxygenated polyethylene wax as a carbon source for polyhydroxyalkanoate production. Bioengineering 4(3):73. https://doi.org/10.3390/bioengineering4030073
Jossek R, Steinbüchel A (1998) In vitro synthesis of poly (3-hydroxybutyric acid) by using an enzymatic coenzyme A recycling system. FEMS Microbiol Lett 168(2):319–324. https://doi.org/10.1111/j.1574-6968.1998.tb13290.x
Ju D, Han L, Li F et al (2014) Poly (ɛ-caprolactone) composites reinforced by biodegradable poly (3-hydroxybutyrate-co-3-hydroxyvalerate) fiber. Int J Biol Macromol 67:343–350. https://doi.org/10.1016/j.ijbiomac.2014.03.048
Jung HR, Jeon JM, Yi DH et al (2019a) Poly (3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) terpolymer production from volatile fatty acids using engineered Ralstonia eutropha. Int J Biol Macromol 138:370–378
Jung HR, Yang SY, Moon YM et al (2019b) Construction of efficient platform Escherichia coli strains for polyhydroxyalkanoate production by engineering branched pathway. Polymers 11(3):509. https://doi.org/10.3390/polym11030509
Jurasek L, Marchessault RH (2004) Polyhydroxyalkanoate (PHA) granule formation in Ralstonia eutropha cells: a computer simulation. Appl Microbiol Biotechnol 64(5):611–617. https://doi.org/10.1007/s00253-003-1551-9
Kai D, Loh XJ (2014) Polyhydroxyalkanoates: chemical modifications toward biomedical applications. ACS Sustain Chem Eng 2(2):106–119. https://doi.org/10.1021/sc400340p
Kato M, Bao HJ, Kang CK et al (1996) Production of a novel copolyester of 3-hydroxybutyric acid and medium-chain-length 3-hydroxyalkanoic acids by Pseudomonas sp. 61-3 from sugars. Appl Microbiol Biotechnol 45(3):363–370. https://doi.org/10.1007/s002530050697
Kerketta A, Vasanth D (2019) Madhuca indica flower extract as cheaper carbon source for production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) using Ralstonia eutropha. Process Biochem 87:1–9. https://doi.org/10.1016/j.procbio.2019.09.013
Kilicay E, Erdal E, Hazer B et al (2016) Antisense oligonucleotide delivery to cancer cell lines for the treatment of different cancer types. Artif Cells Nanomed Biotechnol 44(8):1938–1948. https://doi.org/10.3109/21691401.2015.1115409
Kimura H, Yamamoto T, Iwakura K (2002) Biosynthesis of polyhydroxyalkanoates from 1, 3-propanediol by Chromobacterium sp. Polym J 34:659–665. https://doi.org/10.1295/polymj.34.659
Koller M (2017) Advances in polyhydroxyalkanoate (PHA) production. Bioengineering 4(4):88. https://doi.org/10.3390/bioengineering4040088
Koller M (2018) Chemical and biochemical engineering approaches in manufacturing polyhydroxyalkanoate (PHA) biopolyesters of tailored structure with focus on the diversity of building blocks. Chem Biochem Eng Q 32:413–438. https://doi.org/10.15255/CABEQ.2018.1385
Koller M (2020) Advances in polyhydroxyalkanoate (PHA) production, Vol 2. Bioengineering (Basel) 7:24
Koller M, Bona R, Chiellini E et al (2008) Polyhydroxyalkanoate production from whey by Pseudomonas hydrogenovora. Bioresour Technol 99(11):4854–4863. https://doi.org/10.1016/j.biortech.2007.09.049
Koller M, Dias MM, Rodríguez-Contreras A et al (2015) Liquefied wood as inexpensive precursor-feedstock for bio-mediated incorporation of (R)-3-hydroxyvalerate into polyhydroxyalkanoates. Materials 8(9):6543–6557. https://doi.org/10.3390/ma8095321
Koller M, Hesse P, Braunegg G (2019) Application of whey retentate as complex nitrogen source for growth of the polyhydroxyalkanoate producer Hydrogenophaga pseudoflava strain DSM1023. Eurobiotech J 3(2):78–89. https://doi.org/10.2478/ebtj-2019-0009
Kourmentza C, Plácido J, Venetsaneas N et al (2017) Recent advances and challenges towards sustainable polyhydroxyalkanoate (PHA) production. Bioengineering 4(2):55. https://doi.org/10.3390/bioengineering4020055
Kourmentza C, Costa J, Azevedo Z et al (2018) Burkholderia thailandensis as a microbial cell factory for the bioconversion of used cooking oil to polyhydroxyalkanoates and rhamnolipids. Bioresour Technol 247:829–837. https://doi.org/10.1016/j.biortech.2017.09.138
Kulkarni SO, Kanekar PP, Jog JP et al (2015) Production of copolymer, poly (hydroxybutyrate-co-hydroxyvalerate) by Halomonas campisalis MCM B-1027 using agro-wastes. Int J Biol Macromol 72:784–789. https://doi.org/10.1016/j.ijbiomac.2014.09.028
Kumar G, Ponnusamy VK, Bhosale RR et al (2019) A review on the conversion of volatile fatty acids to polyhydroxyalkonates using dark fermentative effluents from hydrogen production. Bioresour Technol 287:121427. https://doi.org/10.1016/j.biortech.2019.121427
