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MWCNTs and ZnO-based Ce-MOF nanocomposites as enhanced sensing platform for electrochemical detection of carbendazim in Chinese traditional herbs samples

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Abstract

A facile and novel Ce-MOF@MWCNTs@ZnO-modified glassy carbon electrode was prepared through drop coating and used for accurate and sensitive electrochemical detection of carbendazim. The modification of ZnO nanospheres and Ce-based metal-organic frameworks (Ce-MOFs), which possess vast surface/bulk ratio, large surface area, and excellent catalytic ability, provided more active sites for reaction. The combination of multi-walled carbon nanotubes endowed the modified electrode with excellent conductivity and greatly accelerated the electron transfer. The promotion of electrochemical response and the significant improvement of peak current indicated the outstanding electrocatalytic ability of the modified electrode. The oxidation peak current of carbendazim which was measured by DPV in a potential range from 0.5 to 1.0 V produced a good linear relationship in the concentration ranges 0.05–10.0 μM and 10.0–50.0 μM under  optimized experimental conditions. The detection limit was 13.2 nM (S/N = 3). The constructed electrode was successfully applied to the detection of carbendazim in Lithospermum and Glycyrrhiza uralensis real samples and exhibited satisfactory RSD (2.7–3.6% and 1.6–4.8%, respectively) and recovery (102–106% and 97.7–107%, respectively).

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Acknowledgements

The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (NSFC, Grant No. 21005021), Natural Science Foundation of Guangdong Province (No. 2021A1515011410), and Guangdong Provincial Science and Technology Project (No. 2016B030303002).

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Authors and Affiliations

  1. College of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Haohong Lai, Pingtao Ming, Yongxin Liu, Shumei Wang, Qing Zhou & Haiyun Zhai

  2. Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of State Administration of TCM, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Shumei Wang

  3. Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, China

    Haiyun Zhai

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Lai, H., Ming, P., Liu, Y. et al. MWCNTs and ZnO-based Ce-MOF nanocomposites as enhanced sensing platform for electrochemical detection of carbendazim in Chinese traditional herbs samples. Microchim Acta 190, 281 (2023). https://doi.org/10.1007/s00604-023-05869-x

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