Abstract
One of the most common indications for performing magnetic resonance (MR) imaging of the lumbar spine is the symptom complex thought to originate as a result of degenerative disk disease. MR imaging, which has emerged as perhaps the modality of choice for imaging degenerative disk disease, can readily demonstrate disk pathology, degenerative endplate changes, facet and ligamentous hypertrophic changes, and the sequelae of instability. Its role in terms of predicting natural history of low back pain, identifying causality, or offering prognostic information is unclear. As available modalities for imaging the spine have progressed from radiography, myelography, and computed tomography to MR imaging, there have also been advances in spine surgery for degenerative disk disease. These advances are described in a temporal context for historical purposes with a focus on MR imaging’s history and current state.
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Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS. Magnetic resonance imaging of the lumbar spine in people without back pain. N Engl J Med. 1994;331(2):69–73.
Borenstein DG, O'Mara Jr JW, Boden SD, Lauerman WC, Jacobson A, Platenberg C, et al. The value of magnetic resonance imaging of the lumbar spine to predict low-back pain in asymptomatic subjects: a seven-year follow-up study. J Bone Joint Surg. 2001;83-A(9):1306–11.
Andersson GB. Epidemiological features of chronic low-back pain. Lancet. 1999;354(9178):581–5.
Deyo RA. Early diagnostic evaluation of low back pain. J Gen Intern Med. 1986;1(5):328–38.
Deyo RA, Rainville J, Kent DL. What can the history and physical examination tell us about low back pain? JAMA. 1992;268(6):760–5.
Hart LG, Deyo RA, Cherkin DC. Physician office visits for low back pain. Frequency, clinical evaluation, and treatment patterns from a U.S. national survey. Spine. 1995;20(1):11–9.
Martin BI, Deyo RA, Mirza SK, Turner JA, Comstock BA, Hollingworth W, et al. Expenditures and health status among adults with back and neck problems. JAMA. 2008;299(6):656–64.
Coste J, Delecoeuillerie G, Cohende Lara A, Le Parc JM, Paolaggi JB. Clinical course and prognostic factors in acute low back pain: an inception cohort study in primary care practice. BMJ. 1994;308(6928):577–80.
Cherkin DC, Deyo RA, Street JH, Barlow W. Predicting poor outcomes for back pain seen in primary care using patients' own criteria. Spine. 1996;21(24):2900–7.
Croft PR, Macfarlane GJ, Papageorgiou AC, Thomas E, Silman AJ. Outcome of low back pain in general practice: a prospective study. BMJ. 1998;316(7141):1356–9.
Bozzao A, Gallucci M, Masciocchi C, Aprile I, Barile A, Passariello R. Lumbar disk herniation: MR imaging assessment of natural history in patients treated without surgery. Radiology. 1992;185(1):135–41.
Delauche-Cavallier MC, Budet C, Laredo JD, Debie B, Wybier M, Dorfmann H, et al. Lumbar disc herniation. Computed tomography scan changes after conservative treatment of nerve root compression. Spine. 1992;17(8):927–33.
Johnsson KE, Rosen I, Uden A. The natural course of lumbar spinal stenosis. Clin Orthop Relat Res. 1992;279:82–6.
Weiner DK, Kim YS, Bonino P, Wang T. Low back pain in older adults: are we utilizing healthcare resources wisely? Pain Med. 2006;7(2):143–50.
Chou R, Qaseem A, Snow V, Casey D, Cross Jr JT, Shekelle P, et al. Diagnosis and treatment of low back pain: a joint clinical practice guideline from the American College of Physicians and the American Pain Society. Ann Intern Med. 2007;147(7):478–91.
Modic MT, Ross JS. Lumbar degenerative disk disease. Radiology. 2007;245(1):43–61.
Dewing S. Modern radiology in historical perspective. Springfield, IL: Thomas; 1962.
Davis A. Fractures of the spine. J Bone Joint Surg. 1929;11:133–56.