Kumari SV, Manikandan NA, Pakshirajan K et al (2020) Sustained drug release and bactericidal activity of a novel, highly biocompatible and biodegradable polymer nanocomposite loaded with norfloxacin for potential use in antibacterial therapy. J Drug Deliv Sci Technol 18:101900. https://doi.org/10.1016/j.jddst.2020.101900
Lee RE, Azdast T, Wang G et al (2020) Highly expanded fine-cell foam of polylactide/polyhydroxyalkanoate/nano-fibrillated polytetrafluoroethylene composites blown with mold-opening injection molding. Int J Biol Macromol 155:286. https://doi.org/10.1016/j.ijbiomac.2020.03.212
Lettner M, Schöggl JP, Stern T (2017) Factors influencing the market diffusion of bio-based plastics: results of four comparative scenario analyses. J Clean Prod 157:289–298. https://doi.org/10.1016/j.jclepro.2017.04.077
Ling C, Qiao GQ, Shuai BW et al (2018) Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA). Metab Eng 49:275–286. https://doi.org/10.1016/j.ymben.2018.09.007
Liu Y, Huang S, Zhang Y et al (2014) Isolation and characterization of a thermophilic Bacillus shackletonii K5 from a bio trickling filter for the production of polyhydroxybutyrate. J Environ Sci 26(7):1453–1462. https://doi.org/10.1016/j.jes.2014.05.011
Liu Y, Guo L, Liao Q et al (2020) Polyhydroxyalkanoate (PHA) production with acid or alkali pretreated sludge acidogenic liquid as carbon source: substrate metabolism and monomer composition. Process Saf Environ 142:156. https://doi.org/10.1016/j.psep.2020.06.015
Lorenzini C, Versace DL, Babinot J et al (2014) Biodegradable hybrid poly (3-hydroxyalkanoate) s networks through silsesquioxane domains formed by efficient UV-curing. React Funct Polym 84:53–59. https://doi.org/10.1016/j.reactfunctpolym.2014.09.008
Lorenzini C, Versace DL, Renard E et al (2015) Renewable epoxy networks by photoinitiated copolymerization of poly (3-hydroxyalkanoate) s and isosorbide derivatives. React Funct Polym 93:95–100. https://doi.org/10.1016/j.reactfunctpolym.2015.06.007
Ma P, Hristova-Bogaerds DG, Lemstra PJ et al (2012) Toughening of PHBV/PBS and PHB/PBS blends via in situ compatibilization using dicumyl peroxide as a free-radical grafting initiator. Macromol Mater Eng 297(5):402–410. https://doi.org/10.1002/mame.201100224
Ma P, Cai X, Wang W et al (2014) Crystallization behavior of partially crosslinked poly (β-hydroxyalkonates)/poly (butylene succinate) blends. J Appl Polym Sci 131(21):41020. https://doi.org/10.1002/app.41020
Maiti P, Batt CA, Giannelis EP (2007) New biodegradable polyhydroxybutyrate/layered silicate nanocomposites. Biomacromolecules 8(11):3393–3400. https://doi.org/10.1021/bm700500t
Mannina G, Presti D, Montiel-Jarillo G et al (2020) Recovery of polyhydroxyalkanoates (PHAs) from wastewater: a review. Bioresour Technol 297:122478. https://doi.org/10.1016/j.biortech.2019.122478
Masood F, Aziz M, Haider H et al (2018) Biodegradation of gamma irradiated poly-3-hydroxybutyrate/sepiolite nanocomposites. Int Biodeterior Biodegradation 126:1–9. https://doi.org/10.1016/j.ibiod.2017.09.012
Masood F, Haider H, Yasin T (2019) Sepiolite/poly-3-hydroxyoctanoate nanocomposites: effect of clay content on physical and biodegradation properties. Appl Clay Sci 175:130–138. https://doi.org/10.1016/j.clay.2019.04.012
Miao L, Qiu Z, Yang W et al (2008) Fully biodegradable poly (3-hydroxybutyrate-co-hydroxyvalerate)/poly (ethylene succinate) blends: phase behavior, crystallization and mechanical properties. React Funct Polym 68(2):446–457. https://doi.org/10.1016/j.reactfunctpolym.2007.11.001
Mifune J, Nakamura S, Fukui T (2010) Engineering of PHA operon on Cupriavidus necator chromosome for efficient biosynthesis of poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) from vegetable oil. Polym Degrad Stab 95(8):1305–1312. https://doi.org/10.1016/j.polymdegradstab.2010.02.026
Mofokeng JP, Luyt AS (2015) Morphology and thermal degradation studies of melt-mixed poly (hydroxybutyrate-co-valerate)(PHBV)/poly (ε-caprolactone)(PCL) biodegradable polymer blend nanocomposites with TiO2 as filler. J Mater Sci 50(10):3812–3824. https://doi.org/10.1007/s10853-015-8950-z
Możejko-Ciesielska J, Kiewisz R (2016) Bacterial polyhydroxyalkanoates: still fabulous? Microbiol Res 192:271–282. https://doi.org/10.1016/j.micres.2016.07.010
Mudenur C, Mondal K, Singh U et al (2019) Production of polyhydroxyalkanoates and its potential applications. In: Advances in sustainable polymers. Springer, Singapore, pp 131–164
Muhammadi S, Afzal M et al (2015) Bacterial polyhydroxyalkanoates-eco-friendly next generation plastic: production, biocompatibility, biodegradation, physical properties and applications. Green Chem Lett Rev 8(3–4):56–77. https://doi.org/10.1080/17518253.2015.1109715
