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Three-dimensional chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering

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Abstract

We describe the structure of biodegradable chitosan-nanohydroxyapatite (nHA) composites scaffolds and their interaction with pre-osteoblasts for bone tissue engineering. The scaffolds were fabricated via freezing and lyophilization. The nanocomposite scaffolds were characterized by a highly porous structure and pore size of ∼50–125 μm, irrespective of nHA content. The observed significant enhancement in the biological response of pre-osteoblast on nanocomposite scaffolds expressed in terms of cell attachment, proliferation, and widespread morphology in relation to pure chitosan points toward their potential use as scaffold material for bone regeneration.

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References

  1. A.D. Marino et al., Biomaterials, 26 (2005), pp. 5983–5990.

    Article  Google Scholar 

  2. E. Khor et al., Biomaterials, 24 (2003), pp. 2339–2349.

    Article  PubMed  CAS  Google Scholar 

  3. W.W. Thein-Han et al., Materials Science and Technology, 24(9) (2008), pp. 1062–1075.

    Article  CAS  Google Scholar 

  4. R. Langer and J.P. Vacanti, Science, 260 (1993), pp. 920–926.

    Article  PubMed  ADS  CAS  Google Scholar 

  5. J.P. Vacanti and R. Langer, Lancet, 354(354:suppli 1) (1999), pp. SI32–SI34.

    PubMed  Google Scholar 

  6. B-S. Kim and D.J. Mooney, Trends Biotechnol., 16 (1998), pp. 224–230.

    Article  PubMed  CAS  Google Scholar 

  7. S.V. Madihally and H.W.T. Matthew, Biomaterials, 20 (1999), pp. 1133–1142.

    Article  PubMed  CAS  Google Scholar 

  8. J.K.F. Suh and H.W.T. Matthew, Biomaterials, 21 (2000), pp. 2589–2598.

    Article  PubMed  CAS  Google Scholar 

  9. R.A.A. Muzzarelli, Chitin (Oxford, U.K.: Pergamon Press, 1977).

    Google Scholar 

  10. S. Hirano, Biotechnology Annual Review, vol. 2 (Amsterdam: Elsevier Science, 1996), pp. 237–258.

    Google Scholar 

  11. R.A.A. Muzzarelli et al., EXS, 87 (1999), pp. 251–264.

    PubMed  CAS  Google Scholar 

  12. R.A.A. Muzzarelli et al., Biomaterials, 9 (1988), pp. 247–252.

    Article  PubMed  CAS  Google Scholar 

  13. W.W. Thein-Han and W.F. Stevens, Drug. Dev. Ind. Pharm., 30 (2004), pp. 397–404.

    Article  PubMed  CAS  Google Scholar 

  14. W.W. Thein-Han and R.D.K. Misra, Acta Biomaterialia, 5(4) (2008), pp. 1182–1197.

    Article  PubMed  Google Scholar 

  15. K.T. Bowers et al., Int. J. Oral. Maxillofac. Implants, 7(3) (1992), pp. 302–310.

    PubMed  CAS  MathSciNet  Google Scholar 

  16. D.J. Trylovich et al., J. of Periodontology, 63 (1992), pp. 63:626–632.

    Google Scholar 

  17. M.A. Aronow et al., J. Cell. Physiol., 143(2) (1990), pp. 213–221.

    Article  PubMed  CAS  Google Scholar 

  18. G. Akay et al., Biomaterials, 25(18) (2004), pp. 3991–4000.

    Article  PubMed  CAS  Google Scholar 

  19. A. Sendemir-Urkmez et al., J. Biomed. Mater. Res., 81A(3) (2007), pp. 624–633.

    Article  CAS  Google Scholar 

  20. K. L. Kilpadi et al., J. Biomed. Mater. Res., 57(2) (2001), pp. 258–267.

    Article  PubMed  CAS  Google Scholar 

  21. K. Anselme, Biomaterials, 21 (2000), pp. 667–681.

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, University of Louisiana at Lafayette, P.O. Box 44130, Lafayette, LA, 70504-4130, USA

    W. W. Thein-Han & R. D. K. Misra

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  1. W. W. Thein-Han
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  2. R. D. K. Misra
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Correspondence to R. D. K. Misra.

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Thein-Han, W.W., Misra, R.D.K. Three-dimensional chitosan-nanohydroxyapatite composite scaffolds for bone tissue engineering. JOM 61, 41–44 (2009). https://doi.org/10.1007/s11837-009-0131-6

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  • DOI: https://doi.org/10.1007/s11837-009-0131-6

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