Abstract
A new functional monomer based on vanillin was synthetized and used in the preparation of three different molar concentrations of temperature and pH responsive photo-cross-linker polymers via free radical polymerization with N-isopropylacryamide and malimide photo-cross-linker. Polymers were investigated by 1HNMR, FTIR, UV, gel permeation chromatography (GPC) and differential scanning calorimetery (DSC). The non-responsive copolymers have been synthetized from N,N-dimemthylacrylamide with malimide. Lower critical solution temperatures (T c ) were determined by UV–Vis spectroscopy. Hydrogel bilayer was formed by spin coating of polymer solution of poly(N-isopropylacryamide-Co-malimide-Co-DEAMVA) layer A over gold with adhesion promoter, then cross-linked by UV-irradiation. The swelling properties were determined by surface plasmon resonance with optical waveguides (SPR/OW). The T c of hydrogel was also determined as function of volume degree of swelling or refractive index with temperature at different pH. The next layer was formed by spin coating of polymer solution poly(N,N-dimemthylacrylamid-Co-malimide) layer B over layer A, then cross-linked by UV-irradiation. The swelling properties and T c were determined by SPR/OW in different media. Our target is the formation of biosensor functional gel vessel for biological molecules using aldehyde group. The bilayer functional hydrogels will have an additional feature, in which the target molecule stays safely inside this gel vessel responsively temperature and pH.
Graphical Abstract
New acrylate monomer from vanillin has been synthetized with aldehyde and tertiary amine group to achieve both functionality and pH responsive. The copolymerization with NIPAAm and DMIAAm has done forming pH and temperature photo-cross-linked polymers. Hydrogel layer was built first with mono then bilayer and both has characterized by SPR/OW. The effect of non-responsive layer on the responsive one was demonstrated. In future we will use this technique as biosensor hydrogel for vessel to attach and detach biomolecules, further drug-delivery.
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References
Abdelaty MSA (2017) J Polym Environ 3:1
Abdelaty MSA, Kuckling D (2016) Gels 2:1
Deshmukh PK, Ramani KP, Singh SS, Tekade AR, Chatap VK, Patil GB, Bari SB (2013) J Control Release 166:294
Kikuchi A, Okano T (2002) Prog Polym Sci 27:1165
Ware T, Simon D, Rennaker RL, Voit W (2013) Smart polymers for neural interfaces. Polym Rev 53:108
Hamner KL, Alexander CM, Coopersmith K, Reishofer D, Provenza C, Maye MM (2013) ACS Nano 7:7010
Qiu Y, Park K (2001) Adv Drug Deliv Rev 53:321
Sato E, Masuda Y, Kadota J, Nishiyama T, Horibe H (2015) Eur Polym J 69:607–615
Chen J-K, Chang C-J (2014) Materials 7:805
Meng H, Mohamadian H, Stubblefield M, Jerro D, Ibekwe S, Pang SS, Li GQ (2013) Smart Mater Struct 22(9):093001
Zhang M, Estournes C, Bietsch W, Mueller AHE (2004) Adv Funct Mater 14:871
Matsukuma D, Yamamoto K, Aoyagi T (2006) Langmuir 22:5911
Chen Y, Pang X-H, Dong C-M (2010) Adv Funct Mater 20:579
Schattling P, Jochum F-D, Theato P (2014) Poly Chem 5:25
Li Y, Zhang C, Zhou Y, Dong Y, Chen W (2015) Eur Polym J 69:441
Fujiwara N, Asaka K, Nishimura Y, Oguro K, Torikai E (2000) Chem Mater 12:1750
Roy D, Cambre JN (2011) In: Urban MW (ed) B. S. Sumerlin in handbook of stimuli-responsive materials. Wiley-VCH, Weinheim
Xia Y, Yin X, Burke NAD, Stoever HDH (2005) Macromolecules 38:5937
Cheng G, Boeker A, Zhang M, Krausch G, Mueller AHE (2001) Macromolecules 34:6883
Chen JK, Wang JH, Fan SK, Chang JY (2012) J Phys Chem C 116:6992
Seuring J, Agarwal S (2012) Macromol Rapid Commun 33:1898
Chang K, Rubright NC, Lowery PD, Taite LJ (2013) J Polym Sci APolym Chem 51:2068
