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2D material–based peroxidase-mimicking nanozymes: catalytic mechanisms and bioapplications

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Abstract

The boom in nanotechnology brings new insights into the development of artificial enzymes (nanozymes) with ease of modification, lower manufacturing cost, and higher catalytic stability than natural enzymes. Among various nanomaterials, two-dimensional (2D) nanomaterials exhibit promising enzyme-like properties for a plethora of bioapplications owing to their unique physicochemical characteristics of tuneable composition, ultrathin thickness, and huge specific surface area. Herein, we review the recent advances in several 2D material–based nanozymes, such as carbonaceous nanosheets, metal–organic frameworks (MOFs), transition metal dichalcogenides (TMDs), layered double hydroxides (LDHs), and transition metal oxides (TMOs), clarify the mechanisms of peroxidase (POD)-mimicking catalytic behaviors, and overview the potential bioapplications of 2D nanozymes.

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Funding

This work was supported by the National Natural Science Foundation of China (No. 21975123) and the Six Talent Peaks Project in Jiangsu Province (No. XCL-024).

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  1. Jia Yang, Henghan Dai, and Yue Sun are contributed equally in this work.

Authors and Affiliations

  1. School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, 454003, China

    Jia Yang, Gang Qin & Gengzhi Sun

  2. Institute of Advanced Materials, Nanjing Tech University, Nanjing, 211816, China

    Henghan Dai, Yue Sun, Lumin Wang & Gengzhi Sun

  3. School of Physical Science and Technology, Lanzhou University, Lanzhou, 730000, China

    Jinyuan Zhou

  4. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 352001, China

    Qiang Chen

  5. Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, 325000, China

    Qiang Chen

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  1. Jia Yang
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Yang, J., Dai, H., Sun, Y. et al. 2D material–based peroxidase-mimicking nanozymes: catalytic mechanisms and bioapplications. Anal Bioanal Chem 414, 2971–2989 (2022). https://doi.org/10.1007/s00216-022-03985-w

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