Andrews J. Planigraphy: introduction and history. AJR Am J Roentgenol Am J Roentgenol. 1936;36:575–87.
Jacobeus H. On insufflation of air into the spinal canal for diagnostic purposes in cases of the spinal cord. Acta Med Scand. 1921;21:555–60.
Dandy W. Diagnosis and localization of cord tumors. Ann Surg. 1925;46:463–8.
Sicard JJF. Methode generale d'exploration radiologique par l'huite iodee (Lipidiole). Ann Méd Interne. 1922;46:463–8.
Ramsey G, French J, Strain W. Iodinated organic compounds as contrast media for radiographic diagnoses. IV. Pantopaque myelography. Radiology. 1944;43:236–40.
Peterson HO. The hazards of myelography. Radiology. 1975;115(1):237–9.
Arnell S, Lidstrom F. Myelography with Skiodan (abrodil). Acta Radiol. 1931;12:287–9.
Sackett JF, Strother CM, Quaglieri CE, Javid MJ, Levin AB, Duff TA. Metrizamide–CSF contrast medium. Analysis of clinical application in 215 patients. Radiology. 1977;123(3):779–82.
Eldevik OP, Nakstad P, Kendall BE, Hindmarsh T. Iohexol in lumbar myelography: preliminary results from an open, noncomparative multicenter clinical study. AJNR Am J Neuroradiol Am J Neuroradiol. 1983;4(3):299–301.
Witwer G, Cacayorin ED, Bernstein AD, Hubballah MY, Yuan HA, Kieffer SA. Iopamidol and metrizamide for myelography: prospective double-blind clinical trial. AJR Am J Roentgenol. 1984;143(4):869–73.
Lindblom K. Discography of dissecting transosseous rupture of disks in lumbar region. Acta Radiol. 1951;36:12–6.
Gargano F, Meyer J, Sheldon J. Transfemoral ascending lumbar catheterization of the epidural veins in lumbar disk disease. Radiology. 1974;111:329–36.
Djindjian R. Arteriography of the spinal cord. AJR Am J Roentgenol. 1969;107:461–78.
Di Chiro G, Schellinger D. Computed tomography of spinal cord after lumbar intrathecal introduction of metrizamide (computer-assisted myelography). Radiology. 1976;120(1):101–4.
Knoeller SM, Seifried C. Historical perspective: history of spinal surgery. Spine. 2000;25(21):2838–43.
Kocher T. Die Verletzungen der Wirbelsaule zugleich als Beitrag zur Physiologies des menschlichen Ruckenmarks. Mitt Grenzgeb Med Chir. 1896;1:415–80.
Keller T, Holland MC. Some notable American spine surgeons of the 19th century. Spine. 1997;22(12):1413–7.
Patwardhan RV, Hadley MN. History of surgery for ruptured disk. Neurosurg Clin N Am. 2001;12(1):173–9. x.
Robinson J. Sciatica and the lumbar disk syndrome: a historic perspective. South Med J. 1983;76:232–8.
Schmorl G. Über die pathologische Anatomie der Wirbelbandscheiben. Beitr Klin Chir. 1931;151:360–8.
Dandy W. Loose cartilage from intervertebral disk simulating tumor of the spinal cord. Arch Surg. 1929;19:660–72.
Mixter W, Barr J. Rupture of the intervertebral disc with involvement of the spinal canal. N Engl J Med. 1934;211.
Verbiest H. Results of surgical treatment of idiopathic developmental stenosis of the lumbar vertebral canal. A review of twenty-seven years' experience. J Bone Joint Surg Br. 1977;59(2):181–8.
Harrington PR, Dickson JH. Spinal instrumentation in the treatment of severe progressive spondylolisthesis. Clin Orthop Relat Res. 1976;117:157–63.
Ransohoff J, Spencer F, Siew F, Gage L Jr. Transthoracic removal of thoracic disc. Report of three cases. J Neurosurg. 1969;31(4):459–61.
