Abstract
The topical administration of trans-resveratrol is limited because of its fast degradation upon UV irradiation. As assessed in the literature, cyclodextrins are able to protect the guest molecule against photodegradation. Accordingly, in this report the possibility of forming a stable complex between resveratrol and hydroxypropyl-β-cyclodextrin was firstly checked by docking strategies and then confirmed by solubility diagrams and differential scanning calorimetric measurements. The rate of degradation of resveratrol was then followed in different systems under UVA irradiation: the results showed the photoprotective effect of the complex. Moreover, the radical scavenging activity, the metal-chelating efficiency and the anti-lipoperoxidative potential of resveratrol were assessed: data showed that the inclusion phenomenon did not significatively interfere with these biological properties. Finally, in vitro experiments revealed that the skin accumulation of resveratrol was higher when released from the complex then when deposited alone.
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Soleas, G.J., Diamandis, E.P., Goldberg, D.M.: Wine as a biological fluid: history, production, and role in disease prevention. J. Clin. Lab. Anal. 11, 287–313 (1997). doi:10.1002/(SICI)1098-2825(1997)11:5<287::AID-JCLA6>3.0.CO;2-4
Faustino, R.S., Clark, T.A., Sobrattee, S., Czubryl, M.P., Pierce, G.N.: Differential antioxidant properties of red wine in water soluble and lipid soluble peroxyl radical generating systems. Mol. Cell. Biochem. 263, 211–215 (2004). doi:10.1023/B:MCBI.0000041862.89750.93
Filip, V., Plocková, M., Šmidrkal, J., Špičková, Z., Melzoch, K., Schmidt, Š.: Resveratrol and its antioxidant and antimicrobial effectiveness. Food Chem. 83, 585–593 (2003). doi:10.1016/S0308-8146(03)00157-2
Marinova, E.M., Yanishlieva, N.V., Totseva, I.R.: Anti-oxidant activity and mechanism of action of trans-resveratrol in different lipid systems. Int. J. Food Sci. Technol. 37, 145–152 (2002). doi:10.1046/j.1365-2621.2002.00551.x
Jang, M., Pezzuto, J.M.: Cancer chemopreventive activity of resveratrol. Drugs Exp. Clin. Res. 25, 65–77 (1999)
Fontecave, M., Lepoivre, M., Elleingand, E., Gerez, C., Guittet, O.: Resveratrol, a remarkable inhibitor of ribonucleotide reductase. FEBS Lett. 421, 277–279 (1998). doi:10.1016/S0014-5793(97)01572-X
Stojanović, S., Sprinz, H., Brede, O.: Efficiency and mechanism of the antioxidant action of trans- resveratrol and its analogues in the radical liposome oxidation. Arch. Biochem. Biophys. 391, 79–89 (2001). doi:10.1006/abbi.2001.2388
Afaq, F., Adhami, V.M., Ahmad, N.: Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol. Appl. Pharmacol. 186, 28–37 (2003). doi:10.1016/S0041-008X(02)00014-5
Hsieh, T., Wang, Z., Hamby, C.V., Wu, J.M.: Inhibition of melanoma cell proliferation by resveratrol is correlated with up regulation of quinone reductase 2 and p53. Biochem. Biophys. Res. Commun. 334, 223–230 (2005). doi:10.1016/j.bbrc.2005.06.073
Soleas, G.J., Grass, L., Josephy, P.D., Goldberg, D.M., Diamandis, E.P.: A comparison of the anticarcinogenic properties of four red wine polyphenols. Clin. Biochem. 39, 492–497 (2006). doi:10.1016/j.clinbiochem.2006.04.014
Wang, Y., Catana, F., Yang, Y., Roderick, R., van Breemen, R.B.: An LC-MS method for analyzing total resveratrol in grape juice, cranberry juice and in wine. J. Agric. Food Chem. 50, 431–435 (2002). doi:10.1021/jf010812u
Roggero, J.P.: Study of the ultraviolet irradiation of resveratrol and wine. J. Food Compost. Anal. 13, 93–97 (2000). doi:10.1006/jfca.1999.0846
Bertacche, V., Lorenzi, N., Nava, D., Pini, E., Sinico, C.: Host-guest interaction study of resveratrol with natural and modified cyclodextrins. J. Incl. Phenom. Macrocycl. Chem. 55, 279–287 (2006). doi:10.1007/s10847-006-9047-8
Marier, J.-F., Vachon, P., Gritsas, A., Zhang, J., Moreau, J.-P., Ducharme, M.P.: Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J. Pharmacol. Exp. Ther. 302, 369–373 (2002). doi:10.1124/jpet.102.033340
