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Polymeric Prodrugs Containing Metal-Based Anticancer Drugs

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Journal of Inorganic and Organometallic Polymers and Materials Aims and scope Submit manuscript

Abstract

Prodrugs optimize the absorption, distribution, metabolism, excretion and reduce unwanted toxicity of the parent drugs. The medicinal application of polymeric prodrugs for delivery of metal-based anticancer drugs is a field of increasing prominence because metal-based drugs offer possibilities for the design of therapeutic agents that are not readily available to organic compounds. This review is focused on the progress of polymeric prodrugs of metal based anticancer agents. A better understanding of the pharmacokinetics of these prodrugs will provide a rational for their further development into anticancer drugs for overcoming multidrug resistance.

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Correspondence to B. A. Aderibigbe.

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This article is written in memory of late Prof. E.W. Neuse (em) who dedicated his research towards the design and characterization of polymer-drug conjugates containing metal based anticancer drugs.

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Aderibigbe, B.A. Polymeric Prodrugs Containing Metal-Based Anticancer Drugs. J Inorg Organomet Polym 25, 339–353 (2015). https://doi.org/10.1007/s10904-015-0220-7

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  • DOI: https://doi.org/10.1007/s10904-015-0220-7

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