Harrington PR. The history and development of Harrington instrumentation. Clin Orthop Relat Res. 1973;93:110–2.
Hijikata S. Percutaneous nucleotomy. A new concept technique and 12 years’ experience. Clin Orthop Relat Res. 1989;238:9–23.
Freebody D, Bendall R, Taylor RD. Anterior transperitoneal lumbar fusion. J Bone Joint Surg Br. 1971;53(4):617–27.
Denis F. The three column spine and its significance in the classification of acute thoracolumbar spinal injuries. Spine. 1983;8(8):817–31.
Cotrel Y, Dubousset J, Guillaumat M. New universal instrumentation in spinal surgery. Clin Orthop Relat Res. 1988;227:10–23.
Louis R. Fusion of the lumbar and sacral spine by internal fixation with screw plates. Clin Orthop Relat Res. 1986;203:18–33.
Luque ER. The anatomic basis and development of segmental spinal instrumentation. Spine. 1982;7(3):256–9.
Luque ER. Interpeduncular segmental fixation. Clin Orthop Relat Res. 1986;203:54–7.
Modic MT, Pavlicek W, Weinstein MA, Boumphrey F, Ngo F, Hardy R, et al. Magnetic resonance imaging of intervertebral disk disease. Clinical and pulse sequence considerations. Radiology. 1984;152(1):103–11.
Edelman RR, Shoukimas GM, Stark DD, Davis KR, New PF, Saini S, et al. High-resolution surface-coil imaging of lumbar disk disease. AJR Am J Roentgenol. 1985;144(6):1123–9.
Mansfield P. Multi-planar image formation using NMR spin-echos. J Phys C Solid State Physics. 1977;10:L55–8.
Haase A, Frahm J, Matthaei D, Hanicke W, Merboldt K. FLASH imaging. Rapid NMR imaging using low flip-angle pulses. J Magn Reson Imaging. 1986;67:258–66.
Hennig J, Nauerth A, Friedburg H. RARE imaging: a fast imaging method for clinical MR. Magn Reson Med. 1986;3(6):823–33.
Mulkern RV, Wong ST, Winalski C, Jolesz FA. Contrast manipulation and artifact assessment of 2D and 3D RARE sequences. Magn Reson Imaging. 1990;8(5):557–66.
Dwyer AJ, Frank JA, Sank VJ, Reinig JW, Hickey AM, Doppman JL. Short-Ti inversion-recovery pulse sequence: analysis and initial experience in cancer imaging. Radiology. 1988;168(3):827–36.
Ross JS. Newer sequences for spinal MR imaging: smorgasbord or succotash of acronyms? AJNR Am J Neuroradiol. 1999;20(3):361–73.
Hayes CE, Edelstein WA, Schenck J, Mueller O, Eash M. An efficient, highly homogenous radiofrequency coil for whole-body NMR imaging at 1.5 T. J Magn Reson Imaging. 1985;63:622–8.
Roemer PB, Edelstein WA, Hayes CE, Souza SP, Mueller OM. The NMR phased array. Magn Reson Med. 1990;16(2):192–225.
Roemer PB, Edelstein WA. Self-shielded gradient coils (abstract). In: Proceedings of the 5th annual conference, Society of Magnetic Resonance in Medicine, Montreal, Quebec, Canada; 1986.
Riederer SJ. MR imaging: its development and the recent Nobel Prize. Radiology. 2004;231(3):628–31.
Norman D, Mills CM, Brant-Zawadzki M, Yeates A, Crooks LE, Kaufman L. Magnetic resonance imaging of the spinal cord and canal: potentials and limitations. AJR Am J Roentgenol. 1983;141(6):1147–52.
Maravilla KR, Lesh P, Weinreb JC, Selby DK, Mooney V. Magnetic resonance imaging of the lumbar spine with CT correlation. AJNR Am J Neuroradiol. 1985;6(2):237–45.
