Abstract
Honey is a natural medicine; incorporating it, a PVA/honey hybrid nanofibrous Band-Aid was fabricated by electrospinning technique, and the prepared electrospun scaffolds were characterized by UV–visible spectroscopy, FTIR spectroscopy and XRD techniques. The honey-adsorbed scaffolds showed UV–visible absorption at 306 nm wavelength expressing the presence of honey in polymer scaffold. In addition, it indicated that the honey was not degenerated even at the highest applied voltage of 16 kV given during electrospinning. Conductivity study of the scaffold revealed linear increase of conductivity as 0.74, 0.80, 0.82 and 0.83 mho with increase of honey concentration, which revealed the high honey releasing profile of the scaffolds at higher concentration. Efficiency of fabricated Band-Aids was analyzed by swelling character and in vitro releasing kinetics. The higher level of honey osmolality increased the fluid uptake into scaffolds and showed highest degree of swelling indicating an efficient release of honey by diffusion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
AbdElaziz AM, ElMaghraby A, Taha NA (2017) Comparison between polyvinyl alcohol (PVA) nanofiber and polyvinyl alcohol (PVA) nanofiber/hydroxyapatite (HA) for removal of Zn2+ ions from wastewater. Arab J Chem 10:1052–1060. https://doi.org/10.1016/j.arabjc.2016.09.025
Albaridi NA (2019) Antibacterial potency of honey. Int J Microbiol 2019:10. https://doi.org/10.1155/2019/2464507
Anand S, Deighton M, Livanos G, Morrison PD, Pang ECK, Mantri N (2019) Antimicrobial activity of Agastache honey and characterization of its bioactive compounds in comparison with important commercial honeys. Front Microbiol. https://doi.org/10.3389/fmicb.2019.00263
Anderson DEJ, Truong KP, Hagen MW, Yim EKF, Hinds MT (2019) Biomimetic modification of poly(vinyl alcohol): encouraging endothelialization and preventing thrombosis with antiplatelet monotherapy. Acta Biomater 86:291–299. https://doi.org/10.1016/j.actbio.2019.01.008
Awada H, Daneault C (2015) Chemical modification of poly(vinyl alcohol) in water applied. Sciences 5:840–850
Biswas A, Amarajeewa M, Senapati S, Sahu M, Maiti P (2018) Sustained release of herbal drugs using biodegradable scaffold for faster wound healing and better patient compliance. Nanomedicine 14:2131–2141. https://doi.org/10.1016/j.nano.2018.07.003
Chao CY, Mani MP, Jaganathan SK (2018) Engineering electrospun multicomponent polyurethane scaffolding platform comprising grape seed oil and honey/propolis for bone tissue regeneration. PLoS ONE ONE 13:e0205699. https://doi.org/10.1371/journal.pone.0205699
Costa MF, Durco AO, Rabelo TK, Barreto RSS, Guimaraes AG (2019) Effects of carvacrol, thymol and essential oils containing such monoterpenes on wound healing: a systematic review. J Pharm Pharmacol 71:141–155. https://doi.org/10.1111/jphp.13054
Elkomy GM, Mousa SM, Mostafa HA (2016) Structural and optical properties of pure PVA/PPY and cobalt chloride doped PVA/PPY films. Arab J Chem 9:S1786–S1792. https://doi.org/10.1016/j.arabjc.2012.04.037
ElZaher NA, Osiris WG (2005) Thermal and structural properties of poly(vinyl alcohol) doped with hydroxypropyl cellulose. J Appl Polym Sci 96:1914–1923. https://doi.org/10.1002/app.21628
Gupta D, Jassal M, Agrawal AK (2016) The electrospinning behavior of poly(vinyl alcohol) in DMSO–water binary solvent mixtures. RSC Adv 6:102947–102955. https://doi.org/10.1039/C6RA15017A
Hassiba AJ et al (2017) Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications. Int J Nanomed 12:2205–2213. https://doi.org/10.2147/ijn.S123417
