Skip to main content
SpringerLink
Log in

Mechanisms of hydroxyapatite formation on porous gel-silica substrates

  • Published:
Journal of Sol-Gel Science and Technology Aims and scope Submit manuscript

Abstract

The variables affecting the nucleation and crystallization of biological hydroxy carbonate apatite (HCA) on porous gel-silica substrates are examined. Texture is the critical variable with the rate of HCA formation increasing as pore size and pore volume increase, with pore sizes >2 nm required to achieve rapid kinetics (4–6 days) of fully crystallized HCA. The concentration of silanol groups on the silica surface does not control the rate of HCA formation although metastable surface defects, such as trisiloxane rings, may be involved in HCA nucleation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L.L.Hench, J. Am. Cer. Soc. 74, 1487 (1991).

    Google Scholar 

  2. L.L.Hench, S.H.Wang, and J.L.Nogues, in Multifunctional Materials, edited by R.L.Gunshor (SPIE, Bellingham, Washington, 1988), Vol. 878, p. 76.

    Google Scholar 

  3. T.Kokubo, S.Ito, Z.T.Huang, T.Hayashi, S.Sakka, T.Kitsugi, and T.Yamamuro, J. Biomed. Mater. Res. 24, 331 and 721–734 (1990).

    Google Scholar 

  4. M.R.Filguerras, G.LaTorre, and L.L.Hench, J. of Biomed. Mat. Res. 27, 1485 (1993).

    Google Scholar 

  5. R.Z.LeGeros, Calcium Phosphates in Oral Biology and Medicine (Karger, Basel, 1991).

    Google Scholar 

  6. P.Li, C.Ohtsuki, T.Kokubo, K.Nakanishi, N.Soga, T.Nakamura, and T.Yamamuro, Materials in Medicine 4, 127 (1993).

    Google Scholar 

  7. P.Li, K.Nakanishi, and K.deGroot, Biomaterials 14, 963 (1993).

    Google Scholar 

  8. P.Li, C.Ohtsuki, T.Kokubo, K.Nakanishi, N.Soga, T.Nakamura, and T.Yamamuro, J. Appl. Biomat. 4, 221 (1993).

    Google Scholar 

  9. M. Pereira, Bioactive Gel-Glasses: Processing and Reaction Mechanisms (Ph.D. Dissertation, University of Florida, 1994).

  10. W.Newman and M.Newman, The Chemical Dynamics of Bone Mineral (University of Chicago, Chicago, Illinois, 1958), p. 34.

    Google Scholar 

  11. C.G.Pantano, A.E.Clark, and L.L.Hench, J. Amer. Ceram. Soc. 57, 412 (1974).

    Google Scholar 

  12. A.E.Clark, C.G.Pantano, and L.L.Hench, J. Amer. Ceram. Soc. 59, 37 (1976).

    Google Scholar 

  13. L.L.Hench and E.C.Ethridge, Biomaterials: An Interfacial Approach (Academic Press, New York, 1982).

    Google Scholar 

  14. C.Y.Kim, A.E.Clark, and L.L.Hench, J. Non. Cryst. Solids 113, 195 (1989).

    Google Scholar 

  15. O.H.Andersson, K.H.Karlsson, and K.Kangesniemi, J. Non. Cryst. Solids 119, 290 (1990).

    Google Scholar 

  16. W.Holand, W.Vogel, K.Naumann, and J.Gummel, J. Biomed. Mater. Res. 19, 303 (1985).

    Google Scholar 

  17. C.Ohtsuki, H.Kushitani, T.Kokubo, S.Kotani, and T.Yamamuro, J. Biomed. Mater. Res. 25, 1363 (1991).

    Google Scholar 

  18. T.Kitsugi, T.Nakamuro, T.Yamamuro, T.Kokubo, T.Shibuya, and M.Takagi, J. Biomed. Mater. Res. 21, 1255 (1987).

    Google Scholar 

  19. M.Neo, S.Kotani, T.Nakamura, T.Yamamuro, C.Ohtsuki, T.Kokubo, and Y.Bando, J. Biomed. Mater. Res. 26, 1419 (1992).

    Google Scholar 

  20. T.Kokubo, in Introduction to Bioceramics, edited by L.L.Hench and J.Wilson (World Scientific Publishing Co., Singapore, 1993), p. 75.

    Google Scholar 

  21. R.K.Iler, The Chemistry of Silica (John Wiley & Sons, New York, 1979).

    Google Scholar 

  22. J.J.M.Damen and J.M.Cate, J. Dent, Res. 68, 1355 (1989).

    Google Scholar 

  23. J.J.M.Damen and J.M.Cate, J. Dent. Res. 71, 453 (1992).

    Google Scholar 

  24. J.Adair, T.Nagira, C.M.Brown, S.R.Khan, and W.C.ThomasJr., in Urolithiasis 2 edited by R.Ryall (Plenum Press, New York, 1993).