Yu SW, Sether LA, Ho PS, Wagner M, Haughton VM. Tears of the anulus fibrosus: correlation between MR and pathologic findings in cadavers. AJNR Am J Neuroradiol. 1988;9(2):367–70.
Bergstrom K, Nyberg G, Pech P, Rauschning W, Ytterbergh C. Multiplanar spinal anatomy: comparison of CT and cryomicrotomy in postmortem specimens. AJNR Am J Neuroradiol. 1983;4(3):590–2.
Nowicki BH, Haughton VM, Schmidt TA, Lim TH, An HS, Riley LH 3rd, et al. Occult lumbar lateral spinal stenosis in neural foramina subjected to physiologic loading. AJNR Am J Neuroradiol. 1996;17(9):1605–14.
Hueftle MG, Modic MT, Ross JS, Masaryk TJ, Carter JR, Wilber RG, et al. Lumbar spine: postoperative MR imaging with Gd-DTPA. Radiology. 1988;167(3):817–24.
Crisi G, Carpeggiani P, Trevisan C. Gadolinium-enhanced nerve roots in lumbar disk herniation. AJNR Am J Neuroradiol. 1993;14(6):1379–92.
Lane JI, Koeller KK, Atkinson JL. Enhanced lumbar nerve roots in the spine without prior surgery: radiculitis or radicular veins? AJNR Am J Neuroradiol. 1994;15(7):1317–25.
Ross JS, Blaser S, Masaryk TJ, Emory SE, Bolesta M, Carter J, et al. Gd-DTPA enhancement of posterior epidural scar: an experimental model. AJNR Am J Neuroradiol. 1989;10(5):1083–8.
Ross JS, Delamarter R, Hueftle MG, Masaryk TJ, Aikawa M, Carter J, et al. Gadolinium-DTPA-enhanced MR imaging of the postoperative lumbar spine: time course and mechanism of enhancement. AJR Am J Roentgenol. 1989;152(4):825–34.
Ross JS, Masaryk TJ, Schrader M, Gentili A, Bohlman H, Modic MT. MR imaging of the postoperative lumbar spine: assessment with gadopentetate dimeglumine. AJNR Am J Neuroradiol. 1990;11(4):771–6.
Hiwatashi A, Danielson B, Moritani T, Bakos RS, Rodenhause TG, Pilcher WH, et al. Axial loading during MR imaging can influence treatment decision for symptomatic spinal stenosis. AJNR Am J Neuroradiol. 2004;25(2):170–4.
Maravilla KR, Bowen BC. Imaging of the peripheral nervous system: evaluation of peripheral neuropathy and plexopathy. AJNR Am J Neuroradiol. 1998;19(6):1011–23.
Antoniou J, Demers CN, Beaudoin G, Goswami T, Mwale F, Aebi M, et al. Apparent diffusion coefficient of intervertebral discs related to matrix composition and integrity. Magn Reson Imaging. 2004;22(7):963–72.
Chiu EJ, Newitt DC, Segal MR, Hu SS, Lotz JC, Majumdar S. Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro. Spine. 2001;26(19):E437–44.
Haughton V. Medical imaging of intervertebral disc degeneration: current status of imaging. Spine. 2004;29(23):2751–6.
Hsu EW, Setton LA. Diffusion tensor microscopy of the intervertebral disc anulus fibrosus. Magn Reson Med. 1999;41(5):992–9.
Resnick DK, Niwayama G. Degenerative disease of the spine. Philadelphia, PA: Saunders; 1995.
Nathan H. Osteophytes of the vertebral column: an anatomical study of their development according to age, race, and sex with considerations as to their etiology and significance. J Bone Joint Surg. 1962;44:243–68.
Adams MA, Freeman BJ, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. 2000;25(13):1625–36.
Hurri H, Karppinen J. Discogenic pain. Pain. 2004;112(3):225–8.
Kresina TF, Malemud CJ, Moskowitz RW. Analysis of osteoarthritic cartilage using monoclonal antibodies reactive with rabbit proteoglycan. Arthritis Rheum. 1986;29(7):863–71.
