Abstract
In this paper we compare several approaches to identifying certain key respiratory control parameters relying on data normally available from non-invasive measurements. We consider a simple model of the respiratory control system and describe issues related to numerical estimates of key parameters involved in respiratory function such as central and peripheral control gains, transport delay, and lung compartment volumes. The combination of model-specific structure and limited data availability influences the parameter estimation process. Methods for studying how to improve the parameter estimation process are examined including classical and generalized sensitivity analysis, and eigenvalue grouping. These methods are applied and compared in the context of clinically available data. These methods are also compared in conjunction with specialized tests such as the minimally invasive single-breath CO2 test that can improve the estimation, and the enforced fixed breathing test, which opens the control loop in the system. The analysis shows that it is impossible to estimate central and peripheral gain simultaneously without usage of ventilation measurement and a controlled perturbation of the respiratory system, such as the CO2 test. The numerical results are certainly model dependent, but the illustrated methods, the nature of the comparisons, and protocols will carry over to other models and data configurations.
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References
Aittokallio T, Gyllenberg M, Polo O, Virkki A. Parameter estimation of a respiratory control model from noninvasive carbon dioxide measurements during sleep. Math Med Biol 2007;24:225–49.
Batzel JJ, Tran HT. Modeling instability in the control system for human respiration: applications to infant non-rem sleep. Appl Math Comput 2000;110:1–51.
Cobelli C, DiStefano JJ. Parameter and structural identifiability concepts and ambiguities: a critical review and analysis. Am J Physiol 1980;27:R7–24.
Fink M. myAD: fast automatic differentiation code in Matlab. 2006 http://www.mathworks.com/matlabcentral/fileexchange/loadFile.do?objectId=15235
Khoo MC. A model-based evaluation of the single-breath CO2 ventilatory response test. J Appl Physiol 1990;68:393–9.
Khoo MC, Kronauer R, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol 1982;53:644–59.
McClean PA, Phillipson EA, Martinez D, Zamel N. Single breath of CO2 as a clinical test of the peripheral chemoreflex. J Appl Physiol 1988;64:84–9.
Nattie E. Why do we have both peripheral and central chemoreceptors?. J Appl Physiol 2006;100:9–10.
Pedersen ME, Fatemian M, Robbins PA. Identification of fast and slow ventilatory responses to carbon dioxide under hypoxic and hyperoxic conditions in humans. J Physiol 1999;521 (Pt 1):273–87.
Reid JG. Structural identifiability in linear time-invariant systems. IEEE Trans Automat Control 1977;22:242–46.
Thomaseth K, Cobelli C. Generalized sensitivity functions in physiological system identification. Ann Biomedical Eng 1999;27:607–16.
Acknowledgements
This research was partially funded by FWF (Austria) project P18778-N13. The work by Hien Tran was partially supported by NIH/NIAID 9 R01 AI071915-05, NSF OISE-0437037, and NSF DMS-0616597.
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Fink, M., Batzel, J.J. & Tran, H. A Respiratory System Model: Parameter Estimation and Sensitivity Analysis. Cardiovasc Eng 8, 120–134 (2008). https://doi.org/10.1007/s10558-007-9051-7
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DOI: https://doi.org/10.1007/s10558-007-9051-7