Mukheem A, Muthoosamy K, Manickam S et al (2018) Fabrication and characterization of an electrospun PHA/graphene silver nanocomposite scaffold for antibacterial applications. Materials 11(9):1673. https://doi.org/10.3390/ma11091673
Muniyasamy S, Ofosu O, Thulasinathan B et al (2019) Thermal-chemical and biodegradation behaviour of alginic acid treated flax fibres/poly (hydroxybutyrate-co-valerate) PHBV green composites in compost medium. Biocatal Agric Biotechnol 22:101394. https://doi.org/10.1016/j.bcab.2019.101394
Munoz LEA, Riley MR (2008) Utilization of cellulosic waste from tequila bagasse and production of polyhydroxyalkanoate (PHA) bioplastics by Saccharophagus degradans. Biotechnol Bioeng 100:882–888. https://doi.org/10.1002/bit.21854
Nagarajan V, Misra M, Mohanty AK (2013) New engineered biocomposites from poly (3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV)/poly (butylene adipate-co-terephthalate)(PBAT) blends and switch grass: fabrication and performance evaluation. Ind Crop Prod 42:461–468. https://doi.org/10.1016/j.indcrop.2012.05.042
Naphade R, Jog J (2012) Electrospinning of PHBV/ZnO membranes: structure and properties. Fiber Polym 13(6):692–697. https://doi.org/10.1007/s12221-012-0692-9
Nar M, Staufenberg G, Yang B et al (2014) Osteoconductive bio-based meshes based on Poly (hydroxybutyrate-co-hydroxyvalerate) and poly (butylene adipate-co-terephthalate) blends. Mater Sci Eng C 38:315–324. https://doi.org/10.1016/j.msec.2014.01.047
Ng KS, Ooi WY, Goh LK et al (2010) Evaluation of jatropha oil to produce poly (3-hydroxybutyrate) by Cupriavidus necator H16. Polym Degrad Stab 95(8):1365–1369. https://doi.org/10.1016/j.polymdegradstab.2010.01.021
Nishioka M, Nakai K, Miyake M et al (2001) Production of poly-β-hydroxybutyrate by thermophilic cyanobacterium, Synechococcus sp. MA19, under phosphate limited conditions. Biotechnol Lett 23(14):1095–1099. https://doi.org/10.1023/a:1010551614648
Obruca S, Sedlacek P, Koller M et al (2018) Involvement of polyhydroxyalkanoates in stress resistance of microbial cells: biotechnological consequences and applications. Biotechnol Adv 36:856–870. https://doi.org/10.1016/j.biotechadv.2017.12.006
Ojha N, Das N (2017) Optimization and characterization of polyhydroxyalkanoates and its copolymers synthesized by isolated yeasts. Res J Pharm Technol 10:861. https://doi.org/10.5958/0974-360X.2017.00161.5
Ojha N, Das N (2018) A Statistical approach to optimize the production of polyhydroxyalkanoates from Wickerhamomyces anomalus VIT-NN01 using response surface methodology. Int J Biol Macromol 107:2157–2170. https://doi.org/10.1016/j.ijbiomac.2017.10.089
Ojha N, Das N (2020a) Process optimization and characterization of polyhydroxyalkanoate copolymers produced by marine Pichia kudriavzevii VIT-NN02 using banana peels and chicken feather hydrolysate. Biocatal Agric Biotechnol 17:101616. https://doi.org/10.1016/j.bcab.2020.101616
Ojha N, Das N (2020b) Fabrication and characterization of biodegradable PHBV/SiO2 nanocomposite for thermo-mechanical and antibacterial applications in food packaging. IET Nanobiotechnol 14:785–795
Oliveira CS, Silva MO, Silva CE et al (2018) Assessment of protein-rich cheese whey waste stream as a nutrients source for low-cost mixed microbial PHA production. Appl Sci 8(10):1817. https://doi.org/10.3390/app8101817
Omri N, Amine Oualha M, Brison L et al (2020) Novel nanocomposite based on EVA/PHBV/[60] fullerene with improved thermal properties. Polym Test 81:106277. https://doi.org/10.1016/j.polymertesting.2019.106277
Ong YT, Ahmad AL, Zein SH, Sudesh K, Tan SH et al (2011) Poly (3-hydroxybutyrate)-functionalized multi-walled carbon nanotubes/chitosan green nanocomposite membranes and their application in pervaporation. Sep Purif Technol 76(3):419–427. https://doi.org/10.1016/j.seppur.2010.11.013
Oprea M, Panaitescu DM, Nicolae CA et al (2020) Nanocomposites from functionalized bacterial cellulose and poly (3-hydroxybutyrate-co-3-hydroxyvalerate). Polym Degrad Stab 13:109203. https://doi.org/10.1016/j.polymdegradstab.2020.109203
Pacheco N, Orellana-Saez M, Pepczynska M et al (2019) Exploiting the natural poly (3-hydroxyalkanoates) production capacity of Antarctic Pseudomonas strains: from unique phenotypes to novel biopolymers. J Ind Microbiol Biotechnol 46(8):1139–1153. https://doi.org/10.1007/s10295-019-02186-2
Page WJ (1992) Production of polyhydroxyalkanoates by Azotobacter vinelandii UWD in beet molasses culture. FEMS Microbiol Rev 9(2–4):149–157. https://doi.org/10.1111/j.1574-6968.1992.tb05832.x