Battie MC, Videman T, Gibbons LE, Fisher LD, Manninen H, Gill K. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine. 1995;20(24):2601–12.
Hestbaek L, Iachine IA, Leboeuf-Yde C, Kyvik KO, Manniche C. Heredity of low back pain in a young population: a classical twin study. Twin Res. 2004;7(1):16–26.
Majors A, McDevitt C, Sigalis I, Modic MT. A correlative analysis of T2, ADC and MT ratio with water, hydroxyproline and GAG content in excised intervertebral disk. In: Proceedings of the 40th annualmeeting, Orthopaedic Research Society, New Orleans, LA; 1994.
Coventry MB. Anatomy of the intervertebral disk. Clin Orthop Relat Res. 1969;67:9–15.
Friberg S, Hirsch C. Anatomical and clinical studies on lumbar disc degeneration. Acta Orthop Scand. 1949;19(2):222–42. illust.
Hirsch C. Studies on the pathology of low back pain. J Bone Joint Surg Br. 1959;41-B(2):237–43.
Sether LA, Yu S, Haughton VM, Fischer ME. Intervertebral disk: normal age-related changes in MR signal intensity. Radiology. 1990;177(2):385–8.
Yu S, Haughton VM, Sether LA, Ho KC, Wagner M. Criteria for classifying normal and degenerated lumbar intervertebral disks. Radiology. 1989;170(2):523–6.
Knutsson F. The vacuum phenomenon in the intervertebral discs. Acta Radiol. 1942;23:173–9.
Bangert BA, Modic MT, Ross JS, Obuchowski NA, Perl J, Ruggieri PM, et al. Hyperintense disks on T1-weighted MR images: correlation with calcification. Radiology. 1995;195(2):437–43.
Frobin W, Brinckmann P, Kramer M, Hartwig E. Height of lumbar discs measured from radiographs compared with degeneration and height classified from MR images. Eur Radiol. 2001;11(2):263–9.
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26(17):1873–8.
de Roos A, Kressel H, Spritzer C, Dalinka M. MR imaging of marrow changes adjacent to end plates in degenerative lumbar disk disease. AJR Am J Roentgenol. 1987;149(3):531–4.
Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR. Degenerative disk disease: assessment of changes in vertebral body marrow with MR imaging. Radiology. 1988;166(1 Pt 1):193–9.
Ross JS, Zepp R, Modic MT. The postoperative lumbar spine: enhanced MR evaluation of the intervertebral disk. AJNR Am J Neuroradiol. 1996;17(2):323–31.
Ross JS, Robertson JT, Frederickson RC, Petrie JL, Obuchowski N, Modic MT, et al. Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group. Neurosurgery. 1996;38(4):855–61, discussion 861–3.
Morrison JL, Kaplan PA, Dussault RG, Anderson MW. Pedicle marrow signal intensity changes in the lumbar spine: a manifestation of facet degenerative joint disease. Skeletal Radiol. 2000;29(12):703–7.
Ulmer JL, Elster AD, Mathews VP, Allen AM. Lumbar spondylolysis: reactive marrow changes seen in adjacent pedicles on MR images. AJR Am J Roentgenol. 1995;164(2):429–33.
Jones A, Clarke A, Freeman BJ, Lam KS, Grevitt MP. The Modic classification: inter- and intraobserver error in clinical practice. Spine. 2005;30(16):1867–9.
Schellinger D, Wener L, Ragsdale BD, Patronas NJ. Facet joint disorders and their role in the production of back pain and sciatica. Radiographics. 1987;7(5):923–44.
Doyle AJ, Merrilees M. Synovial cysts of the lumbar facet joints in a symptomatic population: prevalence on magnetic resonance imaging. Spine. 2004;29(8):874–8.
Baastrup C. On the spinous processes of the lumbar vertebrae and the soft tissue between them and on pathological changes in that region. Acta Radiol Scan. 1933;14:52–4.
