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Synthesis of novel coumarin substituted amide derivatives and their antibacterial activities

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Abstract

A series of novel coumarin substituted amide derivatives were synthesized and evaluated for their antibacterial activities. Result indicated that compounds 3f, 3g, 3h, 3i, 3j, 3k, 3l, 3m, 3n, 3o and 3q exhibited excellent antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas citri subsp. Citri (Xcc) in vitro, which were better than those of commercial agricultural antibacterial thiodiazole-copper. The title compounds with electron-withdrawing group showed better antibacterial activities than those of compounds with electron-donating group, and the title compounds bearing the same substituent group exhibited better antibacterial activities against Xcc than antibacterial activities against Xoo.

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Notes

  1. All of new compounds were named with IUPAC name

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Acknowledgements

This work was financially supported by the Science and Technology Fund of Guizhou Province (No. [2011]2080), Natural Science Fund of Guizhou Province Education (No. 2010079) and Dr. Fund of Tongren University (No. trxyDH1618).

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    Authors and Affiliations

    1. School of Material and Chemistry Engineering, Tongren University, Bijiang District, Tongren, 554300, China

      Mei-Hang Chen, Dao-Wang Lu, Xun Zhang, Zeng-Yan Zhou & Hua Shu

    2. State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang, 550025, China

      Xiao-Bin Wang

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    Correspondence to Mei-Hang Chen.

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    Mei-Hang Chen and Dao-Wang Lu have contributed equally to this work.

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    Chen, MH., Lu, DW., Zhang, X. et al. Synthesis of novel coumarin substituted amide derivatives and their antibacterial activities. Chem. Pap. 71, 1579–1586 (2017). https://doi.org/10.1007/s11696-017-0149-0

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