Pagliano G, Ventorino V, Panico A et al (2017) Integrated systems for biopolymers and bioenergy production from organic waste and by-products: a review of microbial processes. Biotechnol Biofuel 10(1):113. https://doi.org/10.1186/s13068-017-0802-4
Pal AK, Wu F, Misra M et al (2020) Reactive extrusion of sustainable PHBV/PBAT-based nanocomposite films with organically modified nanoclay for packaging applications: compression moulding vs. cast film extrusion. Compos B Eng 13:108141. https://doi.org/10.1016/j.compositesb.2020.108141
Pan W, Perrotta JA, Stipanovic AJ et al (2012) Production of polyhydroxyalkanoates by Burkholderia cepacia ATCC 17759 using a detoxified sugar maple hemicellulosic hydrolysate. J Ind Microbiol Biotechnol 39:459–469. https://doi.org/10.1007/s10295-011-1040-6
Pantazaki AA, Tambaka MG, Langlois V et al (2003) Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase. Mol Cell Biochem 254:173–183. https://doi.org/10.1023/A:1027373100955
Pantazaki AA, Ioannou AK, Kyriakidis DA (2005) A thermostable beta-ketothiolase of polyhydroxyalkanoates (PHAs) in Thermus thermophilus: purification and biochemical properties. Mol Cell Biochem 269(1–2):27–36. https://doi.org/10.1007/s11010-005-2992-5
Park YL, Bhatia SK, Gurav R et al (2020) Fructose based hyper production of poly-3-hydroxybutyrate from Halomonas sp. YLGW01 and impact of carbon sources on bacteria morphologies. Int J Biol Macromol 154:929. https://doi.org/10.1016/j.ijbiomac.2020.03.129
Parvizifard M, Karbasi S (2020) Physical, mechanical and biological performance of PHB-Chitosan/MWCNTs nanocomposite coating deposited on bioglass based scaffold: potential application in bone tissue engineering. Int J Biol Macromol 152:645. https://doi.org/10.1016/j.ijbiomac.2020.02.266Get
de Paula FC, Kakazu S, de Paula CBC et al (2019) Burkholderia glumae MA13: a newly isolated bacterial strain suitable for polyhydroxyalkanoate production from crude glycerol. Biocatal Agric Biotechnol 20:101268. https://doi.org/10.1016/j.bcab.2019.101268
Peprah BA, Ramsay JA, Ramsay BA (2018) Stabilization and characterization of carboxylated medium-chain-length poly (3-hydroxyalkanoate) nanosuspensions. Int J Biol Macromol 108:902–908. https://doi.org/10.1016/j.ijbiomac.2017.10.181
Pérez-Arauz AO, Aguilar-Rabiela AE, Vargas-Torres A et al (2019) Production and characterization of biodegradable films of a novel polyhydroxyalkanoate (PHA) synthesized from peanut oil. Food Packag Shelf Life 20:100297. https://doi.org/10.1016/j.fpsl.2019.01.001
Pernicova I, Kucera D, Nebesarova J et al (2019) Production of polyhydroxyalkanoates on waste frying oil employing selected Halomonas strains. Bioresour Technol 292:122028. https://doi.org/10.1016/j.biortech.2019.122028
Perveen K, Masood F, Hameed A (2020) Preparation, characterization and evaluation of antibacterial properties of epirubicin loaded PHB and PHBV nanoparticles. Int J Biol Macromol 144:259–266. https://doi.org/10.1016/j.ijbiomac.2019.12.049
Peters V, Rehm BH (2005) In vivo monitoring of PHA granule formation using GFP-labeled PHA synthases. FEMS Microbiol Lett 248(1):93–100. https://doi.org/10.1016/j.femsle.2005.05.027
Phukon P, Saikia JP, Konwar BK (2011) Enhancing the stability of colloidal silver nanoparticles using polyhydroxyalkanoates (PHA) from Bacillus circulans (MTCC 8167) isolated from crude oil contaminated soil. Coll Surf B 86(2):314–318. https://doi.org/10.1016/j.colsurfb.2011.04.014
Poirier Y, Erard N, Petétot JMC (2001) Synthesis of polyhydroxyalkanoate in the peroxisome of Saccharomyces cerevisiae by using intermediates of fatty acid β-oxidation. Appl Environ Microbiol 67:5254–5260. https://doi.org/10.1128/AEM.67.11.5254-5260.2001
Poirier Y, Erard N, Petétot JMC (2002) Synthesis of polyhydroxyalkanoate in the peroxisome of Pichia pastoris. FEMS Microbiol Lett 207:97–102. https://doi.org/10.1111/j.1574-6968.2002.tb11035.x
Pradhan N, Singh S, Ojha N et al (2015) Facets of nanotechnology as seen in food processing, packaging, and preservation industry. Biomed Res Int 2015:365672. https://doi.org/10.1155/2015/365672
Prakalathan K, Mohanty S, Nayak SK (2014) Reinforcing effect and isothermal crystallization kinetics of poly (3-hydroxybutyrate) nanocomposites blended with organically modified montmorillonite. Polym Compos 35(5):999–1012. https://doi.org/10.1002/pc.22746
Prakasan P, Sajith S, Sreedevi S et al (2016) Candida tropicalis BPU1 produces polyhydroxybutyrate on raw starchy substrates. Starke 68:57–66. https://doi.org/10.1002/star.201500086
Prem Anand AA, Vennison SJ, Sankar SG et al (2010) Isolation and characterization of bacteria from the gut of Bombyx mori that degrade cellulose, xylan, pectin and starch and their impact on digestion. J Insect Sci 10(1):107. https://doi.org/10.1673/031.010.10701