Kwakman PHS, Velde AAT, Boer LD, Speijer D, Vandenbroucke-Grauls CMJE, Zaat SAJ (2010) How honey kills bacteria. FASEB J 24:2576–2582. https://doi.org/10.1096/fj.09-150789
Li N, Qin X-H, Lin L, Wang S-Y (2008) The effects of spinning conditions on the morphology of electrospun jet and nonwoven membrane. Polym Eng Sci 48:2362–2366. https://doi.org/10.1002/pen.21188
Li J et al (2017) Polymer materials for prevention of postoperative adhesion. Acta Biomater 61:21–40. https://doi.org/10.1016/j.actbio.2017.08.002
Lin SY, Chen KS, Run-Chu L (2001) Design and evaluation of drug-loaded wound dressing having thermoresponsive, adhesive, absorptive and easy peeling properties. Biomaterials 22:2999–3004. https://doi.org/10.1016/S0142-9612(01)00046-1
Long Y, Wei H, Li J, Yao G, Yu B, Ni D, Gibson AL, Lan X, Jiang Y, Cai W, Wang X (2018) Effective wound healing enabled by discrete alternative electric fields from wearable nanogenerators. ACS NanoNano 12(12):12533–12540
Maleki H, Gharehaghaji AA, Dijkstra PJ (2013) A novel honey-based nanofibrous scaffold for wound dressing application. J Appl Polym Sci 127:4086–4092. https://doi.org/10.1002/app.37601
Mama M, Teshome T, Detamo J (2019) Antibacterial activity of honey against methicillin-resistant staphylococcus aureus: a laboratory-based experimental study. Int J Microbiol 2019:9. https://doi.org/10.1155/2019/7686130
Meo SA, AlAsiri SA, Mahesar AL, Ansari MJ (2017) Role of honey in modern medicine. Saudi J Biol Sci 24:975–978. https://doi.org/10.1016/j.sjbs.2016.12.010
MindenBirkenmaier BA, Bowlin GL (2018) Honey-based templates in wound healing and tissue engineering. Bioengineering 5:46
Moore OA, Smith LA, Campbell F, Seers K, McQuay HJ, Moore RA (2001) Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med 1:2. https://doi.org/10.1186/1472-6882-1-2
Moura LIF, Dias AMA, Carvalho E, de Sousa HC (2013) Recent advances on the development of wound dressings for diabetic foot ulcer treatment a review. Acta Biomater 9:7093–7114. https://doi.org/10.1016/j.actbio.2013.03.033
Movassaghi S, Sharifi ZN, Koosha M, Abdollahifar MA, Fathollahipour S, Tavakoli J, Abdi S (2019) Effect of Honey/PVA Hydrogel Loaded by Erythromycin on Full-Thickness. Galen Med J 2019:8. https://doi.org/10.31661/gmj.v8i0.1362
NeresSantos AM et al (2019) Physically cross-linked gels of PVA with natural polymers as matrices for manuka honey release in wound-care applications. Materials (Basel) 12:10. https://doi.org/10.3390/ma12040559
Nethi SK, Das S, Patra CR, Mukherjee S (2019) Recent advances in inorganic nanomaterials for wound-healing applications Biomaterials. Science 7:2652–2674. https://doi.org/10.1039/C9BM00423H
Oktay B, Kayaman-Apohan N, Erdem-Kuruca S (2014) Fabrication of nanofiber mats from electrospinning of functionalized polymers. IOP Conf Ser 64:012011. https://doi.org/10.1088/1757-899x/64/1/012011
Pandey S, Pandey SK, Parashar V, Mehrotra GK, Pandey AC (2011) Ag/PVA nanocomposites: optical and thermal dimensions. J Mater Chem 21:17154–17159. https://doi.org/10.1039/C1JM13276H
Park JH et al (2012) Poly(vinyl alcohol)/montmorillonite/silver hybrid nanoparticles prepared from aqueous solutions by the electrospraying method. J Compos Mater 47:3367–3378. https://doi.org/10.1177/0021998312465100
Pinto SC et al (2015) Stryphnodendron adstringens: clarifying wound healing in streptozotocin-induced diabetic rats. Planta Med 81:1090–1096. https://doi.org/10.1055/s-0035-1546209
Putu EPK, Ida BADP, Ratna RNR (2018) Honey clinically stimulates granulation and epithelialization in chronic wounds: a report of two cases. Med J Indones 27:5. https://doi.org/10.13181/mji.v27i1.1457
