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Classification of three-dimensional thoracic deformities in adolescent idiopathic scoliosis from a multivariate analysis

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Abstract

Purpose

Understanding how to classify and quantify three-dimensional (3D) spinal deformities remains an open question in adolescent idiopathic scoliosis. The objective of this study was to perform a 3D manifold characterization of scoliotic spines demonstrating thoracic deformations using a novel geometric and intuitive statistical tool to determine patterns in pathological cases.

Methods

Personalized 3D reconstructions of thoracic (T)/lumbar (L) spines from a cohort of 170 Lenke Type-1 patients were analyzed with a non-linear manifold embedding algorithm in order to reduce the high-dimensionality of the data, using statistical properties of neighbouring spine models. We extracted sub-groups of the data from the underlying manifold structure using an unsupervised clustering algorithm to understand the inherent distribution and determine classes of pathologies which appear from the low-dimensional space.

Results

For Lenke Type-1 patients, four clusters were detected from the low-dimensional manifold of 3D models: (1) normal kyphosis (T) with hyper-lordosis (L) and high Cobb angles (37 cases), (2) low kyphosis (T) and normal lordosis (L), with high rotation of plane of maximum curvature (55 cases), (3) hypo-kyphotic (T) and hyper-lordosis (L) (21 cases) and (4) hyper-kyphotic (T) with strong vertebral rotation (57 cases). Results show the manifold representation can potentially be useful for classification of 3D spinal pathologies such as idiopathic scoliosis and serve as a tool for understanding the progression of deformities in longitudinal studies.

Conclusions

Quantitative evaluation illustrates that the complex space of spine variability can be modeled by a low-dimensional manifold and shows the existence of an additional hyper-kyphotic subgroup from the cohort of 3D spine reconstructions of Lenke Type-1 patients when compared with previous findings on the 3D classification of spinal deformities.

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Conflict of interest

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Authors and Affiliations

  1. Philips Research North America, 345 Scarborough Rd, Briarcliff Manor, NY, 10510, USA

    Samuel Kadoury

  2. Sainte-Justine Hospital Research Centre, 3175 Cote-Sainte-Catherine, Montreal, QC, H3T 1C5, Canada

    Hubert Labelle

Authors
  1. Samuel Kadoury
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  2. Hubert Labelle
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Corresponding author

Correspondence to Samuel Kadoury.

Additional information

This paper was supported in part by a grant from the Fonds Québecois de la Recherche sur la Nature et les Technologies (FQRNT) and funds from the Scoliosis Research Society.

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Kadoury, S., Labelle, H. Classification of three-dimensional thoracic deformities in adolescent idiopathic scoliosis from a multivariate analysis. Eur Spine J 21, 40–49 (2012). https://doi.org/10.1007/s00586-011-2004-2

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  • DOI: https://doi.org/10.1007/s00586-011-2004-2

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