Qi Q, Steinbüchel A, Rehm BH (2000) In vitro synthesis of poly (3-hydroxydecanoate): purification and enzymatic characterization of type II polyhydroxyalkanoate synthases PhaC1 and PhaC2 from Pseudomonas aeruginosa. Appl Microbiol Biotechnol 54(1):37–43. https://doi.org/10.1007/s002530000357
Qiu Z, Ikehara T, Nishi T (2003) Miscibility and crystallization behaviour of biodegradable blends of two aliphatic polyesters. Poly (3-hydroxybutyrate-co-hydroxyvalerate) and poly (butylene succinate) blends. Polymer 44(24):7519–7527. https://doi.org/10.1016/j.polymer.2003.09.029
Quillaguaman J, Hashim S, Bento F et al (2005) Poly (β-hydroxybutyrate) production by a moderate halophile, Halomonas boliviensis LC1 using starch hydrolysate as substrate. J Appl Microbiol 99(1):151–157. https://doi.org/10.1111/j.1365-2672.2005.02589.x
Ramadas NV, Singh SK, Soccol CR et al (2009) Polyhydroxybutyrate production using agro-industrial residue as substrate by Bacillus sphaericus NCIM 5149. Braz Arch Biol Technol 52:17–23. https://doi.org/10.1590/S1516-89132009000100003
Ray S, Sharma R, Kalia VC (2018) Co-utilization of crude glycerol and biowastes for producing polyhydroxyalkanoates. Indian J Microbiol 58(1):33–38. https://doi.org/10.1007/s12088-017-0702-0
Reddy MV, Watanabe A, Onodera R et al (2020) Polyhydroxyalkanoates (PHA) production using single or mixture of fatty acids with Bacillus sp. CYR1: identification of PHA synthesis genes. Bioresour Technol Rep 23:100483. https://doi.org/10.1016/j.biteb.2020.100483
Rehm BH, Qi Q, Beermann BB, Hinz HJ, Steinbüchel A (2001) Matrix-assisted in vitro refolding of Pseudomonas aeruginosa class II polyhydroxyalkanoate synthase from inclusion bodies produced in recombinant Escherichia coli. Biochem J 358:263–268. https://doi.org/10.1042/bj3580263
Rezende JC, Bravo AH, Nahat RA et al (2020) The relevance of enzyme specificity for coenzymes and the presence of 6-phosphogluconate dehydrogenase for polyhydroxyalkanoates production in the metabolism of Pseudomonas sp. LFM046. Int J Biol Macromol 163:240. https://doi.org/10.1016/j.ijbiomac.2020.06.226
Riaz S, Raza ZA, Majeed MI et al (2018) Synthesis of zinc sulfide nanoparticles and their incorporation into poly (hydroxybutyrate) matrix in the formation of a novel nanocomposite. Mater Res Express 5(5):055027
Riaz S, Raza ZA, Majeed MI (2020) Preparation of cadmium sulfide nanoparticles and mediation thereof across poly (hydroxybutyrate) nanocomposite. Polym Bull 77(2):775–791. https://doi.org/10.1007/s00289-019-02775-2
Rivera-Briso AL, Serrano-Aroca Á (2018) Poly (3-hydroxybutyrate-co-3-hydroxyvalerate): enhancement strategies for advanced applications. Polymers 10(7):732. https://doi.org/10.3390/polym10070732
Rizzo MG, Nicolò MS, Franco D et al (2019) Glutamine-induced filamentous cells of Pseudomonas mediterranea CFBP-5447T as producers of PHAs. Appl Microbiol Biotechnol 103(21–22):9057–9066. https://doi.org/10.1007/s00253-019-10144-2
Roja K, Sudhakar DR, Anto S et al (2019) Extraction and characterization of polyhydroxyalkanoates from marine green alga and cyanobacteria. Biocatal Agric Biotechnol 22:101358. https://doi.org/10.1016/j.bcab.2019.101358
Rostkowski KH, Pfluger AR, Criddle CS (2013) Stoichiometry and kinetics of the PHB-producing type II methanotrophs Methylosinus trichosporium OB3b and Methylocystis parvus OBBP. Bioresour Technol 132:71–77. https://doi.org/10.1016/j.biortech.2012.12.129
Sabapathy PC, Devaraj S, Parthiban A et al (2019) Aegle marmelos: a novel low cost substrate for the synthesis of polyhydroxyalkanoate by Bacillus aerophilus RSL-7. Biocatal Agric Biotechnol 18:101021
Sabapathy PC, Devaraj S, Meixner K et al (2020) Recent developments in polyhydroxyalkanoates (PHAs) production in the past decade–a review. Bioresour Technol 12:123132. https://doi.org/10.1016/j.biortech.2020.123132
Safaei M, Taran M, Jamshidy L et al (2020) Optimum synthesis of polyhydroxybutyrate-Co3O4 bionanocomposite with the highest antibacterial activity against multidrug resistant bacteria. Int J Biol Macromol 158:477. https://doi.org/10.1016/j.ijbiomac.2020.04.017
Sandström AG, De Las Heras AM, Portugal-Nunes D et al (2015) Engineering of Saccharomyces cerevisiae for the production of poly-3-d-hydroxybutyrate from xylose. AMB Express 5:14. https://doi.org/10.1186/s13568-015-0100-0
Sathiyanarayanan G, Bhatia SK, Song HS et al (2017) Production and characterization of medium-chain-length polyhydroxyalkanoate copolymer from Arctic psychrotrophic bacterium Pseudomonas sp. PAMC 28620. Int J Biol Macromol 97:710–720. https://doi.org/10.1016/j.ijbiomac.2017.01.053