Qi J, Zhang H, Wang Y, Mani MP, Jaganathan SK (2018) Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and Plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering. Int J Nanomed 13:2777–2788. https://doi.org/10.2147/ijn.S151242
Rezvani Z, Venugopal JR, Urbanska AM, Mills DK, Ramakrishna S, Mozafari M (2016) A bird's eye view on the use of electrospun nanofibrous scaffolds for bone tissue engineering: current state-of-the-art, emerging directions and future trends. Nanomedicine 12:2181–2200. https://doi.org/10.1016/j.nano.2016.05.014
Samarghandian S, Farkhondeh T, Samini F (2017) Honey and health: a review of recent clinical research. Pharmacogn Res 9:121–127. https://doi.org/10.4103/0974-8490.204647
Sarhan WA, Azzazy HME, ElSherbiny IM (2016) The effect of increasing honey concentration on the properties of the honey/polyvinyl alcohol/chitosan nanofibers. Mater Sci Eng 67:276–284. https://doi.org/10.1016/j.msec.2016.05.006
Son YJ, Tse JW, Zhou Y, Mao W, Yim EKF, Yoo HS (2019) Biomaterials and controlled release strategy for epithelial wound healing. Biomaterials Science 7:4444–4471. https://doi.org/10.1039/C9BM00456D
Song JJ, Salcido R (2011) Use of honey in wound care: an update. Adv Skin Wound Care 24:40–44. https://doi.org/10.1097/01.Asw.0000392731.34723.06
Stejskalová A, Almquist BD (2017) Using biomaterials to rewire the process of wound repair biomaterials. Science 5:1421–1434. https://doi.org/10.1039/C7BM00295E
Suwantong O, Pankongadisak P, Deachathai S, Supaphol P (2012) Electrospun poly(l-lactic acid) fiber mats containing a crude Garcinia cowa extract for wound dressing applications. J Polym Res 19:9896. https://doi.org/10.1007/s10965-012-98963
Tang C-M, Tian Y-H, Hsu S-H (2015) Poly(vinyl alcohol) nanocomposites reinforced with bamboo charcoal nanoparticles: mineralization behavior and characterization. Materials 8:4895–4911
Tavakoli J, Tang Y (2017) Honey/PVA hybrid wound dressings with controlled release of antibiotics: structural, physico-mechanical and in-vitro biomedical studies. Mater Sci Eng C Mater Biol Appl 77:318–325. https://doi.org/10.1016/j.msec.2017.03.272
Wang S, Hu F, Li J, Zhang S, Shen M, Huang M, Shi X (2018) Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells. Nanomedicine 14:2505–2520. https://doi.org/10.1016/j.nano.2016.12.024
Xiao M, Chery J, Frey MW (2018) Functionalization of electrospun poly(vinyl alcohol) (PVA) nanofiber membranes for selective chemical capture. ACS Appl Nano Mater 1:722–729. https://doi.org/10.1021/acsanm.7b00180
Yao G et al (2019) Self-activated electrical stimulation for effective hair regeneration via a wearable omnidirectional pulse generator. ACS NanoNano 13:12345–12356. https://doi.org/10.1021/acsnano.9b03912
Zanier E, Bordoni B (2015) A multidisciplinary approach to scars: a narrative review. J Multidiscip Healthc 8:359–363. https://doi.org/10.2147/jmdh.S87845
Zargham S, Bazgir S, Tavakoli A, Rashidi AS, Damerchely R (2012) The effect of flow rate on morphology and deposition area of electrospun nylon 6 nanofiber. J Eng Fibers Fabr 7:54. https://doi.org/10.1021/acsnano.8b07038
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
There are no conflicts to declare.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Kanimozhi, S., Kathiresan, G., Kathalingam, A. et al. Organic nanocomposite Band-Aid for chronic wound healing: a novel honey-based nanofibrous scaffold. Appl Nanosci 10, 1639–1652 (2020). https://doi.org/10.1007/s13204-019-01247-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13204-019-01247-3