Gao, D., Zhang, X., Jiang, X., Zhang, W., Peng, Y., Wang, X., Wang, X., Song, L.: Effect of resveratrol on matrix metalloproteinase 9 induced by injury of cerebral ischemia-reperfusion in mice. Zhonghua Shenjing Waike jibing Yanjiu Zazhi 6(2), 100–103 (Chinese). Chem. Abstr. 147, 134116 (2007)
MOE: version 2007.09.02, 2007, Chemical Computing Group. Montreal, Quebec, Canada, http://www.chemcomp.com/
Sapino, S., Trotta, M., Ermondi, G., Caron, G., Cavalli, R., Carlotti, M.E.: On the complexation of Trolox with methyl-β-cyclodextrin: characterization, molecular modelling and photostabilizing properties. J. Incl. Phenom. Macrocycl. Chem. (2008). doi:10.1007/s10847-008-9454-0
Higuchi, T., Connors, K.A.: Phase solubility techniques. Adv. Anal. Chem. Instrum. 4, 117–212 (1965)
Brand-Williams, W., Cuvelier, M.E., Berset, C.: Use of a free radical method to evaluate antioxidant activity. Lebenson. Wiss. Technol. 28, 25–30 (1995). doi:10.1016/S0023-6438(95)80008-5
Gutteridge, J.M., Halliwell, B.: The measurement and mechanism of lipid peroxidation in biological system. Trends Biochem. Sci. 15, 129–134 (1990). doi:10.1016/0968-0004(90)90206-Q
Kovachich, G.B., Mishra, O.P.: Lipid peroxidation in rat brain cortical slices as measured by the thiobarbituric acid test. J. Neurochem. 35, 1449–1452 (1980). doi:10.1111/j.1471-4159.1980.tb09022.x
Halperin, I., Ma, B., Wolfson, H., Nussinov, R.: Principles of docking: an overview of search algorithms and a guide to scoring functions. Proteins 47, 409–443 (2002). doi:10.1002/prot.10115
López-Nicolás, J.M., Núñez-Delicado, E., Pérez-López, A.J., Barrachina, Á.C., Cuadra-Crespo, P.: Determination of stoichiometric coefficients and apparent formation constants for beta-cyclodextrin complexes of trans-resveratrol using reversed-phase liquid chromatography. J. Chromatogr. A 1135, 158–165 (2006). doi:10.1016/j.chroma.2006.09.013
Lucas-Abellán, C., Fortea, I., López-Nicolás, J.M., Núñez-Delicado, E.: Cyclodextrins as resveratrol carrier system. Food Chem. 104, 39–44 (2007). doi:10.1016/j.foodchem.2006.10.068
Bayomi, M.A., Abanumay, K.A., Al-Angary, A.A.: Effect of inclusion complexation with cyclodextrins on photostability of nifedipine in solid state. Int. J. Pharm. 243, 107–117 (2002). doi:10.1016/S0378-5173(02)00263-6
Carlotti, M.E., Sapino, S., Vione, D., Pelizzetti, E., Trotta, M.: Photostability of Trolox in water/ethanol, water and Oramix CG 110 in the absence and in the presence of TiO2. J. Disp. Sci. Technol. 25, 193–207 (2004). doi:10.1081/DIS-120030666
Gallarate, M., Chirio, D., Trotta, M., Carlotti, M.E.: Deformable liposomes as topical formulations containing α-tocopherol. J. Disp. Sci. Technol. 27, 703–713 (2006). doi:10.1080/01932690600662588
Murias, M., Jäger, W., Handler, N., Erker, T., Horvath, Z., Szekeres, T., Nohl, H., Gille, L.: Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship. Biochem. Pharmacol. 69, 903–912 (2005). doi:10.1016/j.bcp.2004.12.001
Belguendouz, L., Fremont, L., Linard, A.: Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem. Pharmacol. 53, 1347–1355 (1997). doi:10.1016/S0006-2952(96)00820-9
Diembeck, W., Bekc, H., Benech-Kieffer, F., Courtellemonth, P., Dupuis, J., Lovell, W., Paye, M., Spengler, M., Steiling, W.: Test guidelines for in vitro assessment of dermal absorption and percutaneous penetration of cosmetic ingredients. Food Chem. Toxicol. 37, 191–205 (1999). doi:10.1016/S0278-6915(98)00114-8
Godwin, D.A., Wiley, C.J., Felton, L.A.: Using cyclodextrin complexation to enhance secondary photoprotection of topically applied ibuprofen. Eur. J. Pharm. Biopharm. 62, 85–93 (2006). doi:10.1016/j.ejpb.2005.06.002
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The authors are grateful to Roquette (Lestreme, France) for providing the HP-β-CD.
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Sapino, S., Carlotti, M.E., Caron, G. et al. In silico design, photostability and biological properties of the complex resveratrol/hydroxypropyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem 63, 171–180 (2009). https://doi.org/10.1007/s10847-008-9504-7
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DOI: https://doi.org/10.1007/s10847-008-9504-7