Segawa M, Wen C, Orita I et al (2019) Two NADH-dependent (S)-3-hydroxyacyl-CoA dehydrogenases from polyhydroxyalkanoate-producing Ralstonia eutropha. J Biosci Bioeng 127(3):294–300. https://doi.org/10.1016/j.jbiosc.2018.08.009
Senthilkumar P, Dawn SS, Samanvitha KS et al (2017) Optimization and characterization of poly [R] hydroxyalkanoate of Pseudomonas aeruginosa SU-1 to utilize in nanoparticle synthesis for curcumin delivery. Biocatal Agric Biotechnol 12:292–298. https://doi.org/10.1016/j.bcab.2017.10.019
Shah M, Naseer MI, Choi MH et al (2010) Amphiphilic PHA–mPEG copolymeric nanocontainers for drug delivery: preparation, characterization and in vitro evaluation. Int J Pharm 400(1–2):165–175. https://doi.org/10.1016/j.ijpharm.2010.08.008
Shah M, Choi MH, Ullah N et al (2011) Synthesis and characterization of PHV-block-mPEG diblock copolymer and its formation of amphiphilic nanoparticles for drug delivery. J Nanosci Nanotechnol 11(7):5702–5710. https://doi.org/10.1166/jnn.2011.4493
Shah M, Ullah N, Choi MH et al (2012) Amorphous amphiphilic P (3HV-co-4HB)-b-mPEG block copolymer synthesized from bacterial copolyester via melt transesterification: nanoparticle preparation, cisplatin-loading for cancer therapy and in vitro evaluation. Eur J Pharm Biopharm 80(3):518–527. https://doi.org/10.1016/j.ejpb.2011.11.014
Sharma PK, Munir RI, de Kievit T et al (2017) Synthesis of polyhydroxyalkanoates (PHAs) from vegetable oils and free fatty acids by wild-type and mutant strains of Pseudomonas chlororaphis. Can J Microbiol 63(12):1009–1024. https://doi.org/10.1139/cjm-2017-0412
Shrivastav A, Mishra SK, Pancha I et al (2011) Biodegradability studies of polyhydroxyalkanoate (PHA) film produced by a marine bacteria using Jatropha biodiesel by product as a substrate. World J Microbiol Biotechnol 27:1531–1541. https://doi.org/10.1007/s11274-010-0605-2
Shrivastav A, Kim HY, Kim YR (2013) Advances in the applications of polyhydroxyalkanoate nanoparticles for novel drug delivery system. Biomed Res Int 2013:581684. https://doi.org/10.3390/polym10070732
Silva LF, Taciro MK, Ramos MM et al (2004) Poly-3-hydroxybutyrate (P3HB) production by bacteria from xylose, glucose and sugarcane bagasse hydrolysate. J Ind Microbiol Biotechnol 31(6):245–254. https://doi.org/10.1007/s10295-004-0136-7
da Silva DD, de Menezes LR et al (2019) Evaluation of thermal properties of zirconium–PHB composites. J Therm Anal Calorim 11:1–8. https://doi.org/10.1007/s10973-019-09106-7
Singh AK, Sharma L, Srivastava JK et al (2018) Microbially originated polyhydroxyalkanoate (PHA) biopolymers: an insight into the molecular mechanism and biogenesis of PHA granules. In: Sustainable biotechnology-enzymatic resources of renewable energy. Springer, Cham, pp 355–398
Singh AK, Srivastava JK, Chandel AK et al (2019) Biomedical applications of microbially engineered polyhydroxyalkanoates: an insight into recent advances, bottlenecks, and solutions. Appl Microbiol Biotechnol 103(5):2007–2032. https://doi.org/10.1007/s00253-018-09604-y
Steinbüchel A, Wiese S (1992) A Pseudomonas strain accumulating polyesters of 3-hydroxybutyric acid and medium-chain-length 3-hydroxyalkanoic acids. Appl Microbiol Biotechnol 37(6):691–697. https://doi.org/10.1007/BF00174829
Sudesh K, Abe H, Doi Y (2000) Synthesis, structure and properties of polyhydroxyalkanoates: biological polyesters. Prog Polym Sci 25:1503–1555. https://doi.org/10.1016/S0079-6700(00)00035-6
Sun J, Shen J, Chen S et al (2018) Nanofiller reinforced biodegradable PLA/PHA composites: current status and future trends. Polymers 10(5):505
Taguchi K, Aoyagi Y, Matsusaki H, Fukui T, Doi Y (1999) Over-expression of 3-ketoacyl-ACP synthase III or malonyl-CoA-ACP transacylase gene induces monomer supply for polyhydroxybutyrate production in Escherichia coli HB101. Biotechnol Lett 21:579–584. https://doi.org/10.1023/A:1005572526080
Takisawa K, Ooi T, Matsumoto KI et al (2017) (2017) Xylose-based hydrolysate from eucalyptus extract as feedstock for poly (lactate-co-3-hydroxybutyrate) production in engineered Escherichia coli. Process Biochem 54:102–105. https://doi.org/10.1016/j.procbio.2016.12.019
Tan GY, Chen CL, Ge L et al (2015) Bioconversion of styrene to poly (hydroxyalkanoate)(PHA) by the new bacterial strain Pseudomonas putida NBUS12. Microbes Environ 30:76. https://doi.org/10.1264/jsme2.ME14138
Tan IK, Foong CP, Tan HT et al (2020) Polyhydroxyalkanoate (PHA) synthase genes and PHA-associated gene clusters in Pseudomonas spp. and Janthinobacterium spp. isolated from Antarctica. J Biotechnol 313:18. https://doi.org/10.1016/j.jbiotec.2020.03.006