Fardon DF, Milette PC. Nomenclature and classification of lumbar disc pathology. Recommendations of the combined task forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology. Spine. 2001;26(5):E93–113.
Wiltse LL, Berger PE, McCulloch JA. A system for reporting the size and location of lesions in the spine. Spine. 1997;22(13):1534–7.
Jarvik JG, Deyo RA. Diagnostic evaluation of low back pain with emphasis on imaging. Ann Intern Med. 2002;137(7):586–97.
Carrino JA, Lurie JD, Tosteson AN, Tosteson TD, Carragee EJ, Kaiser J, et al. Lumbar spine: reliability of MR imaging findings. Radiology. 2009;250(1):161–70.
Arana E, Royuela A, Kovacs FM, Estremera A, Sarasibar H, Amengual G, et al. Lumbar spine: agreement in the interpretation of 1.5-T MR images by using the Nordic Modic Consensus Group classification form. Radiology. 254(3):809–17.
Lurie JD, Doman DM, Spratt KF, Tosteson AN, Weinstein JN. Magnetic resonance imaging interpretation in patients with symptomatic lumbar spine disc herniations: comparison of clinician and radiologist readings. Spine. 2009;34(7):701–5.
Arnoldi CC, Brodsky AE, Cauchoix J, Crock HV, Dommisse GF, Edgar MA, et al. Lumbar spinal stenosis and nerve root entrapment syndromes. Definition and classification. Clin Orthop Relat Res. 1976;115:4–5.
Amundsen T, Weber H, Lilleas F, Nordal HJ, Abdelnoor M, Magnaes B. Lumbar spinal stenosis. Clinical and radiologic features. Spine. 1995;20(10):1178–86.
Inufusa A, An HS, Lim TH, Hasegawa T, Haughton VM, Nowicki BH. Anatomic changes of the spinal canal and intervertebral foramen associated with flexion-extension movement. Spine. 1996;21(21):2412–20.
Van Goethem JW, Parizel PM, van den Hauwe L, De Schepper AM. Imaging findings in patients with failed back surgery syndrome. J Belge Radiol. 1997;80(2):81–4.
Van Goethem JW, Parizel PM, Jinkins JR. Review article: MRI of the postoperative lumbar spine. Neuroradiology. 2002;44(9):723–39.
Cervellini P, Curri D, Volpin L, Bernardi L, Pinna V, Benedetti A. Computed tomography of epidural fibrosis after discectomy: a comparison between symptomatic and asymptomatic patients. Neurosurgery. 1988;23(6):710–3.
Coskun E, Suzer T, Topuz O, Zencir M, Pakdemirli E, Tahta K. Relationships between epidural fibrosis, pain, disability, and psychological factors after lumbar disc surgery. Eur Spine J. 2000;9(3):218–23.
North RB, Campbell JN, James CS, Conover-Walker MK, Wang H, Piantadosi S, et al. Failed back surgery syndrome: 5-year follow-up in 102 patients undergoing repeated operation. Neurosurgery. 1991;28(5):685–90, discussion 690–1.
Hurme M, Katevuo K, Nykvist F, Aalto T, Alaranta H, Einola S. CT five years after myelographic diagnosis of lumbar disk herniation. Acta Radiol. 1991;32(4):286–9.
Olmarker K, Rydevik B. Pathophysiology of sciatica. Orthop Clin North Am. 1991;22(2):223–34.
Sunderland S. Nerves and nerve injuries, 2nd ed. Edinburgh: Churchill Livingstone; 1978.
Van Goethem JW, Van de Kelft E, Biltjes IG, van Hasselt BA, van den Hauwe L, Parizel PM, et al. MRI after successful lumbar discectomy. Neuroradiology. 1996;38 Suppl 1:S90–6.
Ross JS, Obuchowski N, Zepp R. The postoperative lumbar spine: evaluation of epidural scar over a 1-year period. AJNR Am J Neuroradiol. 1998;19(1):183–6.