Heskins M, Guillet JE (1968) J Macromol Sci Chem A 2:1441
Okubo M, Ahmad H, Suzuki T (1998) Colloid Polym Sci 276:470
Iatridi Z, Mattheolabakis G, Avgoustakis K, Tsitsilianis C (2011) Soft Matter 7:11160
Liu X, Yu D, Jin C, Song X, Cheng J, Zhao X, Qi X, Zhang G (2014) New J Chem 38:4821
Soppimath KS, Tan D. C.-W., Yang Y-Y (2005) Adv Mater 17:318
Delcea M, Möhwald H, Skirtach AG (2011) Adv Drug Deliv Rev 63:730
Uhlig K, Boysen B, Lankenau A, Jaeger M, Wischerhoff E, Lutz J-F, Laschewsky A, Duschl C (2012) Biomicrofluidics 6:11
Skirtach AG, Yashchenok AM, Möhwalda H (2011) Chem Commun 47:12736
Bedard M, Skirtach AG, Sukhorukov GB (2007) Macromol Rapid Commun 28:1517
Honda M, Kataoka K, Seki T, Takeoka Y (2009) Langmuir 25:8349
Fleischmann EK, Zentel R (2013) Angew Chem Int Ed 52:8810
Zhang C, Madbouly SA, Kessler MR (2015) Macromol Chem Phys 216:1816
Stanzione JF, Sadler JM, La Scala JJ, Wool RP (2012) Chem Sus Chem 5:1291
Fache M, Darroman E, Besse V, Auvergne R, Sylvain Caillol S, Boutevina B (2014) Green Chem16:1987
Mateescu A, Wang Y, Dostalek J, Jonas U (2012) Membranes 2:40
Feng X, Wu H, Sui X, Hempenius MA, JuliusVancso G (2015) Eur Polym J 72:535
Tokarev I, Minko S (2009) Soft Matter 5:511
Harmon ME, Kuckling D, Pareek P, Frank CW (2003) Langmuir 19:10947
Kuckling D, Harmon ME, Frank CW (2002) Macromolecules 35:6377
Harmon ME, Kuckling D, Frank CW (2003) Macromolecules 36:162
Nan Zhang N, Knoll W (2009) Anal Chem 81:2611
Anac I, Aulasevich A, Junk MJN, Jakubowicz P, Roskamp RF, Menges B, Jonas U, Knoll W (2010) Macrmol Chem Phys 211:1018
Chen JK, Chan CH, Chang FC (2008) Appl Phys Lett 92(1):053108
Chan CH, Chen JK, Chang FC (2008) Sens Actuat B 133:327
Chen JK, Li JY (2010) Sens Actuat B 150:314
Hosoya K, Kubo T, Tanaka N, Haginaka JA (2003) J Pharm Biomed Anal 30:1919
Lu Y, Mei Y, Drechsler M, Ballauff M (2006) Angew Chem Int Ed 45:813
Li X, Yu XH, Han YC (2012) Langmuir 28:10584
Wan PB, Eric HH, Zhang X (2012) Prog Chem 24:1
Ebara M, Yamato M, Hirose M, Aoyagi T, Kikuchi A, Sakai K, Okano T (2003) Biomacromolecules 4:344
Uakushiji T, Sakai K, Kikuchi A, Aoyagi T, Sakurai Y, Okano T (1998) Langmuir 14:4657–4662
Chen JK, Wang JH, Chang JY, Fan SK (2012) Appl Phys Lett 101(1):123701
Costa E, Coelho M, Ilharco LM, Aguiar-Ricardo A, Hammond PT (2011) Macromolecules 44:612
Yang HW, Chena JK, Cheng CC, Kuo SW (2013) Appl Surf Sci 271:60
Gauthier MA, Gibson MI, Klok HA (2009) Angew Chem Int Ed 48:48
Fuchs AD, Tiller JC (2006) Angew Chem Int Ed 45:6759
Zolotukhin MG, Colquhoun HM, Sestiaa LG, Rueda DR, Flot D (2003) Macromolecule 36:4766
Brooks Y-E, Kizhakkedathu JN (2008) Macromolecules 41:5393
Schneider BH, Dickinson EL, Vach MD, Hoijer JV, Howard LV (2000) Biosens Bioelectron 15:13
Vaisocherova H, Yang W, Zhang Z, Cao ZQ, Cheng G, Piliarik M, Homola J, Jiang SY (2008) Anal Chem 80:7894
Wark AW, Lee HJ, Corn RM (2005) Anal Chem 77:3904
Lakhiari H, Okano T, Nurdin N, Luthi C, Descouts P, Muller D, Jozefonvicz J (1998) Biochim Biophys Acta 1379:303
Kanazawa H, Yamamoto K, Matsushima Y, Takai N, Kikuchi A, Sakurai Y, Okano T (1996) Anal Chem 68:100
Bhattacharya S, Eckert F, Boyko V, Pich A (2007) Small 3:650–657
Xulu PM, Filipcsei G, Zrinyi M (2000) Macromolecules 33:1716
Acknowledgements
The authors are grateful acknowledge to Egyptian culture and missions, and The Deutscher Akademischer Austauch (DAAD) for financial assistance during the post doctor work in Germany of Momen S.A. Abdelaty.
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Abdelaty, M.S.A. Environmental Functional Photo-Cross-Linked Hydrogel Bilayer Thin Films from Vanillin. J Polym Environ 26, 2243–2256 (2018). https://doi.org/10.1007/s10924-017-1126-y
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DOI: https://doi.org/10.1007/s10924-017-1126-y