Tang R, Weng C, Peng X et al (2020) Metabolic engineering of Cupriavidus necator H16 for improved chemoautotrophic growth and PHB production under oxygen-limiting conditions. Metab Eng 61:11. https://doi.org/10.1016/j.ymben.2020.04.009
Ten E, Turtle J, Bahr D (2010) Thermal and mechanical properties of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/cellulose nanowhiskers composites. Polymer 51(12):2652–2660. https://doi.org/10.1016/j.polymer.2010.04.007
Ten E, Jiang L, Wolcott MP (2012) Crystallization kinetics of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/cellulose nanowhiskers composites. Carbohydr Polym 190(1):541–550. https://doi.org/10.1016/j.carbpol.2012.05.076
Thatoi H, Behera BC, Mishra RR et al (2013) Biodiversity and biotechnological potential of microorganisms from mangrove ecosystems: a review. Ann Microbiol 63:1–19. https://doi.org/10.1007/s13213-012-0442-7
Thinagaran L, Sudesh K (2019) Evaluation of sludge palm oil as feedstock and development of efficient method for its utilization to produce polyhydroxyalkanoate. Waste Biomass Valoriz 10(3):709–720. https://doi.org/10.1007/s12649-017-0078-8
Thomas T, Elain A, Bazire A et al (2019) Complete genome sequence of the halophilic PHA-producing bacterium Halomonas sp. SF2003: insights into its biotechnological potential. World J Microbiol Biotechnol 35(3):50. https://doi.org/10.1007/s11274-019-2627-8
Tian J, Sinskey AJ, Stubbe J (2005) Kinetic studies of polyhydroxybutyrate granule formation in Wautersia eutropha H16 by transmission electron microscopy. J Bacteriol 187(11):3814–3824. https://doi.org/10.1128/JB.187.11.3814-3824.2005
Timm AR, Steinbüchel A (1990) Formation of polyesters consisting of medium-chain-length 3-hydroxyalkanoic acids from gluconate by Pseudomonas aeruginosa and other fluorescent pseudomonads. Appl Environ Microbiol 56(11):3360–3367
Troschl C, Meixner K, Drosg B (2017) Cyanobacterial PHA production-review of recent advances and a summary of three years’ working experience running a pilot plant. Bioengineering 4(2):26. https://doi.org/10.3390/bioengineering4020026
Umesh M, Priyanka K, Thazeem B et al (2018) Biogenic PHA nanoparticle synthesis and characterization from Bacillus subtilis NCDC0671 using orange peel medium. Int J Polym Mater Po 67(17):996–1004. https://doi.org/10.1080/00914037.2017.1417284
Urbina L, Eceiza A, Gabilondo N et al (2019) Valorization of apple waste for active packaging: multicomponent polyhydroxyalkanoate coated nanopapers with improved hydrophobicity and antioxidant capacity. Food Packag Shelf Life 21:100356. https://doi.org/10.1016/j.fpsl.2019.100356
Urtuvia V, Maturana N, Peña C et al (2020) Accumulation of poly (3-hydroxybutyrate-co-3-hydroxyvalerate) by Azotobacter vinelandii with different 3HV fraction in shake flasks and bioreactor. Bioprocess Biosyst Eng 43:1469–1478. https://doi.org/10.1007/s00449-020-02340-6
Valappil SP, Boccaccini AR, Bucke C et al (2007) Polyhydroxyalkanoates in Gram-positive bacteria: insights from the genera Bacillus and Streptomyces. Antonie Van Leeuwenhoek 91(1):1–7. https://doi.org/10.1007/s10482-006-9095-5
Valentin HE, Dennis D (1997) Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in recombinant Escherichia coli grown on glucose. J Biotechnol 58:33–38. https://doi.org/10.1016/S0168-1656(97)00127-2
Valentin HE, Steinbüchel A (1995) Accumulation of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid-co-4-hydroxyvaleric acid) by mutants and recombinant strains of Alcaligenes eutrophus. J Environ Polym Degrad 3:169–175. https://doi.org/10.1007/BF02068468
Van Thuoc D, My DN, Loan TT et al (2019) Utilization of waste fish oil and glycerol as carbon sources for polyhydroxyalkanoate production by Salinivibrio sp. M318. Int J Biol Macromol 141:885–892. https://doi.org/10.1016/j.ijbiomac.2019.09.063
Vogel C, Wessel E, Siesler HW (2008) FT-IR imaging spectroscopy of phase separation in blends of poly (3-hydroxybutyrate) with poly (l-lactic acid) and poly (ϵ-caprolactone). Biomacromolecules 9(2):523–527. https://doi.org/10.1021/bm701035p
Volova T, Demidenko A, Kiselev E et al (2019) Polyhydroxyalkanoate synthesis based on glycerol and implementation of the process under conditions of pilot production. Appl Microbiol Biotechnol 103(1):225–237. https://doi.org/10.1007/s00253-018-9460-0
Wang Y, Chen GQ (2017) Polyhydroxyalkanoates: sustainability, production, and industrialization. In: Sustainable polymers from biomass. Wiley, Weiheim. https://doi.org/10.1002/9783527340200.ch2