Lee YS, Choi ES, Song CJ. Symptomatic nerve root changes on contrast-enhanced MR imaging after surgery for lumbar disk herniation. AJNR Am J Neuroradiol. 2009;30(5):1062–7.
Hitselberger WE, Witten RM. Abnormal myelograms in asymptomatic patients. J Neurosurg. 1968;28(3):204–6.
Wiesel SW, Tsourmas N, Feffer HL, Citrin CM, Patronas N. A study of computer-assisted tomography. I. The incidence of positive CAT scans in an asymptomatic group of patients. Spine. 1984;9(6):549–51.
Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation. J Bone Joint Surg. 1990;72(3):403–8.
Modic MT, Ross JS, Obuchowski NA, Browning KH, Cianflocco AJ, Mazanec DJ. Contrast-enhanced MR imaging in acute lumbar radiculopathy: a pilot study of the natural history. Radiology. 1995;195(2):429–35.
Saal JA, Saal JS, Herzog RJ. The natural history of lumbar intervertebral disc extrusions treated nonoperatively. Spine. 1990;15(7):683–6.
Modic MT, Obuchowski NA, Ross JS, Brant-Zawadzki MN, Grooff PN, Mazanec DJ, et al. Acute low back pain and radiculopathy: MR imaging findings and their prognostic role and effect on outcome. Radiology. 2005;237(2):597–604.
Elfering A, Semmer N, Birkhofer D, Zanetti M, Hodler J, Boos N. Risk factors for lumbar disc degeneration: a 5-year prospective MRI study in asymptomatic individuals. Spine. 2002;27(2):125–34.
Carragee EJ, Alamin TF, Miller JL, Carragee JM. Discographic, MRI and psychosocial determinants of low back pain disability and remission: a prospective study in subjects with benign persistent back pain. Spine J. 2005;5(1):24–35.
Carragee E, Alamin T, Cheng I, Franklin T, van den Haak E, Hurwitz E. Are first-time episodes of serious LBP associated with new MRI findings? Spine J. 2006;6(6):624–35.
Benoist M. The natural history of lumbar degenerative spinal stenosis. Joint Bone Spine. 2002;69(5):450–7.
Carragee EJ, Kim DH. A prospective analysis of magnetic resonance imaging findings in patients with sciatica and lumbar disc herniation. Correlation of outcomes with disc fragment and canal morphology. Spine. 1997;22(14):1650–60.
Takada E, Takahashi M, Shimada K. Natural history of lumbar disc hernia with radicular leg pain: spontaneous MRI changes of the herniated mass and correlation with clinical outcome. J Orthop Surg (Hong Kong). 2001;9(1):1–7.
Komori H, Shinomiya K, Nakai O, Yamaura I, Takeda S, Furuya K. The natural history of herniated nucleus pulposus with radiculopathy. Spine. 1996;21(2):225–9.
Yukawa Y, Kato F, Matsubara Y, Kajino G, Nakamura S, Nitta H. Serial magnetic resonance imaging follow-up study of lumbar disc herniation conservatively treated for average 30 months: relation between reduction of herniation and degeneration of disc. J Spinal Disord. 1996;9(3):251–6.
Jensen TS, Albert HB, Sorensen JS, Manniche C, Leboeuf-Yde C. Magnetic resonance imaging findings as predictors of clinical outcome in patients with sciatica receiving active conservative treatment. J Manipulative Physiol Ther. 2007;30(2):98–108.
Komori H, Okawa A, Haro H, Shinomiya Ki K. Factors predicting the prognosis of lumbar radiculopathy due to disc herniation. J Orthop Sci. 2002;7(1):56–61.
Vroomen PC, Wilmink JT, de KM. Prognostic value of MRI findings in sciatica. Neuroradiology. 2002;44(1):59–63.
Beattie PF, Meyers SP, Stratford P, Millard RW, Hollenberg GM. Associations between patient report of symptoms and anatomic impairment visible on lumbar magnetic resonance imaging. Spine. 2000;25(7):819–28.
