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Simulation Model Based on Non-Newtonian Fluid Mechanics Applied to the Evaluation of the Embolic Effect of Emulsions of Iodized Oil and Anticancer Drug

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Abstract

Purpose: To verify the difference in embolic effect between oil-in-water (O-W) and water-in-oil (W-O) emulsions composed of iodized oil and an anticancer drug, epirubicin, using a simulation model based on non-Newtonian fluid mechanics.

Methods: Flow curves of pure iodized oil and two types of O-W and W-O emulsions immediately and 1 hr after preparation were examined with a viscometer. Using the yield stress data obtained, we simulated the stagnation of each fluid with steady flow in a rigid tube.

Results: The W-O emulsions were observed to stagnate in the thin tube at a low pressure gradient. However, the embolic effect of the W-O emulsions decreased 1 hr after preparation. The O-W emulsions were stable and did not stagnate under the conditions in which the W-O emulsions stagnated.

Conclusion: The simulation model showed that the embolic effect of the W-O emulsions was superior to that of the O-W emulsions.

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Authors and Affiliations

  1. Department of Radiology, Toyama Prefectural Central Hospital, Nishinagae 2-2-78, Toyama, 930-8550, Japan

    Hiroshi Demachi, Hitoshi Abo & Hiroki Tatsu

  2. Department of Radiology, Kanazawa University, School of Medicine, Takaramachi 13-1, Kanazawa, 920-8641, Japan

    Osamu Matsui

Authors
  1. Hiroshi Demachi
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  2. Osamu Matsui
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  3. Hitoshi Abo
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  4. Hiroki Tatsu
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Demachi, H., Matsui, O., Abo, H. et al. Simulation Model Based on Non-Newtonian Fluid Mechanics Applied to the Evaluation of the Embolic Effect of Emulsions of Iodized Oil and Anticancer Drug. Cardiovasc Intervent Radiol 23, 285–290 (2000). https://doi.org/10.1007/s002700010070

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  • DOI: https://doi.org/10.1007/s002700010070

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