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A nickel nanoparticle/carbon nanotube-modified carbon fiber microelectrode for sensitive insulin detection

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Abstract

A nickel nanoparticle (NiNP)/carbon nanotube (CNT)-modified carbon fiber microelectrode (NiNPs/CNTs/CFME) was fabricated using a two-step electroless plating/chemical vapor deposition method. The morphology of the NiNPs/CNTs composite structure was characterized by scanning electron microscopy, and its elemental composition was characterized by an energy dispersive spectrometer. The electrochemical behavior of the NiNPs/CNTs/CFME in aqueous alkaline solutions of insulin was investigated by cyclic voltammetry (CV), chronoamperometry, and electrochemical impedance spectroscopy in sequence. CV curves show that the NiNPs/CNTs/CFME displays a high oxidation peak current, a fast electron transfer rate, and good electrocatalytic activity towards insulin, compared to a bare CFME and a pure NiNP-modified CFME. In the chronoamperometry tests, the NiNPs/CNTs/CFME demonstrates an excellent analytical performance in detecting low concentrations of insulin, including good sensitivity (1.11 nA μM−1) and a low detection limit (270 nM). Moreover, this microelectrode exhibits great reproducibility in successive potential cycling and satisfactory long-term stability after storage at room temperature for approximately 8 weeks.

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Acknowledgments

The present research was supported by the National Natural Science Foundation of China (Nos. 51375175), the Natural Science Foundation of Guangdong Province, China (Nos. 2015A030313201 and 2014A030312017), and the Science and Technology Planning Project of Guangdong Province, China (No. 2015A010105007). The authors also thank to the Pearl River S&T Nova Program of Guangzhou.

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Authors and Affiliations

  1. School of Mechanical and Automotive Engineering, South China University of Technology, 381# Wushan Road, Guangzhou, 510641, China

    Longsheng Lu, Linsheng Liang, Yingxi Xie, Zhenping Wan & Songmao Chen

  2. Department of Mechanical Engineering, Penn State Harrisburg, 777 West Harrisburg Pike, Middletown, PA, 17057, USA

    Kairui Tang

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  1. Longsheng Lu
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  2. Linsheng Liang
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  3. Yingxi Xie
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  4. Kairui Tang
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  5. Zhenping Wan
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  6. Songmao Chen
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Correspondence to Longsheng Lu.

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Lu, L., Liang, L., Xie, Y. et al. A nickel nanoparticle/carbon nanotube-modified carbon fiber microelectrode for sensitive insulin detection. J Solid State Electrochem 22, 825–833 (2018). https://doi.org/10.1007/s10008-017-3816-8

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  • DOI: https://doi.org/10.1007/s10008-017-3816-8

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