Jarvik JJ, Hollingworth W, Heagerty P, Haynor DR, Deyo RA. The Longitudinal Assessment of Imaging and Disability of the Back (LAIDBack) Study: baseline data. Spine. 2001;26(10):1158–66.
Kjaer P, Korsholm L, Bendix T, Sorensen JS, Leboeuf-Yde C. Modic changes and their associations with clinical findings. Eur Spine J. 2006;15(9):1312–9.
Jarvik JG, Hollingworth W, Heagerty PJ, Haynor DR, Boyko EJ, Deyo RA. Three-year incidence of low back pain in an initially asymptomatic cohort: clinical and imaging risk factors. Spine. 2005;30(13):1541–8, discussion 1549.
Esposito P, Pinheiro-Franco JL, Froelich S, Maitrot D. Predictive value of MRI vertebral end-plate signal changes (Modic) on outcome of surgically treated degenerative disc disease. Results of a cohort study including 60 patients. Neuro Chirurgie. 2006;52(4):315–22.
Vital JM, Gille O, Pointillart V, Pedram M, Bacon P, Razanabola F, et al. Course of Modic 1 six months after lumbar posterior osteosynthesis. Spine. 2003;28(7):715–20, discussion 721.
Chou R, Fu R, Carrino JA, Deyo RA. Imaging strategies for low-back pain: systematic review and meta-analysis. Lancet. 2009;373(9662):463–72.
Jarvik JG, Hollingworth W, Martin B, Emerson SS, Gray DT, Overman S, et al. Rapid magnetic resonance imaging vs radiographs for patients with low back pain: a randomized controlled trial. JAMA. 2003;289(21):2810–8.
Kerry S, Hilton S, Dundas D, Rink E, Oakeshott P. Radiography for low back pain: a randomised controlled trial and observational study in primary care. Br J Gen Pract. 2002;52(479):469–74.
Lurie JD, Birkmeyer NJ, Weinstein JN. Rates of advanced spinal imaging and spine surgery. Spine. 2003;28(6):616–20.
Errico TJ, Fardon DF, Lowell TD. Open discectomy as treatment for herniated nucleus pulposus of the lumbar spine. Spine. 1995;20(16):1829–33.
Keller RB, Atlas SJ, Soule DN, Singer DE, Deyo RA. Relationship between rates and outcomes of operative treatment for lumbar disc herniation and spinal stenosis. J Bone Joint Surg. 1999;81(6):752–62.
Ash LM, Modic MT, Obuchowski NA, Ross JS, Brant-Zawadzki MN, Grooff PN. Effects of diagnostic information, per se, on patient outcomes in acute radiculopathy and low back pain. AJNR Am J Neuroradiol. 2008;29(6):1098–103.
Gillan MG, Gilbert FJ, Andrew JE, Grant AM, Wardlaw D, Valentine NW, et al. Influence of imaging on clinical decision making in the treatment of lower back pain. Radiology. 2001;220(2):393–9.
Gilbert FJ, Grant AM, Gillan MG, Vale LD, Campbell MK, Scott NW, et al. Low back pain: influence of early MR imaging or CT on treatment and outcome–multicenter randomized trial. Radiology. 2004;231(2):343–51.
Wilson IB, Dukes K, Greenfield S, Kaplan S, Hillman B. Patients' role in the use of radiology testing for common office practice complaints. Arch Intern Med. 2001;161(2):256–63.
Verbeek J, Sengers MJ, Riemens L, Haafkens J. Patient expectations of treatment for back pain: a systematic review of qualitative and quantitative studies. Spine. 2004;29(20):2309–18.
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Emch, T.M., Modic, M.T. Imaging of lumbar degenerative disk disease: history and current state. Skeletal Radiol 40, 1175–1189 (2011). https://doi.org/10.1007/s00256-011-1163-x
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DOI: https://doi.org/10.1007/s00256-011-1163-x