    Google Scholar 

  25. P.Li, C.Ohtsuki, T.Kokubo, K.Nakanish, N.Soga, T.Nakamura, and T.Yamamuro, J. Amer. Ceram. Soc. 75, 2094 (1992).

    Google Scholar 

  26. M.M. Walker, An Investigation into the Bonding Mechanisms of Bioglass (M.S. Thesis, University of Florida, 1977).

  27. P.Li and F.Zhang, J. Non. Cryst. Solids 119, 112 (1990).

    Google Scholar 

  28. P.Li and K.deGroot, J. Biomed. Mater. Res. 27, 1495 (1993).

    Google Scholar 

  29. P. Li, In Vitro and In Vivo Calcium Phosphate Induction on Gel Oxides (Ph.D. Dissertation, Leiden University, 1993).

  30. P.Li, C.Ohtsuki, T.Kokubo, K.Nakanish, N.Soga, and K.deGroot, J. Biomed. Mater. Res. 28, 7 (1994).

    Google Scholar 

  31. G.A.Parks, Chem. Rev. 65, 177 (1965).

    Google Scholar 

  32. J.P.Zhong, G.P.LaTorre, and D.Greenspan, in Bioceramics 8, edited by L.L.Hench and D.Greenspan (Elsevier Publishing Co., Oxford, 1995).

    Google Scholar 

  33. M.Krukowski, R.A.Shively, P.Osbody, and B.L.Eppley, J. Oral Maxillofac. Surg. 48, 468 (1990).

    Google Scholar 

  34. E.Banks, S.Nakajima, L.C.Shapiro, O.Tilevitz, J.R.Alonzo, and C.Chianelli, Science 198, 1164 (1977).

    Google Scholar 

  35. J.P.Zhong, G.P.LaTorre, and L.L.Hench, in Bioceramics 7, edited by Ö.H.Andersson and A.Yli-Urpo (Butterworth-Heinemann Ltd., Oxford, 1994) p. 61.

    Google Scholar 

  36. M. Pereira and L.L. Hench, J. Am. Ceram. Soc. (1995) (In Press).

  37. L.T.Zhuravlev, Langmuir 3, 316 (1987).

    Google Scholar 

  38. L.L.Hench, O.A.Andersson, and G.P.LaTorre, in Bioceramics 4, edited by W.Bonfield, G.W.Hastings, and K.E.Tanner (Butterworth-Heinemann Ltd., Guildford, London, 1991), p. 155.

    Google Scholar 

  39. R.Li, A.E.Clark, and L.L.Hench, J. Ap. Biomater. 2, 231 (1991).

    Google Scholar 

  40. J.K.West and L.L.Hench, in Bioceramics 5, edited by T.Yamamuro, T.Kokubo, and T.Nakamura (Kobunshi Kankokai, Japan, 1992), p. 75.

    Google Scholar 

  41. S.Wallace, J.K.West, and L.L.Hench, J.Non, Cryst. Solids 152, 101 (1993).

    Google Scholar 

  42. C.J.Brinker and G.W.Scherer, Sol-Gel Science (Academic Press, New York, 1990).

    Google Scholar 

  43. C.J.Young, J. Colloid Sci. 13, 67 (1958).

    Google Scholar 

  44. C.Bunker, D.M.Haaland, T.A.Michalske, and W.L.Smith, Surface Sci. 222, 95 (1989).

    Google Scholar 

  45. K.H.Karlsson, K.Froberg, and T.Ringbom, J. Non. Cryst. Solids 112, 69 (1989).

    Google Scholar 

  46. T.Kokubo, S.B.Cho, K.Nakanishi, N.Soga, C.Ohtsuki, T.Kitsugi, T.Yamamuro, and T.Nakamura, in Bioceramics 7, edited by Ö.H.Andersson and A.Yli-Urpo (Butterworth-Heinemann Ltd., Oxford, 1994), p. 49.

    Google Scholar 

  47. A.E.Clark, C.Y.Kim, J.West, J.Wilson, and L.L.Hench, in Handbook of Bioactive Ceramics 1, edited by T.Yamamuro, L.L.Hench, and J.Wilson (CRC Press, Boca Raton, 1990), p. 73.

    Google Scholar 

Download references

Authors
  1. Marivalda M. Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Larry L. Hench
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pereira, M.M., Hench, L.L. Mechanisms of hydroxyapatite formation on porous gel-silica substrates. J Sol-Gel Sci Technol 7, 59–68 (1996). https://doi.org/10.1007/BF00401884

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00401884

Keywords

Search

Navigation