Wang Q, Nomura CT (2010) Monitoring differences in gene expression levels and polyhydroxyalkanoate (PHA) production in Pseudomonas putida KT2440 grown on different carbon sources. J Biosci Bioeng 110(6):653–659. https://doi.org/10.1016/j.jbiosc.2010.08.001
Wang J, Wang Z, Li J et al (2012) Chitin nanocrystals grafted with poly (3-hydroxybutyrate-co-3-hydroxyvalerate) and their effects on thermal behavior of PHBV. Carbohydr Polym 87(1):784–789. https://doi.org/10.1016/j.carbpol.2011.08.066
Winnacker M (2019) Polyhydroxyalkanoates: recent advances in their synthesis and applications. Eur J Lipid Sci Technol 121(11):1900101. https://doi.org/10.1002/ejlt.201900101
Xiao Z, Zhang Y, Xi L et al (2015) Thermophilic production of polyhydroxyalkanoates by a novel Aneurini bacillus strain isolated from Gudao oilfield, China. J Basic Microbiol 55(9):1125–1133. https://doi.org/10.1002/jobm.201400843
Xie WP, Chen GQ (2008) Production and characterization of terpolyester poly(3-hydroxybutyrate-co-4-hydroxybutyrate-co-3-hydroxyhexanoate) by recombinant Aeromonas hydrophila 4AK4 harboring genes phaPCJ. Biochem Eng J 38:384–389. https://doi.org/10.1016/j.bej.2007.08.002
Xu P, Yang W, Niu D et al (2020) Multifunctional and robust polyhydroxyalkanoate nanocomposites with superior gas barrier, heat resistant and inherent antibacterial performances. Chem Eng J 382:122864. https://doi.org/10.1016/j.cej.2019.122864
Ye J, Hu D, Che X et al (2018) Engineering of Halomonas bluephagenesis for low cost production of poly (3-hydroxybutyrate-co-4-hydroxybutyrate) from glucose. Metab Eng 47:143–152. https://doi.org/10.1016/j.ymben.2018.03.013
Ye J, Hu D, Yin J et al (2020) Stimulus response-based fine-tuning of polyhydroxyalkanoate pathway in Halomonas. Metab Eng 57:85–95. https://doi.org/10.1016/j.ymben.2019.10.007
Yellore VS, Thakur NB, Desai AJ (1999) Enhancement of growth and poly 3-hydroxybutyrate production from Methylobacterium sp. ZP24 by formate and other organic acids. Lett Appl Microbiol 29(3):171–175. https://doi.org/10.1046/j.1365-2672.1999.00608.x
Yezza A, Fournier D, Halasz A et al (2006) Production of polyhydroxyalkanoates from methanol by a new methylotrophic bacterium Methylobacterium sp. GW2. Appl Microbiol Biotechnol 73:211–218. https://doi.org/10.1007/s00253-006-0458-7
Yin F, Li D, Ma X et al (2019) Pretreatment of lignocellulosic feedstock to produce fermentable sugars for poly (3-hydroxybutyrate-co-3-hydroxyvalerate) production using activated sludge. Bioresour Technol 290:121773. https://doi.org/10.1016/j.biortech.2019.121773
Yu W, Lan CH, Wang SJ et al (2010) Influence of zinc oxide nanoparticles on the crystallization behavior of electrospun poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers. Polymer 51(11):2403–2409. https://doi.org/10.1016/j.polymer.2010.03.024
Zare M, Namratha K, Ilyas S et al (2019) Smart fortified PHBV-CS biopolymer with ZnO–Ag nanocomposites for enhanced shelf life of food packaging. ACS Appl Mater 11(51):48309–48320. https://doi.org/10.1021/acsami.9b15724
Zembouai I, Kaci M, Bruzaud S et al (2013) A study of morphological, thermal, rheological and barrier properties of poly (3-hydroxybutyrate-co-3-hydroxyvalerate)/polylactide blends prepared by melt mixing. Polym Test 32(5):842–851. https://doi.org/10.1016/j.polymertesting.2013.04.004
Zhang B, Carlson R, Srienc F (2006) Engineering the monomer composition of polyhydroxyalkanoates synthesized in Saccharomyces cerevisiae. Appl Environ Microbiol 72:536–543. https://doi.org/10.1128/AEM.72.1.536-543.2006
Zhao F, He F, Liu X et al (2020) Metabolic engineering of Pseudomonas mendocina NK-01 for enhanced production of medium-chain-length polyhydroxyalkanoates with enriched content of the dominant monomer. Int J Biol Macromol 154:1596–1605. https://doi.org/10.1016/j.ijbiomac.2019.11.044
Zheng LZ, Li Z, Tian HL, Li M, Chen GQ (2005) Molecular cloning and functional analysis of (R)- 3-hydroxyacyl-acyl carrier protein:coenzyme A transacylase from Pseudomonas mendocina LZ. FEMS Microbiol Lett 252:299–307. https://doi.org/10.1016/j.femsle.2005.09.006
Zúñiga C, Morales M, Le Borgne S et al (2011) Production of poly-β-hydroxybutyrate (PHB) by Methylobacterium organophilum isolated from a methanotrophic consortium in a two-phase partition bioreactor. J Hazard Mater 190(1–3):876–882. https://doi.org/10.1016/j.jhazmat.2011.04.011
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Ojha, N., Das, N. (2021). Microbial Production of Bioplastics: Current Trends and Future Perspectives. In: Kuddus, M., Roohi (eds) Bioplastics for Sustainable Development. Springer, Singapore. https://doi.org/10.1007/978-981-16-1823-9_1
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